| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1017 |
Name | CDK2 |
Synonymous | CDKN2|p33(CDK2);cyclin-dependent kinase 2;CDK2;cyclin-dependent kinase 2 |
Definition | cdc2-related protein kinase|cell division protein kinase 2|p33 protein kinase |
Position | 12q13 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
cyclinA(h) + Cdk2(h) <==> cyclinA(h):Cdk2(h) (binding) | cyclinB(h) + Cdk2(h) <==> cyclinB(h):Cdk2(h) (binding) | cyclinE(h) + Cdk2(h) <==> cyclinE(h):Cdk2(h) (binding) | Cdk2(h) + p21Cip1(h) <==> Cdk2(h):p21Cip1(h) (binding) | Cdk2(h) + KAP(h) <==> Cdk2(h):KAP(h) (binding) | Cdk2(h) + ATP --CAK(m)--> Cdk2(h){pT160} + ADP (phosphorylation) | Cdk2(h) + ATP --Wee1(h)--> Cdk2(h){pY15} + ADP (phosphorylation) | Cdk2(h) --> DHFR(ha) (DNA binding). | Cdk2(h) + 14-3-3sigma(m) <==> Cdk2(h):14-3-3sigma(m) (binding) | Cdk2(h) + 14-3-3sigma(h) <==> Cdk2(h):14-3-3sigma(h) (binding) | Cdk2(h) + NF-YA(h) <==> Cdk2(h):NF-YA(h) (binding) | Cdk2(h) + NF-YC-3(h) <==> Cdk2(h):NF-YC-3(h) (binding) | Cdk2(h) + NF-YB(h) <==> Cdk2(h):NF-YB(h) (binding) | Cdk2(h) + axin(m) <==> Cdk2(h):axin(m) (binding) | Cdk2(h) + Pol lambda(h) <==> Cdk2(h):Pol lambda(h) (binding) | Cdk2(h) + POLL(h) <==> Cdk2(h):POLL(h) (binding) | Cdk2(h) + brca1(h) <==> Cdk2(h):brca1(h) (binding) | Cdk2(h) + MGMT(h) <==> Cdk2(h):MGMT(h) (binding) | Cdk2(h) + C/EBPalpha(h) <==> Cdk2(h):C/EBPalpha(h) (binding) | Cdk2(h) + cyclinE1(h) <==> Cdk2(h):cyclinE1(h) (binding) | Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding) | Cdk2(h) + cyclinE(m.s.) <==> Cdk2(h):cyclinE(m.s.) (binding) | Cdk2(h) + 4.1R(h) <==> Cdk2(h):4.1R(h) (binding) | Cdk2(h) + Ubc12(h) <==> Cdk2(h):Ubc12(h) (binding) | VHL(h) + Cdk2(h) <==> VHL(h):Cdk2(h) (binding) | Cdk2(h) + sortilin(h) <==> Cdk2(h):sortilin(h) (binding) | Cdk2(h) + RADIL(h) <==> Cdk2(h):RADIL(h) (binding) | Cdk2(h) + Nedd8(h) <==> Cdk2(h):Nedd8(h) (binding) | Tsc-22(h) + Cdk2(h) <==> Tsc-22(h):Cdk2(h) (binding) | wdr8(h) + Cdk2(h) <==> wdr8(h):Cdk2(h) (binding) | Cdk2(h) + OGT(h) <==> Cdk2(h):OGT(h) (binding) | Caspase-4(h) + Cdk2(h) <==> Caspase-4(h):Cdk2(h) (binding) | Cdk2(h) + DRIP205(h) <==> Cdk2(h):DRIP205(h) (binding) | Cdk2(h) + FBL(h) <==> Cdk2(h):FBL(h) (binding) | PRL3(h) + Cdk2(h) <==> PRL3(h):Cdk2(h) (binding) | Cdk2(h) + ALS2CR7(h) <==> Cdk2(h):ALS2CR7(h) (binding) | Cdk2(h) + p120(h) <==> Cdk2(h):p120(h) (binding) | Cdk2(h) + fam113a(h) <==> Cdk2(h):fam113a(h) (binding) | p107(h) + Cdk2(h) <==> p107(h):Cdk2(h) (binding) | Cdk2(h) + p130(h) <==> p130(h):Cdk2(h) (binding) | ZNF291(h) + Cdk2(h) <==> ZNF291(h):Cdk2(h) (binding) | Cdk2(h) + ATP --> Cdk2(h){pT160} + ADP (phosphorylation) | Cdk2(h) + ATP --> Cdk2(h){pY15} + ADP (phosphorylation) | Cdk2(h){pT160} --PP2Cbeta2(h)--> Cdk2(h) + p (dephosphorylation) | Cdk2(h){pT160} --PP2Calpha1(h)--> Cdk2(h) + p (dephosphorylation) | Cdk2(h){pT160} --PP2A(b)--> Cdk2(h) + p (dephosphorylation) | Cdk2(h){pY15} --Cdc25B(m)--> Cdk2(h) + p (dephosphorylation) | CDK2(h) --> Cdk2(h) (expression). | p75NTR(m.s.) --/ Cdk2(h) (decrease of abundance) | TGFbeta1(h) --/ Cdk2(h) (decrease of abundance) | Histatin-3(m.s.) --> Cdk2(h) (increase of abundance) | NF-YA(h) + ATP --Cdk2(h)--> NF-YA(h){p} + ADP (phosphorylation) | NF-YB(h) + ATP --Cdk2(h)--> NF-YB(h){p} + ADP (phosphorylation) | SK1(h) + ATP --Cdk2(h)--> SK1(h){p} + ADP (phosphorylation) | axin(m) + ATP --Cdk2(h)--> axin(m){pT609}{pS614}{pS621} + ADP (phosphorylation) | Tip60(h) + ATP --Cdk2(h)--> Tip60(h){pS90} + ADP (phosphorylation) | Smad3(h) + 3 ATP --Cdk2(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | Smad3(m.s.) + 3 ATP --Cdk2(h)--> Smad3(m.s.){pT8}{pT178}{pS212} + 3 ADP (phosphorylation) | N-Myc(m.s.) + ATP --Cdk2(h)--> N-Myc(m.s.){p} + ADP (phosphorylation) | brca1(h) + Cdk2(h) <==> brca1(h):Cdk2(h) (binding) | Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding) | Cdk2(h) + p21Cip1(h) <==> Cdk2(h):p21Cip1(h) (binding) | Cdk2(h) + CDP(h) + cyclinA(h) <==> Cdk2(h):CDP(h):cyclinA(h) (binding) | p27Kip1(h) + cyclinE(h) + Cdk2(h) <==> p27Kip1(h):cyclinE(h):Cdk2(h) (binding) | p21Cip1(h) + cyclinE(h) + Cdk2(h) <==> p21Cip1(h):cyclinE(h):Cdk2(h) (binding) | CDK2(h) --> Cdk2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
14 | Phosphothreonine. | Swiss-Prot 53.0 | 15 | Phosphotyrosine (by WEE1). | Swiss-Prot 53.0 | 19 | Phosphotyrosine. | Swiss-Prot 53.0 | 160 | Phosphothreonine (by CAK and CCRK). | Swiss-Prot 53.0 | 14 | Phosphothreonine | 93010995;15302935;15144186 | Phospho.ELM 6.0 | 15 | Phosphotyrosine | 1396589;7743995;15302935;15144186;15659558 | Phospho.ELM 6.0 | 160 | Phosphothreonine (CCRK) | 93010995;15302935;14597612;10085115;8443411 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr12 |
Promoter: 54645326 - 54647326 | IlluminaMethylation27 |
chr12 |
Promoter: 54645326 - 54647326 | IlluminaMethylation27 |
chr12 |
Promoter: 54645326 - 54647326 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 54645326 - 54647326 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 54645326 - 54647326 | GSE27584 |
chr12 |
Promoter: 54645326 - 54647326 | GSE27584 |
chr12 |
Promoter: 54645326 - 54647326 | Agilent_014791_44K |
chr12 |
Promoter: 54645326 - 54647326 | Agilent_014791 |