| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1326 |
Name | MAP3K8 |
Synonym | AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT;mitogen-activated protein kinase kinase kinase 8;MAP3K8;mitogen-activated protein kinase kinase kinase 8 |
Definition | Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2 |
Position | 10p11.23 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 10297 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
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Pathways and Diseases |
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Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Ras signaling in the CD4+ TCR pathway;PID Curated;200088 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | CD28 dependent PI3K/Akt signaling;PID Reactome;500485 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Interleukin-1 signaling;PID Reactome;500490 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Disease | Lung cancer, somatic;OMIM |
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External Links |
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Links to Entrez Gene | 1326 |
Links to all GeneRIF Items | 1326 |
Links to iHOP | 1326 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1326 : length: 1404 atggagtacatgagcactggaagtgacaataaagaagagattgatttattaattaaacat ttaaatgtgtctgatgtaatagacattatggaaaatctttatgcaagtgaagagccagca gtttatgaacccagtctaatgaccatgtgtcaagacagtaatcaaaacgatgagcgttct aagtctctgctgcttagtggccaagaggtaccatggttgtcatcagtcagatatggaact gtggaggatttgcttgcttttgcaaaccatatatccaacactgcaaagcatttttatgga caacgaccacaggaatctggaattttattaaacatggtcatcactccccaaaatggacgt taccaaatagattccgatgttctcctgatcccctggaagctgacttacaggaatattggt tctgattttattcctcggggcgcctttggaaaggtatacttggcacaagatataaagacg aagaaaagaatggcgtgtaaactgatcccagtagatcaatttaagccatctgatgtggaa atccaggcttgcttccggcacgagaacatcgcagagctgtatggcgcagtcctgtggggt gaaactgtccatctctttatggaagcaggcgagggagggtctgttctggagaaactggag agctgtggaccaatgagagaatttgaaattatttgggtgacaaagcatgttctcaaggga cttgattttctacactcaaagaaagtgatccatcatgatattaaacctagcaacattgtt ttcatgtccacaaaagctgttttggtggattttggcctaagtgttcaaatgaccgaagat gtctattttcctaaggacctccgaggaacagagatttacatgagcccagaggtcatcctg tgcaggggccattcaaccaaagcagacatctacagcctgggggccacgctcatccacatg cagacgggcaccccaccctgggtgaagcgctaccctcgctcagcctatccctcctacctg tacataatccacaagcaagcacctccactggaagacattgcagatgactgcagtccaggg atgagagagctgatagaagcttccctggagagaaaccccaatcaccgcccaagagccgca gacctactaaaacatgaggccctgaacccgcccagagaggatcagccacgctgtcagagt ctggactctgccctcttggagcgcaagaggctgctgagtaggaaggagctggaacttcct gagaacattgctgattcttcgtgcacaggaagcaccgaggaatctgagatgctcaagagg caacgctctctctacatcgacctcggcgctctggctggctacttcaatcttgttcgggga ccaccaacgcttgaatatggctga |
Protein Sequence |
>1326 : length: 467 MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG |