| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1326 |
Name | MAP3K8 |
Synonymous | AURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COT;mitogen-activated protein kinase kinase kinase 8;MAP3K8;mitogen-activated protein kinase kinase kinase 8 |
Definition | Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2 |
Position | 10p11.23 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
Cot(h) + NIK(h) <==> Cot(h):NIK(h) (binding) | Cot(h) --> IKK-alpha(m) (activation) | TRAF2(m) + Cot(h) <==> TRAF2(m):Cot(h) (binding) | Cot(h) + NF-kappaB1(h) <==> Cot(h):NF-kappaB1(h) (binding) | NF-kappaB1-p50(h):NF-kappaB1(h):RelA-p65(h) + Cot(h) <==> NF-kappaB1-p50(h):NF-kappaB1(h):RelA-p65(h):Cot(h) (binding) | NF-kappaB1-p50(h):NF-kappaB1(h):c-Rel(h) + Cot(h) <==> NF-kappaB1-p50(h):NF-kappaB1(h):c-Rel(h):Cot(h) (binding) | AKT(b) + Cot(h) <==> AKT(b):Cot(h) (binding) | Cot(h) + ATP --> Cot(h){p} + ADP (phosphorylation) | NF-kappaB1-isoform2(h) + Cot(h) <==> NF-kappaB1-isoform2(h):Cot(h) (binding) | MAP3K8(h) --> Cot(h) (expression). | MKK6(h) + ATP --Cot(h)--> MKK6(h){p} + ADP (phosphorylation) | MKK4(m) + ATP --Cot(h)--> MKK4(m){p} + ADP (phosphorylation) | Cot-58kDa(h) + ATP --> Cot-58kDa(h){pS62} + ADP (phosphorylation) | Cot-58kDa(h) + 2 ATP --> Cot-58kDa(h){pS62}{pT290} + 2 ADP (phosphorylation) | MAP3K8(h) --> Cot-58kDa(h) (expression). | MAP3K8(h) --> Cot-52kDa(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
413 | Phosphoserine | 12138205 | Phospho.ELM 6.0 | 290 | Phosphothreonine | 15466476 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr10 |
Promoter: 30761372 - 30763372 | Agilent_014791 |
chr10 |
Promoter: 30761372 - 30763372 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 30761372 - 30763372 | GSE27584 |
chr10 |
Promoter: 30761372 - 30763372 | Agilent_014791_44K |