| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1969 |
Name | EPHA2 |
Synonym | ARCC2|CTPA|CTPP1|CTRCT6|ECK;EPH receptor A2;EPHA2;EPH receptor A2 |
Definition | ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK |
Position | 1p36 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 141 |
TUSON P-value | 0.000121516 |
|
Pathways and Diseases |
|
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | EphrinA-EPHA pathway;PID Curated;200040 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Arf6 signaling events;PID Curated;200060 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Disease | Drug abuse;FunDO |
Disease | Cataract, posterior polar, 1;OMIM |
Disease | VISION;GAD |
Disease | Cancer;FunDO |
Disease | Cataract;GAD |
|
External Links |
|
Links to Entrez Gene | 1969 |
Links to all GeneRIF Items | 1969 |
Links to iHOP | 1969 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>1969 : length: 2931 atggagctccaggcagcccgcgcctgcttcgccctgctgtggggctgtgcgctggccgcg gccgcggcggcgcagggcaaggaagtggtactgctggactttgctgcagctggaggggag ctcggctggctcacacacccgtatggcaaagggtgggacctgatgcagaacatcatgaat gacatgccgatctacatgtactccgtgtgcaacgtgatgtctggcgaccaggacaactgg ctccgcaccaactgggtgtaccgaggagaggctgagcgtatcttcattgagctcaagttt actgtacgtgactgcaacagcttccctggtggcgccagctcctgcaaggagactttcaac ctctactatgccgagtcggacctggactacggcaccaacttccagaagcgcctgttcacc aagattgacaccattgcgcccgatgagatcaccgtcagcagcgacttcgaggcacgccac gtgaagctgaacgtggaggagcgctccgtggggccgctcacccgcaaaggcttctacctg gccttccaggatatcggtgcctgtgtggcgctgctctccgtccgtgtctactacaagaag tgccccgagctgctgcagggcctggcccacttccctgagaccatcgccggctctgatgca ccttccctggccactgtggccggcacctgtgtggaccatgccgtggtgccaccggggggt gaagagccccgtatgcactgtgcagtggatggcgagtggctggtgcccattgggcagtgc ctgtgccaggcaggctacgagaaggtggaggatgcctgccaggcctgctcgcctggattt tttaagtttgaggcatctgagagcccctgcttggagtgccctgagcacacgctgccatcc cctgagggtgccacctcctgcgagtgtgaggaaggcttcttccgggcacctcaggaccca gcgtcgatgccttgcacacgacccccctccgccccacactacctcacagccgtgggcatg ggtgccaaggtggagctgcgctggacgccccctcaggacagcgggggccgcgaggacatt gtctacagcgtcacctgcgaacagtgctggcccgagtctggggaatgcgggccgtgtgag gccagtgtgcgctactcggagcctcctcacggactgacccgcaccagtgtgacagtgagc gacctggagccccacatgaactacaccttcaccgtggaggcccgcaatggcgtctcaggc ctggtaaccagccgcagcttccgtactgccagtgtcagcatcaaccagacagagcccccc aaggtgaggctggagggccgcagcaccacctcgcttagcgtctcctggagcatccccccg ccgcagcagagccgagtgtggaagtacgaggtcacttaccgcaagaagggagactccaac agctacaatgtgcgccgcaccgagggtttctccgtgaccctggacgacctggccccagac accacctacctggtccaggtgcaggcactgacgcaggagggccagggggccggcagcaag gtgcacgaattccagacgctgtccccggagggatctggcaacttggcggtgattggcggc gtggctgtcggtgtggtcctgcttctggtgctggcaggagttggcttctttatccaccgc aggaggaagaaccagcgtgcccgccagtccccggaggacgtttacttctccaagtcagaa caactgaagcccctgaagacatacgtggacccccacacatatgaggaccccaaccaggct gtgttgaagttcactaccgagatccatccatcctgtgtcactcggcagaaggtgatcgga gcaggagagtttggggaggtgtacaagggcatgctgaagacatcctcggggaagaaggag gtgccggtggccatcaagacgctgaaagccggctacacagagaagcagcgagtggacttc ctcggcgaggccggcatcatgggccagttcagccaccacaacatcatccgcctagagggc gtcatctccaaatacaagcccatgatgatcatcactgagtacatggagaatggggccctg gacaagttccttcgggagaaggatggcgagttcagcgtgctgcagctggtgggcatgctg cggggcatcgcagctggcatgaagtacctggccaacatgaactatgtgcaccgtgacctg gctgcccgcaacatcctcgtcaacagcaacctggtctgcaaggtgtctgactttggcctg tcccgcgtgctggaggacgaccccgaggccacctacaccaccagtggcggcaagatcccc atccgctggaccgccccggaggccatttcctaccggaagttcacctctgccagcgacgtg tggagctttggcattgtcatgtgggaggtgatgacctatggcgagcggccctactgggag ttgtccaaccacgaggtgatgaaagccatcaatgatggcttccggctccccacacccatg gactgcccctccgccatctaccagctcatgatgcagtgctggcagcaggagcgtgcccgc cgccccaagttcgctgacatcgtcagcatcctggacaagctcattcgtgcccctgactcc ctcaagaccctggctgactttgacccccgcgtgtctatccggctccccagcacgagcggc tcggagggggtgcccttccgcacggtgtccgagtggctggagtccatcaagatgcagcag tatacggagcacttcatggcggccggctacactgccatcgagaaggtggtgcagatgacc aacgacgacatcaagaggattggggtgcggctgcccggccaccagaagcgcatcgcctac agcctgctgggactcaaggaccaggtgaacactgtggggatccccatctga |
Protein Sequence |
>1969 : length: 976 MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMN DMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFN LYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGG EEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPS PEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDI VYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSN SYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGG VAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQA VLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF LGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGML RGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIP IRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSG SEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAY SLLGLKDQVNTVGIPI |