| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2034 |
Name | EPAS1 |
Synonym | ECYT4|HIF2A|HLF|MOP2|PASD2|bHLHe73;endothelial PAS domain protein 1;EPAS1;endothelial PAS domain protein 1 |
Definition | EPAS-1|HIF-1-alpha-like factor|HIF-1alpha-like factor|HIF-2-alpha|HIF2-alpha|PAS domain-containing protein 2|basic-helix-loop-helix-PAS protein MOP2|class E basic helix-loop-helix protein 73|endothelial PAS domain-containing protein 1|hypoxia-inducible fa |
Position | 2p21-p16 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6559 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | elite endurance;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Cancer;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Congenital polycythemia;KEGG DISEASE;H00236 |
Disease | Erythrocytosis, familial, 4;OMIM |
Disease | NORMALVARIATION;GAD |
|
External Links |
|
Links to Entrez Gene | 2034 |
Links to all GeneRIF Items | 2034 |
Links to iHOP | 2034 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2034 : length: 2613 atgacagctgacaaggagaagaaaaggagtagctcggagaggaggaaggagaagtcccgg gatgctgcgcggtgccggcggagcaaggagacggaggtgttctatgagctggcccatgag ctgcctctgccccacagtgtgagctcccatctggacaaggcctccatcatgcgactggca atcagcttcctgcgaacacacaagctcctctcctcagtttgctctgaaaacgagtccgaa gccgaagctgaccagcagatggacaacttgtacctgaaagccttggagggtttcattgcc gtggtgacccaagatggcgacatgatctttctgtcagaaaacatcagcaagttcatggga cttacacaggtggagctaacaggacatagtatctttgacttcactcatccctgcgaccat gaggagattcgtgagaacctgagtctcaaaaatggctctggttttgggaaaaaaagcaaa gacatgtccacagagcgggacttcttcatgaggatgaagtgcacggtcaccaacagaggc cgtactgtcaacctcaagtcagccacctggaaggtcttgcactgcacgggccaggtgaaa gtctacaacaactgccctcctcacaatagtctgtgtggctacaaggagcccctgctgtcc tgcctcatcatcatgtgtgaaccaatccagcacccatcccacatggacatccccctggat agcaagaccttcctgagccgccacagcatggacatgaagttcacctactgtgatgacaga atcacagaactgattggttaccaccctgaggagctgcttggccgctcagcctatgaattc taccatgcgctagactccgagaacatgaccaagagtcaccagaacttgtgcaccaagggt caggtagtaagtggccagtaccggatgctcgcaaagcatgggggctacgtgtggctggag acccaggggacggtcatctacaaccctcgcaacctgcagccccagtgcatcatgtgtgtc aactacgtcctgagtgagattgagaagaatgacgtggtgttctccatggaccagactgaa tccctgttcaagccccacctgatggccatgaacagcatctttgatagcagtggcaagggg gctgtgtctgagaagagtaacttcctattcaccaagctaaaggaggagcccgaggagctg gcccagctggctcccaccccaggagacgccatcatctctctggatttcgggaatcagaac ttcgaggagtcctcagcctatggcaaggccatcctgcccccgagccagccatgggccacg gagttgaggagccacagcacccagagcgaggctgggagcctgcctgccttcaccgtgccc caggcagctgccccgggcagcaccacccccagtgccaccagcagcagcagcagctgctcc acgcccaatagccctgaagactattacacatctttggataacgacctgaagattgaagtg attgagaagctcttcgccatggacacagaggccaaggaccaatgcagtacccagacggat ttcaatgagctggacttggagacactggcaccctatatccccatggacggggaagacttc cagctaagccccatctgccccgaggagcggctcttggcggagaacccacagtccaccccc cagcactgcttcagtgccatgacaaacatcttccagccactggcccctgtagccccgcac agtcccttcctcctggacaagtttcagcagcagctggagagcaagaagacagagcccgag caccggcccatgtcctccatcttctttgatgccggaagcaaagcatccctgccaccgtgc tgtggccaggccagcacccctctctcttccatggggggcagatccaatacccagtggccc ccagatccaccattacattttgggcccacaaagtgggccgtcggggatcagcgcacagag ttcttgggagcagcgccgttggggccccctgtctctccaccccatgtctccaccttcaag acaaggtctgcaaagggttttggggctcgaggcccagacgtgctgagtccggccatggta gccctctccaacaagctgaagctgaagcgacagctggagtatgaagagcaagccttccag gacctgagcgggggggacccacctggtggcagcacctcacatttgatgtggaaacggatg aagaacctcaggggtgggagctgccctttgatgccggacaagccactgagcgcaaatgta cccaatgataagttcacccaaaaccccatgaggggcctgggccatcccctgagacatctg ccgctgccacagcctccatctgccatcagtcccggggagaacagcaagagcaggttcccc ccacagtgctacgccacccagtaccaggactacagcctgtcgtcagcccacaaggtgtca ggcatggcaagccggctgctcgggccctcatttgagtcctacctgctgcccgaactgacc agatatgactgtgaggtgaacgtgcccgtgctgggaagctccacgctcctgcaaggaggg gacctcctcagagccctggaccaggccacctga |
Protein Sequence |
>2034 : length: 870 MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDF QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ DLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHL PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT RYDCEVNVPVLGSSTLLQGGDLLRALDQAT |