Entrez Gene

Basic Information
Gene ID	2034
Name	EPAS1
Synonymous	ECYT4\|HIF2A\|HLF\|MOP2\|PASD2\|bHLHe73;endothelial PAS domain protein 1;EPAS1;endothelial PAS domain protein 1
Definition	EPAS-1\|HIF-1-alpha-like factor\|HIF-1alpha-like factor\|HIF-2-alpha\|HIF2-alpha\|PAS domain-containing protein 2\|basic-helix-loop-helix-PAS protein MOP2\|class E basic helix-loop-helix protein 73\|endothelial PAS domain-containing protein 1\|hypoxia-inducible fa
Position	2p21-p16
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
HIF2A(h) + arnt(h) <==> HIF2A(h):arnt(h) (binding).
HIF2A(h) + CBP(v.s.) <==> HIF2A(h):CBP(v.s.) (binding)
HIF2A(h) + VHL(h) <==> HIF2A(h):VHL(h) (binding)
HIF2A(h) + VHL(h):elongin B(h):elongin C(h) <==> HIF2A(h):VHL(h):elongin B(h):elongin C(h) (binding)
HIF2A(h) + n ubiquitin(h) --VHL(h)--> HIF2A(h){ub(n)} (ubiquitination)
bbs1(h) + HIF2A(h) <==> bbs1(h):HIF2A(h) (binding)
bbs2(h) + HIF2A(h) <==> bbs2(h):HIF2A(h) (binding)
bbs4(h) + HIF2A(h) <==> bbs4(h):HIF2A(h) (binding)
HIF2A(h) --> CXCL12(h) (transactivation)
EPAS1(h) --> HIF2A(h) (expression).
ATF-3(h) --> HIF2A(h) (activation; increase of abundance)
JAB1(h) --> HIF2A(h) (increase of abundance)
COPS2(h) --> HIF2A(h) (increase of abundance)
HIF2A(h) --> MIRN210(h) (DNA binding).
EPAS1(h) --> HIF2A(h) (expression).

Location (AA)	PTM type	Database
Post Transcriptional Modification [Top]
405	4-hydroxyproline (By similarity).	Swiss-Prot 53.0
531	4-hydroxyproline (By similarity).	Swiss-Prot 53.0
840	Phosphothreonine (By similarity).	Swiss-Prot 53.0
847	3-hydroxyasparagine (By similarity).	Swiss-Prot 53.0