| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2048 |
Name | EPHB2 |
Synonym | CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5;EPH receptor B2;EPHB2;EPH receptor B2 |
Definition | EPH-like kinase 5|developmentally-regulated Eph-related tyrosine kinase|elk-related tyrosine kinase|eph tyrosine kinase 3|ephrin type-B receptor 2|protein-tyrosine kinase HEK5|renal carcinoma antigen NY-REN-47|tyrosine-protein kinase TYRO5|tyrosine-protei |
Position | 1p36.1-p35 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6580 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | EphrinB-EPHB pathway;PID Curated;200141 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | L1CAM interactions;PID Reactome;500097 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Disease | CANCER;GAD |
Disease | Prostate cancer, progression and metastasis of;OMIM |
Disease | prostate cancer;GAD |
Disease | Congenital abnormality;FunDO |
Disease | Cancer;FunDO |
Disease | colorectal cancer hyperplastic polyposis;GAD |
|
External Links |
|
Links to Entrez Gene | 2048 |
Links to all GeneRIF Items | 2048 |
Links to iHOP | 2048 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2048 : length: 2964 atggctctgcggaggctgggggccgcgctgctgctgctgccgctgctcgccgccgtggaa gaaacgctaatggactccactacagcgactgctgagctgggctggatggtgcatcctcca tcagggtgggaagaggtgagtggctacgatgagaacatgaacacgatccgcacgtaccag gtgtgcaacgtgtttgagtcaagccagaacaactggctacggaccaagtttatccggcgc cgtggcgcccaccgcatccacgtggagatgaagttttcggtgcgtgactgcagcagcatc cccagcgtgcctggctcctgcaaggagaccttcaacctctattactatgaggctgacttt gactcggccaccaagaccttccccaactggatggagaatccatgggtgaaggtggatacc attgcagccgacgagagcttctcccaggtggacctgggtggccgcgtcatgaaaatcaac accgaggtgcggagcttcggacctgtgtcccgcagcggcttctacctggccttccaggac tatggcggctgcatgtccctcatcgccgtgcgtgtcttctaccgcaagtgcccccgcatc atccagaatggcgccatcttccaggaaaccctgtcgggggctgagagcacatcgctggtg gctgcccggggcagctgcatcgccaatgcggaagaggtggatgtacccatcaagctctac tgtaacggggacggcgagtggctggtgcccatcgggcgctgcatgtgcaaagcaggcttc gaggccgttgagaatggcaccgtctgccgaggttgtccatctgggactttcaaggccaac caaggggatgaggcctgtacccactgtcccatcaacagccggaccacttctgaaggggcc accaactgtgtctgccgcaatggctactacagagcagacctggaccccctggacatgccc tgcacaaccatcccctccgcgccccaggctgtgatttccagtgtcaatgagacctccctc atgctggagtggacccctccccgcgactccggaggccgagaggacctcgtctacaacatc atctgcaagagctgtggctcgggccggggtgcctgcacccgctgcggggacaatgtacag tacgcaccacgccagctaggcctgaccgagccacgcatttacatcagtgacctgctggcc cacacccagtacaccttcgagatccaggctgtgaacggcgttactgaccagagccccttc tcgcctcagttcgcctctgtgaacatcaccaccaaccaggcagctccatcggcagtgtcc atcatgcatcaggtgagccgcaccgtggacagcattaccctgtcgtggtcccagccggac cagcccaatggcgtgatcctggactatgagctgcagtactatgagaaggagctcagtgag tacaacgccacagccataaaaagccccaccaacacggtcaccgtgcagggcctcaaagcc ggcgccatctatgtcttccaggtgcgggcacgcaccgtggcaggctacgggcgctacagc ggcaagatgtacttccagaccatgacagaagccgagtaccagacaagcatccaggagaag ttgccactcatcatcggctcctcggccgctggcctggtcttcctcattgctgtggttgtc atcgccatcgtgtgtaacagaagacgggggtttgagcgtgctgactcggagtacacggac aagctgcaacactacaccagtggccacatgaccccaggcatgaagatctacatcgatcct ttcacctacgaggaccccaacgaggcagtgcgggagtttgccaaggaaattgacatctcc tgtgtcaaaattgagcaggtgatcggagcaggggagtttggcgaggtctgcagtggccac ctgaagctgccaggcaagagagagatctttgtggccatcaagacgctcaagtcgggctac acggagaagcagcgccgggacttcctgagcgaagcctccatcatgggccagttcgaccat cccaacgtcatccacctggagggtgtcgtgaccaagagcacacctgtgatgatcatcacc gagttcatggagaatggctccctggactcctttctccggcaaaacgatgggcagttcaca gtcatccagctggtgggcatgcttcggggcatcgcagctggcatgaagtacctggcagac atgaactatgttcaccgtgacctggctgcccgcaacatcctcgtcaacagcaacctggtc tgcaaggtgtcggactttgggctctcacgctttctagaggacgatacctcagaccccacc tacaccagtgccctgggcggaaagatccccatccgctggacagccccggaagccatccag taccggaagttcacctcggccagtgatgtgtggagctacggcattgtcatgtgggaggtg atgtcctatggggagcggccctactgggacatgaccaaccaggatgtaatcaatgccatt gagcaggactatcggctgccaccgcccatggactgcccgagcgccctgcaccaactcatg ctggactgttggcagaaggaccgcaaccaccggcccaagttcggccaaattgtcaacacg ctagacaagatgatccgcaatcccaacagcctcaaagccatggcgcccctctcctctggc atcaacctgccgctgctggaccgcacgatccccgactacaccagctttaacacggtggac gagtggctggaggccatcaagatggggcagtacaaggagagcttcgccaatgccggcttc acctcctttgacgtcgtgtctcagatgatgatggaggacattctccgggttggggtcact ttggctggccaccagaaaaaaatcctgaacagtatccaggtgatgcgggcgcagatgaac cagattcagtctgtggaggtttga |
Protein Sequence |
>2048 : length: 987 MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK LPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDP FTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY TEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSG INLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVT LAGHQKKILNSIQVMRAQMNQIQSVEV |