Entrez Gene

Basic Information
Gene ID	2048
Name	EPHB2
Synonymous	EPH receptor B2;EPHB2;EPH receptor B2
Definition	EPH-like kinase 5\|developmentally-regulated Eph-related tyrosine kinase\|elk-related tyrosine kinase\|eph tyrosine kinase 3\|ephrin type-B receptor 2\|protein-tyrosine kinase HEK5\|renal carcinoma antigen NY-REN-47\|tyrosine-protein kinase TYRO5\|tyrosine-protei
Position	1p36.1-p35
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.03.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1882G>A; p.G628R; 1:22906103-22906103	pancreas	carcinoma	Substitution - Missense
c.1036C>A; p.P346T; 1:22864945-22864945	liver	carcinoma	Substitution - Missense
c.2372G>A; p.R791H; 1:22909041-22909041	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2107G>T; p.E703*; 1:22906928-22906928	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1036C>A; p.P346T; 1:22864945-22864945	liver	carcinoma	Substitution - Missense
c.2365C>T; p.P789S; 1:22909034-22909034	skin	malignant_melanoma	Substitution - Missense
c.1647C>T; p.A549A; 1:22895527-22895527	skin	malignant_melanoma	Substitution - coding silent
c.1432C>T; p.L478F; 1:22892887-22892887	liver	carcinoma	Substitution - Missense
c.1432C>T; p.L478F; 1:22892887-22892887	liver	carcinoma	Substitution - Missense
c.1889-1G>C; p.?; 1:22906709-22906709	urinary_tract; bladder	carcinoma	Unknown
c.2409C>T; p.F803F; 1:22909078-22909078	skin	malignant_melanoma	Substitution - coding silent
c.1340G>A; p.R447H; 1:22882395-22882395	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2802C>T; p.F934F; 1:22912549-22912549	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1725G>A; p.S575S; 1:22896438-22896438	skin	malignant_melanoma	Substitution - coding silent
c.69A>G; p.L23L; 1:22781428-22781428	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2346T>G; p.S782R; 1:22908162-22908162	skin	malignant_melanoma	Substitution - Missense
c.366G>A; p.S122S; 1:22784631-22784631	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.426A>C; p.A142A; 1:22784691-22784691	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2628T>G; p.I876M; 1:22910507-22910507	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.824G>A; p.G275E; 1:22863049-22863049	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2200A>G; p.M734V; 1:22908016-22908016	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.E246K; 1:22785001-22785001	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.631C>T; p.L211L; 1:22784896-22784896	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.987G>A; p.Q329Q; 1:22864896-22864896	skin	malignant_melanoma	Substitution - coding silent
c.1290C>T; p.T430T; 1:22865199-22865199	skin	malignant_melanoma	Substitution - coding silent
c.1049C>T; p.S350F; 1:22864958-22864958	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1454C>T; p.A485V; 1:22892909-22892909	skin	malignant_melanoma	Substitution - Missense
c.1407T>A; p.Y469*; 1:22882462-22882462	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.242G>A; p.R81H; 1:22784507-22784507	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.914G>A; p.C305Y; 1:22863139-22863139	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2474G>A; p.R825Q; 1:22909143-22909143	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2474G>A; p.R825Q; 1:22909143-22909143	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1980G>A; p.T660T; 1:22906801-22906801	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.325G>A; p.E109K; 1:22784590-22784590	skin; arm	malignant_melanoma	Substitution - Missense
c.1980G>A; p.T660T; 1:22906801-22906801	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1638C>A; p.G546G; 1:22895518-22895518	thyroid	other; neoplasm	Substitution - coding silent
c.1733C>T; p.T578M; 1:22896446-22896446	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.170G>A; p.R57H; 1:22784435-22784435	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3097C>T; p.R1033W; 1:22913799-22913799	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2660C>T; p.P887L; 1:22910539-22910539	skin; shoulder	malignant_melanoma	Substitution - Missense
c.1043G>A; p.R348H; 1:22864952-22864952	pancreas	carcinoma	Substitution - Missense
c.2560G>A; p.A854T; 1:22910439-22910439	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1043G>A; p.R348H; 1:22864952-22864952	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1722C>T; p.D574D; 1:22896435-22896435	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1734G>A; p.T578T; 1:22896447-22896447	skin	malignant_melanoma	Substitution - coding silent
c.1722C>T; p.D574D; 1:22896435-22896435	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2031C>T; p.F677F; 1:22906852-22906852	skin	malignant_melanoma	Substitution - coding silent
c.2513C>G; p.A838G; 1:22910392-22910392	urinary_tract; bladder	carcinoma	Substitution - Missense
c.917G>A; p.R306H; 1:22863142-22863142	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.568G>A; p.V190M; 1:22784833-22784833	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.591C>T; p.C197C; 1:22784856-22784856	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1796C>T; p.P599L; 1:22906017-22906017	skin	malignant_melanoma	Substitution - Missense
c.1796C>T; p.P599L; 1:22906017-22906017	skin	malignant_melanoma	Substitution - Missense
c.2446A>G; p.M816V; 1:22909115-22909115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2832C>T; p.V944V; 1:22912579-22912579	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.2832C>T; p.V944V; 1:22912579-22912579	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.2832C>T; p.V944V; 1:22912579-22912579	skin	malignant_melanoma	Substitution - coding silent
c.318C>A; p.S106S; 1:22784583-22784583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.232A>T; p.I78F; 1:22784497-22784497	skin	malignant_melanoma	Substitution - Missense
c.978C>T; p.S326S; 1:22864887-22864887	skin	malignant_melanoma	Substitution - coding silent
c.746T>G; p.V249G; 1:22785011-22785011	thyroid	other; neoplasm	Substitution - Missense
c.978C>T; p.S326S; 1:22864887-22864887	skin	malignant_melanoma	Substitution - coding silent
c.1994G>A; p.R665Q; 1:22906815-22906815	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.978C>T; p.S326S; 1:22864887-22864887	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.746T>G; p.V249G; 1:22785011-22785011	skin; ear	malignant_melanoma	Substitution - Missense
c.2058G>A; p.E686E; 1:22906879-22906879	skin	malignant_melanoma	Substitution - coding silent
c.1371C>T; p.S457S; 1:22882426-22882426	skin	malignant_melanoma	Substitution - coding silent
c.235C>T; p.R79W; 1:22784500-22784500	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.682G>A; p.A228T; 1:22784947-22784947	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2804C>G; p.A935G; 1:22912551-22912551	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.235C>T; p.R79W; 1:22784500-22784500	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2289G>A; p.S763S; 1:22908105-22908105	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2289G>A; p.S763S; 1:22908105-22908105	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2289G>A; p.S763S; 1:22908105-22908105	skin	malignant_melanoma	Substitution - coding silent
c.2289G>A; p.S763S; 1:22908105-22908105	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.980C>T; p.A327V; 1:22864889-22864889	prostate	carcinoma	Substitution - Missense
c.238C>T; p.R80C; 1:22784503-22784503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2864G>T; p.R955L; 1:22913473-22913473	skin	malignant_melanoma	Substitution - Missense
c.3092delG; p.R1033fs*>23; 1:22913794-22913794	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2789A>G; p.Y930C; 1:22912536-22912536	meninges	meningioma	Substitution - Missense
c.2378C>A; p.T793K; 1:22909047-22909047	thyroid	other; neoplasm	Substitution - Missense
c.2164C>T; p.Q722*; 1:22907980-22907980	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1086C>T; p.C362C; 1:22864995-22864995	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2517T>G; p.I839M; 1:22910396-22910396	breast	carcinoma	Substitution - Missense
c.654G>A; p.S218S; 1:22784919-22784919	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1027G>A; p.E343K; 1:22864936-22864936	skin	malignant_melanoma	Substitution - Missense
c.1772C>T; p.P591L; 1:22905993-22905993	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2107G>A; p.E703K; 1:22906928-22906928	skin	malignant_melanoma	Substitution - Missense
c.2958C>A; p.G986G; 1:22913660-22913660	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2107G>A; p.E703K; 1:22906928-22906928	skin	malignant_melanoma	Substitution - Missense
c.1301C>T; p.A434V; 1:22865210-22865210	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1792G>A; p.D598N; 1:22906013-22906013	skin	malignant_melanoma	Substitution - Missense
c.653C>T; p.S218L; 1:22784918-22784918	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.164C>T; p.T55M; 1:22784429-22784429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3127G>A; p.D1043N; 1:22913829-22913829	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.164C>T; p.T55M; 1:22784429-22784429	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2060G>A; p.G687D; 1:22906881-22906881	skin	malignant_melanoma	Substitution - Missense
c.1991G>T; p.R664L; 1:22906812-22906812	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2670delC; p.A892fs*57; 1:22910549-22910549	pancreas	carcinoma; adenocarcinoma	Deletion - Frameshift
c.118C>T; p.P40S; 1:22781477-22781477	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.853G>A; p.A285T; 1:22863078-22863078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.848A>G; p.D283G; 1:22863073-22863073	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.278C>T; p.S93L; 1:22784543-22784543	skin	malignant_melanoma	Substitution - Missense
c.3051A>G; p.G1017G; 1:22913753-22913753	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2830G>A; p.V944I; 1:22912577-22912577	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.394G>A; p.E132K; 1:22784659-22784659	skin	malignant_melanoma	Substitution - Missense
c.2414C>T; p.S805L; 1:22909083-22909083	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1306C>T; p.P436S; 1:22882361-22882361	skin; scalp	malignant_melanoma	Substitution - Missense
c.1168G>T; p.E390*; 1:22865077-22865077	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1068C>T; p.L356L; 1:22864977-22864977	breast	carcinoma	Substitution - coding silent
c.294C>A; p.S98R; 1:22784559-22784559	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1257C>T; p.P419P; 1:22865166-22865166	liver	carcinoma	Substitution - coding silent
c.780C>T; p.F260F; 1:22785045-22785045	skin	malignant_melanoma	Substitution - coding silent
c.507G>A; p.V169V; 1:22784772-22784772	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1257C>T; p.P419P; 1:22865166-22865166	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2044G>A; p.V682I; 1:22906865-22906865	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1971G>T; p.S657S; 1:22906792-22906792	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1276T>C; p.S426P; 1:22865185-22865185	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.189C>T; p.N63N; 1:22784454-22784454	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2233C>T; p.R745C; 1:22908049-22908049	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1561G>A; p.G521S; 1:22893016-22893016	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2373C>A; p.R791R; 1:22909042-22909042	pancreas	carcinoma	Substitution - coding silent
c.2191G>A; p.A731T; 1:22908007-22908007	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3010C>T; p.P1004S; 1:22913712-22913712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.636G>A; p.S212S; 1:22784901-22784901	pancreas	NS	Substitution - coding silent
c.636G>A; p.S212S; 1:22784901-22784901	pancreas	carcinoma	Substitution - coding silent
c.793A>G; p.N265D; 1:22785058-22785058	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1177delA; p.I393fs*19; 1:22865086-22865086	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1246G>T; p.D416Y; 1:22865155-22865155	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.115C>T; p.P39S; 1:22781474-22781474	skin	malignant_melanoma	Substitution - Missense
c.1575C>T; p.F525F; 1:22893030-22893030	skin	malignant_melanoma	Substitution - coding silent
c.2531G>A; p.R844Q; 1:22910410-22910410	skin	malignant_melanoma	Substitution - Missense
c.753C>T; p.I251I; 1:22785018-22785018	breast	carcinoma	Substitution - coding silent
c.1126G>A; p.G376R; 1:22865035-22865035	skin	malignant_melanoma	Substitution - Missense
c.2595G>A; p.K865K; 1:22910474-22910474	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.181G>C; p.V61L; 1:22784446-22784446	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1052G>A; p.G351E; 1:22864961-22864961	skin	malignant_melanoma	Substitution - Missense
c.2353-1G>T; p.?; 1:22909021-22909021	skin	malignant_melanoma	Unknown
c.488T>C; p.V163A; 1:22784753-22784753	skin	malignant_melanoma	Substitution - Missense
c.2881G>A; p.A961T; 1:22913490-22913490	skin	malignant_melanoma	Substitution - Missense
c.491G>A; p.R164Q; 1:22784756-22784756	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.491G>A; p.R164Q; 1:22784756-22784756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2619C>T; p.F873F; 1:22910498-22910498	skin	malignant_melanoma	Substitution - coding silent
c.517G>A; p.G173S; 1:22784782-22784782	liver	carcinoma	Substitution - Missense
c.1927C>A; p.P643T; 1:22906748-22906748	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.517G>A; p.G173S; 1:22784782-22784782	liver	carcinoma	Substitution - Missense
c.984C>A; p.P328P; 1:22864893-22864893	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1881C>T; p.I627I; 1:22906102-22906102	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1535C>T; p.T512I; 1:22892990-22892990	skin; arm	malignant_melanoma	Substitution - Missense
c.1627C>T; p.L543F; 1:22895507-22895507	breast	carcinoma	Substitution - Missense
c.1420T>C; p.Y474H; 1:22882475-22882475	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2463C>G; p.S821S; 1:22909132-22909132	kidney	other; neoplasm	Substitution - coding silent
c.1390G>A; p.G464S; 1:22882445-22882445	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.A177A; 1:22784796-22784796	breast	carcinoma	Substitution - coding silent
c.1552C>T; p.R518C; 1:22893007-22893007	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1552C>T; p.R518C; 1:22893007-22893007	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.2675C>A; p.A892D; 1:22910554-22910554	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2562C>T; p.A854A; 1:22910441-22910441	skin	malignant_melanoma	Substitution - coding silent
c.220C>T; p.R74W; 1:22784485-22784485	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.949C>A; p.L317M; 1:22863174-22863174	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.999C>T; p.S333S; 1:22864908-22864908	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1069G>A; p.V357I; 1:22864978-22864978	breast	carcinoma	Substitution - Missense
c.1069G>A; p.V357I; 1:22864978-22864978	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.952G>A; p.D318N; 1:22863177-22863177	skin; shoulder	malignant_melanoma	Substitution - Missense
c.1724C>T; p.S575L; 1:22896437-22896437	oesophagus	carcinoma	Substitution - Missense
c.1402G>T; p.D468Y; 1:22882457-22882457	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1491C>A; p.G497G; 1:22892946-22892946	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3150C>T; p.D1050D; 1:22913852-22913852	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1765+2T>C; p.?; 1:22896480-22896480	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.509C>T; p.S170F; 1:22784774-22784774	skin	malignant_melanoma	Substitution - Missense
c.509C>T; p.S170F; 1:22784774-22784774	skin	malignant_melanoma	Substitution - Missense
c.207G>A; p.Q69Q; 1:22784472-22784472	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.306C>T; p.S102S; 1:22784571-22784571	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2234G>C; p.R745P; 1:22908050-22908050	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1122C>T; p.R374R; 1:22865031-22865031	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2007C>T; p.S669S; 1:22906828-22906828	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2007C>T; p.S669S; 1:22906828-22906828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2007C>T; p.S669S; 1:22906828-22906828	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2007C>T; p.S669S; 1:22906828-22906828	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.466G>A; p.V156I; 1:22784731-22784731	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2653C>T; p.R885C; 1:22910532-22910532	skin	malignant_melanoma	Substitution - Missense
c.2599C>T; p.R867C; 1:22910478-22910478	skin	malignant_melanoma	Substitution - Missense
c.2298G>A; p.G766G; 1:22908114-22908114	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2581G>A; p.D861N; 1:22910460-22910460	skin	malignant_melanoma	Substitution - Missense
c.2652C>T; p.I884I; 1:22910531-22910531	skin	malignant_melanoma	Substitution - coding silent
c.466G>A; p.V156I; 1:22784731-22784731	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.450G>A; p.V150V; 1:22784715-22784715	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.329C>A; p.T110N; 1:22784594-22784594	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2238C>T; p.D746D; 1:22908054-22908054	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1365G>A; p.S455S; 1:22882420-22882420	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1702C>T; p.R568W; 1:22896415-22896415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1830G>A; p.R610R; 1:22906051-22906051	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1702C>T; p.R568W; 1:22896415-22896415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1549G>A; p.G517R; 1:22893004-22893004	breast	carcinoma	Substitution - Missense
c.643G>A; p.E215K; 1:22784908-22784908	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1702C>T; p.R568W; 1:22896415-22896415	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1201C>A; p.H401N; 1:22865110-22865110	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.221G>A; p.R74Q; 1:22784486-22784486	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.534C>T; p.F178F; 1:22784799-22784799	skin	malignant_melanoma	Substitution - coding silent
c.221G>A; p.R74Q; 1:22784486-22784486	skin	malignant_melanoma	Substitution - Missense
c.1501G>A; p.G501S; 1:22892956-22892956	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1378G>A; p.D460N; 1:22882433-22882433	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1041C>T; p.P347P; 1:22864950-22864950	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.909T>C; p.C303C; 1:22863134-22863134	skin	malignant_melanoma	Substitution - coding silent
c.2098G>A; p.E700K; 1:22906919-22906919	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2680G>A; p.A894T; 1:22910559-22910559	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2454G>A; p.E818E; 1:22909123-22909123	liver	carcinoma	Substitution - coding silent
c.2364C>T; p.I788I; 1:22909033-22909033	skin	malignant_melanoma	Substitution - coding silent
c.3048C>T; p.D1016D; 1:22913750-22913750	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.411G>A; p.K137K; 1:22784676-22784676	skin	malignant_melanoma	Substitution - coding silent
c.548G>A; p.G183D; 1:22784813-22784813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1819G>A; p.E607K; 1:22906040-22906040	skin; scalp	malignant_melanoma	Substitution - Missense
c.1819G>A; p.E607K; 1:22906040-22906040	skin	malignant_melanoma	Substitution - Missense
c.1819G>A; p.E607K; 1:22906040-22906040	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1842G>A; p.K614K; 1:22906063-22906063	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.699G>A; p.V233V; 1:22784964-22784964	NS	malignant_melanoma	Substitution - coding silent
c.699G>A; p.V233V; 1:22784964-22784964	NS	malignant_melanoma	Substitution - coding silent
c.2097C>T; p.T699T; 1:22906918-22906918	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1031G>T; p.W344L; 1:22864940-22864940	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1923G>A; p.K641K; 1:22906744-22906744	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2860C>A; p.L954I; 1:22913469-22913469	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1818C>T; p.N606N; 1:22906039-22906039	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2259C>T; p.L753L; 1:22908075-22908075	skin	malignant_melanoma	Substitution - coding silent
c.65C>T; p.T22M; 1:22781424-22781424	pancreas	carcinoma	Substitution - Missense
c.91G>A; p.A31T; 1:22781450-22781450	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2724G>A; p.T908T; 1:22912471-22912471	skin	malignant_melanoma	Substitution - coding silent
c.1339C>T; p.R447C; 1:22882394-22882394	skin	malignant_melanoma	Substitution - Missense
c.729G>A; p.G243G; 1:22784994-22784994	skin	malignant_melanoma	Substitution - coding silent
c.65C>T; p.T22M; 1:22781424-22781424	kidney	other; neoplasm	Substitution - Missense
c.128G>T; p.W43L; 1:22784393-22784393	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1263G>T; p.S421S; 1:22865172-22865172	breast	carcinoma	Substitution - coding silent
c.2690C>T; p.S897F; 1:22910569-22910569	skin	malignant_melanoma	Substitution - Missense
c.579C>G; p.F193L; 1:22784844-22784844	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2008G>A; p.E670K; 1:22906829-22906829	skin	malignant_melanoma	Substitution - Missense
c.94G>A; p.E32K; 1:22781453-22781453	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1828C>T; p.R610W; 1:22906049-22906049	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.R392H; 1:22865084-22865084	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.R392H; 1:22865084-22865084	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.R392H; 1:22865084-22865084	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1175G>A; p.R392H; 1:22865084-22865084	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.2248C>T; p.R750C; 1:22908064-22908064	skin	malignant_melanoma	Substitution - Missense
c.2126C>T; p.S709F; 1:22906947-22906947	skin	malignant_melanoma	Substitution - Missense
c.1791C>T; p.I597I; 1:22906012-22906012	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3051delA; p.K1020fs*>36; 1:22913753-22913753	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2209C>T; p.L737L; 1:22908025-22908025	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3051delA; p.K1020fs*>36; 1:22913753-22913753	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2232C>T; p.H744H; 1:22908048-22908048	skin	malignant_melanoma	Substitution - coding silent
c.1345G>A; p.V449M; 1:22882400-22882400	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2495A>G; p.N832S; 1:22909164-22909164	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.614C>T; p.A205V; 1:22784879-22784879	skin; back	malignant_melanoma	Substitution - Missense
c.1277C>G; p.S426C; 1:22865186-22865186	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1071C>G; p.V357V; 1:22864980-22864980	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2665A>G; p.S889G; 1:22910544-22910544	breast	carcinoma	Substitution - Missense
c.2635A>G; p.T879A; 1:22910514-22910514	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.606G>T; p.Q202H; 1:22784871-22784871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2422G>A; p.D808N; 1:22909091-22909091	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2088G>A; p.M696I; 1:22906909-22906909	skin	malignant_melanoma	Substitution - Missense
c.2928G>A; p.A976A; 1:22913537-22913537	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1106G>A; p.R369Q; 1:22865015-22865015	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.2769G>T; p.E923D; 1:22912516-22912516	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2319C>T; p.D773D; 1:22908135-22908135	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1482C>T; p.T494T; 1:22892937-22892937	skin	malignant_melanoma	Substitution - coding silent
c.1044C>T; p.R348R; 1:22864953-22864953	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.262G>A; p.V88M; 1:22784527-22784527	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.262G>A; p.V88M; 1:22784527-22784527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.261C>T; p.H87H; 1:22784526-22784526	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.2620G>A; p.G874S; 1:22910499-22910499	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1843G>A; p.E615K; 1:22906064-22906064	skin; knee	malignant_melanoma	Substitution - Missense
c.261C>T; p.H87H; 1:22784526-22784526	breast	carcinoma	Substitution - coding silent
c.1843G>A; p.E615K; 1:22906064-22906064	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1843G>A; p.E615K; 1:22906064-22906064	skin	malignant_melanoma	Substitution - Missense
c.1843G>A; p.E615K; 1:22906064-22906064	skin	malignant_melanoma	Substitution - Missense
c.1843G>A; p.E615K; 1:22906064-22906064	skin	malignant_melanoma	Substitution - Missense
c.2620G>A; p.G874S; 1:22910499-22910499	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2682G>A; p.A894A; 1:22910561-22910561	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.153G>T; p.E51D; 1:22784418-22784418	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2818A>C; p.T940P; 1:22912565-22912565	urinary_tract; bladder	carcinoma	Substitution - Missense
c.603C>T; p.I201I; 1:22784868-22784868	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1246G>C; p.D416H; 1:22865155-22865155	prostate	carcinoma	Substitution - Missense
c.2905A>T; p.N969Y; 1:22913514-22913514	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]