| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2066 |
Name | ERBB4 |
Synonym | ALS19|HER4|p180erbB4;erb-b2 receptor tyrosine kinase 4;ERBB4;erb-b2 receptor tyrosine kinase 4 |
Definition | avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic |
Position | 2q33.3-q34 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 6611 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | ErbB4 signaling events;PID Curated;200009 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | ErbB receptor signaling network;PID Curated;200136 |
Pathway | g-secretase mediated erbb4 signaling pathway;PID BioCarta;100172 |
Disease | Schizophrenia;FunDO |
Disease | Cancer;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | PSYCH;GAD |
Disease | schizophrenia;GAD |
|
External Links |
|
Links to Entrez Gene | 2066 |
Links to all GeneRIF Items | 2066 |
Links to iHOP | 2066 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2066 : length: 3879 atgaagccggcgacaggactttgggtctgggtgagccttctcgtggcggcggggaccgtc cagcccagcgattctcagtcagtgtgtgcaggaacggagaataaactgagctctctctct gacctggaacagcagtaccgagccttgcgcaagtactatgaaaactgtgaggttgtcatg ggcaacctggagataaccagcattgagcacaaccgggacctctccttcctgcggtctgtt cgagaagtcacaggctacgtgttagtggctcttaatcagtttcgttacctgcctctggag aatttacgcattattcgtgggacaaaactttatgaggatcgatatgccttggcaatattt ttaaactacagaaaagatggaaactttggacttcaagaacttggattaaagaacttgaca gaaatcctaaatggtggagtctatgtagaccagaacaaattcctttgttatgcagacacc attcattggcaagatattgttcggaacccatggccttccaacttgactcttgtgtcaaca aatggtagttcaggatgtggacgttgccataagtcctgtactggccgttgctggggaccc acagaaaatcattgccagactttgacaaggacggtgtgtgcagaacaatgtgacggcaga tgctacggaccttacgtcagtgactgctgccatcgagaatgtgctggaggctgctcagga cctaaggacacagactgctttgcctgcatgaatttcaatgacagtggagcatgtgttact cagtgtccccaaacctttgtctacaatccaaccacctttcaactggagcacaatttcaat gcaaagtacacatatggagcattctgtgtcaagaaatgtccacataactttgtggtagat tccagttcttgtgtgcgtgcctgccctagttccaagatggaagtagaagaaaatgggatt aaaatgtgtaaaccttgcactgacatttgcccaaaagcttgtgatggcattggcacagga tcattgatgtcagctcagactgtggattccagtaacattgacaaattcataaactgtacc aagatcaatgggaatttgatctttctagtcactggtattcatggggacccttacaatgca attgaagccatagacccagagaaactgaacgtctttcggacagtcagagagataacaggt ttcctgaacatacagtcatggccaccaaacatgactgacttcagtgttttttctaacctg gtgaccattggtggaagagtactctatagtggcctgtccttgcttatcctcaagcaacag ggcatcacctctctacagttccagtccctgaaggaaatcagcgcaggaaacatctatatt actgacaacagcaacctgtgttattatcataccattaactggacaacactcttcagcaca atcaaccagagaatagtaatccgggacaacagaaaagctgaaaattgtactgctgaagga atggtgtgcaaccatctgtgttccagtgatggctgttggggacctgggccagaccaatgt ctgtcgtgtcgccgcttcagtagaggaaggatctgcatagagtcttgtaacctctatgat ggtgaatttcgggagtttgagaatggctccatctgtgtggagtgtgacccccagtgtgag aagatggaagatggcctcctcacatgccatggaccgggtcctgacaactgtacaaagtgc tctcattttaaagatggcccaaactgtgtggaaaaatgtccagatggcttacagggggca aacagtttcattttcaagtatgctgatccagatcgggagtgccacccatgccatccaaac tgcacccaagggtgtaacggtcccactagtcatgactgcatttactacccatggacgggc cattccactttaccacaacatgctagaactcccctgattgcagctggagtaattggtggg ctcttcattctggtcattgtgggtctgacatttgctgtttatgttagaaggaagagcatc aaaaagaaaagagccttgagaagattcttggaaacagagttggtggaaccattaactccc agtggcacagcacccaatcaagctcaacttcgtattttgaaagaaactgagctgaagagg gtaaaagtccttggctcaggtgcttttggaacggtttataaaggtatttgggtacctgaa ggagaaactgtgaagattcctgtggctattaagattcttaatgagacaactggtcccaag gcaaatgtggagttcatggatgaagctctgatcatggcaagtatggatcatccacaccta gtccggttgctgggtgtgtgtctgagcccaaccatccagctggttactcaacttatgccc catggctgcctgttggagtatgtccacgagcacaaggataacattggatcacaactgctg cttaactggtgtgtccagatagctaagggaatgatgtacctggaagaaagacgactcgtt catcgggatttggcagcccgtaatgtcttagtgaaatctccaaaccatgtgaaaatcaca gattttgggctagccagactcttggaaggagatgaaaaagagtacaatgctgatggagga aagatgccaattaaatggatggctctggagtgtatacattacaggaaattcacccatcag agtgacgtttggagctatggagttactatatgggaactgatgacctttggaggaaaaccc tatgatggaattccaacgcgagaaatccctgatttattagagaaaggagaacgtttgcct cagcctcccatctgcactattgacgtttacatggtcatggtcaaatgttggatgattgat gctgacagtagacctaaatttaaggaactggctgctgagttttcaaggatggctcgagac cctcaaagatacctagttattcagggtgatgatcgtatgaagcttcccagtccaaatgac agcaagttctttcagaatctcttggatgaagaggatttggaagatatgatggatgctgag gagtacttggtccctcaggctttcaacatcccacctcccatctatacttccagagcaaga attgactcgaataggaaccagtttgtataccgagatggaggttttgctgctgaacaagga gtgtctgtgccctacagagccccaactagcacaattccagaagctcctgtggcacagggt gctactgctgagatttttgatgactcctgctgtaatggcaccctacgcaagccagtggca ccccatgtccaagaggacagtagcacccagaggtacagtgctgaccccaccgtgtttgcc ccagaacggagcccacgaggagagctggatgaggaaggttacatgactcctatgcgagac aaacccaaacaagaatacctgaatccagtggaggagaacccttttgtttctcggagaaaa aatggagaccttcaagcattggataatcccgaatatcacaatgcatccaatggtccaccc aaggccgaggatgagtatgtgaatgagccactgtacctcaacacctttgccaacaccttg ggaaaagctgagtacctgaagaacaacatactgtcaatgccagagaaggccaagaaagcg tttgacaaccctgactactggaaccacagcctgccacctcggagcacccttcagcaccca gactacctgcaggagtacagcacaaaatatttttataaacagaatgggcggatccggcct attgtggcagagaatcctgaatacctctctgagttctccctgaagccaggcactgtgctg ccgcctccaccttacagacaccggaatactgtggtgtaa |
Protein Sequence |
>2066 : length: 1292 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST INQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYD GEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA NSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGG LFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKR VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQ SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMID ADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAE EYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQG ATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRD KPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTL GKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRP IVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV |