| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 2066 |
Name | ERBB4 |
Synonymous | ALS19|HER4|p180erbB4;erb-b2 receptor tyrosine kinase 4;ERBB4;erb-b2 receptor tyrosine kinase 4 |
Definition | avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4|human epidermal growth factor receptor 4|proto-oncogene-like protein c-ErbB-4|receptor tyrosine-protein kinase erbB-4|tyrosine kinase-type cell surface receptor HER4|v-erb-a erythroblastic |
Position | 2q33.3-q34 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
ErbB4(h) --> ErbB4-CTF(h) (processing) | ErbB4(h) + NRG1(h) <==> ErbB4(h):NRG1(h) (binding) | ErbB4(h) + ATP --> ErbB4(h){pY} + ADP (phosphorylation) | HB-EGF(h) + ErbB4(h) <==> HB-EGF(h):ErbB4(h) (binding) | NRG1-beta1(h) + ErbB4(h) <==> NRG1-beta1(h):ErbB4(h) (binding) | EGF(h):ErbB2(h) + ErbB4(h) <==> EGF(h):ErbB2(h):ErbB4(h) (binding) | ErbB4(h) + nrg3(m) <==> ErbB4(h):nrg3(m) (binding) | PSD-95(h) + ErbB4(h) <==> PSD-95(h):ErbB4(h) (binding) | ErbB4(h) + PSD93(h) <==> ErbB4(h):PSD93(h) (binding) | SAP102(h) + ErbB4(h) <==> SAP102(h):ErbB4(h) (binding) | beta2-syntrophin(h) + ErbB4(h) <==> beta2-syntrophin(h):ErbB4(h) (binding) | ErbB4(h) + PSD-95(m.s.) <==> ErbB4(h):PSD-95(m.s.) (binding) | LRIG1-xbb1(h) + ErbB4(h) <==> LRIG1-xbb1(h):ErbB4(h) (binding) | ErbB4(h) + ubiquitin(h) --> ErbB4(h){ub} (ubiquitination) | ErbB4(h) + Odin(h) <==> ErbB4(h):Odin(h) (binding) | ErbB4(h) + Fe65(h) <==> ErbB4(h):Fe65(h) (binding) | ErbB4(h) + FE65L1(h) <==> ErbB4(h):FE65L1(h) (binding) | ErbB4(h) + APPL(h) <==> ErbB4(h):APPL(h) (binding) | ErbB4(h) + APS(h) <==> ErbB4(h):APS(h) (binding) | ErbB4(h) + BCAR-3(h) <==> ErbB4(h):BCAR-3(h) (binding) | ErbB4(h) + BLNK(h) <==> ErbB4(h):BLNK(h) (binding) | ErbB4(h) + RHOGAP2(h) <==> ErbB4(h):RHOGAP2(h) (binding) | ErbB4(h) + Cajalin-2(h) <==> ErbB4(h):Cajalin-2(h) (binding) | ErbB4(h) + fer(h) <==> ErbB4(h):fer(h) (binding) | ErbB4(h) + BSK(h) <==> ErbB4(h):BSK(h) (binding) | ErbB4(h) + IRS-1(h) <==> ErbB4(h):IRS-1(h) (binding) | ErbB4(h) + IRS-4(h) <==> ErbB4(h):IRS-4(h) (binding) | ErbB4(h) + Jak1(h) <==> ErbB4(h):Jak1(h) (binding) | ErbB4(h) + JIP1(h) <==> ErbB4(h):JIP1(h) (binding) | ErbB4(h) + JIP-2(h) <==> ErbB4(h):JIP-2(h) (binding) | ErbB4(h) + CHK(h) <==> ErbB4(h):CHK(h) (binding) | ErbB4(h) + PLCgamma2(h) <==> ErbB4(h):PLCgamma2(h) (binding) | ErbB4(h) + PTK6(h) <==> ErbB4(h):PTK6(h) (binding) | ErbB4(h) + SH2D1A(h) <==> ErbB4(h):SH2D1A(h) (binding) | ErbB4(h) + VRAP(h) <==> ErbB4(h):VRAP(h) (binding) | ErbB4(h) + 3BP2(h) <==> ErbB4(h):3BP2(h) (binding) | ErbB4(h) + Shb(h) <==> ErbB4(h):Shb(h) (binding) | Shc-3(h) + ErbB4(h) <==> Shc-3(h):ErbB4(h) (binding) | ErbB4(h) + STAT1(h) <==> ErbB4(h):STAT1(h) (binding) | ErbB4(h) + STAT3(h) <==> ErbB4(h):STAT3(h) (binding) | ErbB4(h) + C1-TEN(h) <==> ErbB4(h):C1-TEN(h) (binding) | ErbB4(h) + Txk(h) <==> ErbB4(h):Txk(h) (binding) | ErbB4(h) --> protein remnants (degradation) | ErbB4(h) + muc1(h) <==> ErbB4(h):muc1(h) (binding) | ErbB4(h) + ErbB2(h) <==> ErbB4(h):ErbB2(h) (binding) | ErbB4(h) + ATP --ErbB2(h)--> ErbB4(h){pY} + ADP (phosphorylation) | ErbB1(h) + ErbB4(h) <==> ErbB1(h):ErbB4(h) (binding) | ErbB4(h) + ErbB3(h) <==> ErbB4(h):ErbB3(h) (binding) | ErbB2(h) + ErbB4(h) <==> ErbB2(h):ErbB4(h) (binding) | ErbB4(h) + proEPR(h) <==> ErbB4(h):proEPR(h) (binding) | ErbB4(h) + Fyn(h) <==> ErbB4(h):Fyn(h) (binding) | ErbB4(h) + Fyn-isoform1(h) <==> ErbB4(h):Fyn-isoform1(h) (binding) | STAT5A(m) + ErbB4(h) <==> STAT5A(m):ErbB4(h) (binding) | ErbB4(h) + BTC(h) <==> ErbB4(h):BTC(h) (binding) | HPRG(m.s.) + ErbB4(h) <==> HPRG(m.s.):ErbB4(h) (binding) | Nrdp1(m.s.) + ErbB4(h) <==> Nrdp1(m.s.):ErbB4(h) (binding) | ErbB4(h) + ATP --> ErbB4(h){p} + ADP (phosphorylation; automodification) | ERBB4(h) --> ErbB4(h) (expression). | NRG1(h) --/ ErbB4(h) (decrease of abundance) | ErbB2(h) + ATP --ErbB4(h)--> ErbB2(h){pY} + ADP (phosphorylation) | ErbB4-JM-A(h) + 10 ATP --ErbB1-p170(h)--> ErbB4-JM-A(h){pY1022}{pY1056}{pY1150}{pY1162}{pY1188}{pY1202}{pY1221}{pY1242}{pY1258}{pY1284} + 10 ADP (phosphorylation) | ErbB4-JM-A(h) + STAT5A(m) <==> ErbB4-JM-A(h):STAT5A(m) (binding) | STAT5A(m.s.) + ErbB4-JM-A(h) <==> STAT5A(m.s.):ErbB4-JM-A(h) (binding) | ErbB4-JM-A(h) + ATP --> ErbB4-JM-A(h){pY} + ADP (phosphorylation) | ErbB4-JM-A(h) + ATP --> ErbB4-JM-A(h){p} + ADP (phosphorylation; automodification) | ERBB4(h) --> ErbB4-JM-A(h) (expression). | ErbB4-JM-B(h) + ATP --> ErbB4-JM-B(h){pY} + ADP (phosphorylation) | ERBB4(h) --> ErbB4-JM-B(h) (expression). | ERBB4(h) --> ErbB4-isoform3(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
138 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 174 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 181 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 253 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 358 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 410 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 473 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 495 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 548 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 576 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 620 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1162 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1188 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1258 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1284 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1056 | Phosphotyrosine | 8617750 | Phospho.ELM 6.0 | 1284 | Phosphotyrosine | 8617750 | Phospho.ELM 6.0 | 1242 | Phosphotyrosine | 8617750 | Phospho.ELM 6.0 | 1188 | Phosphotyrosine | 8617750 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 213111097 - 213113097 | Agilent_014791 |
chr2 |
Promoter: 213111097 - 213113097 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 213111097 - 213113097 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 213111097 - 213113097 | GSE27584 |
chr2 |
Promoter: 213111097 - 213113097 | GSE27584 |
chr2 |
Promoter: 213111097 - 213113097 | Agilent_014791_44K |