| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2934 |
Name | GSN |
Synonym | ADF|AGEL;gelsolin;GSN;gelsolin |
Definition | actin-depolymerizing factor|brevin |
Position | 9q33 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 8098 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | rho cell motility signaling pathway;PID BioCarta;100041 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | Caspase-mediated cleavage of cytoskeletal proteins;PID Reactome;500271 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Disease | Amyloidosis, Finnish type;OMIM |
|
External Links |
|
Links to Entrez Gene | 2934 |
Links to all GeneRIF Items | 2934 |
Links to iHOP | 2934 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>2934 : length: 2349 atggctccgcaccgccccgcgcccgcgctgctttgcgcgctgtccctggcgctgtgcgcg ctgtcgctgcccgtccgcgcggccactgcgtcgcggggggcgtcccaggcgggggcgccc caggggcgggtgcccgaggcgcggcccaacagcatggtggtggaacaccccgagttcctc aaggcagggaaggagcctggcctgcagatctggcgtgtggagaagttcgatctggtgccc gtgcccaccaacctttatggagacttcttcacgggcgacgcctacgtcatcctgaagaca gtgcagctgaggaacggaaatctgcagtatgacctccactactggctgggcaatgagtgc agccaggatgagagcggggcggccgccatctttaccgtgcagctggatgactacctgaac ggccgggccgtgcagcaccgtgaggtccagggcttcgagtcggccaccttcctaggctac ttcaagtctggcctgaagtacaagaaaggaggtgtggcatcaggattcaagcacgtggta cccaacgaggtggtggtgcagagactcttccaggtcaaagggcggcgtgtggtccgtgcc accgaggtacctgtgtcctgggagagcttcaacaatggcgactgcttcatcctggacctg ggcaacaacatccaccagtggtgtggttccaacagcaatcggtatgaaagactgaaggcc acacaggtgtccaagggcatccgggacaacgagcggagtggccgggcccgagtgcacgtg tctgaggagggcactgagcccgaggcgatgctccaggtgctgggccccaagccggctctg cctgcaggtaccgaggacaccgccaaggaggatgcggccaaccgcaagctggccaagctc tacaaggtctccaatggtgcagggaccatgtccgtctccctcgtggctgatgagaacccc ttcgcccagggggccctgaagtcagaggactgcttcatcctggaccacggcaaagatggg aaaatctttgtctggaaaggcaagcaggcaaacacggaggagaggaaggctgccctcaaa acagcctctgacttcatcaccaagatggactaccccaagcagactcaggtctcggtcctt cctgagggcggtgagaccccactgttcaagcagttcttcaagaactggcgggacccagac cagacagatggcctgggcttgtcctacctttccagccatatcgccaacgtggagcgggtg cccttcgacgccgccaccctgcacacctccactgccatggccgcccagcacggcatggat gacgatggcacaggccagaaacagatctggagaatcgaaggttccaacaaggtgcccgtg gaccctgccacatatggacagttctatggaggcgacagctacatcattctgtacaactac cgccatggtggccgccaggggcagataatctataactggcagggtgcccagtctacccag gatgaggtcgctgcatctgccatcctgactgctcagctggatgaggagctgggaggtacc cctgtccagagccgtgtggtccaaggcaaggagcccgcccacctcatgagcctgtttggt gggaagcccatgatcatctacaagggcggcacctcccgcgagggcgggcagacagcccct gccagcacccgcctcttccaggtccgcgccaacagcgctggagccacccgggctgttgag gtattgcctaaggctggtgcactgaactccaacgatgcctttgttctgaaaaccccctca gccgcctacctgtgggtgggtacaggagccagcgaggcagagaagacgggggcccaggag ctgctcagggtgctgcgggcccaacctgtgcaggtggcagaaggcagcgagccagatggc ttctgggaggccctgggcgggaaggctgcctaccgcacatccccacggctgaaggacaag aagatggatgcccatcctcctcgcctctttgcctgctccaacaagattggacgttttgtg atcgaagaggttcctggtgagctcatgcaggaagacctggcaacggatgacgtcatgctt ctggacacctgggaccaggtctttgtctgggttggaaaggattctcaagaagaagaaaag acagaagccttgacttctgctaagcggtacatcgagacggacccagccaatcgggatcgg cggacgcccatcaccgtggtgaagcaaggctttgagcctccctcctttgtgggctggttc cttggctgggatgatgattactggtctgtggaccccttggacagggccatggctgagctg gctgcctga |
Protein Sequence |
>2934 : length: 782 MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFL KAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNEC SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA TQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKL YKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALK TASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERV PFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY RHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFG GKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPS AAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDK KMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEK TEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAEL AA |