| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3172 |
Name | HNF4A |
Synonym | FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14;hepatocyte nuclear factor 4, alpha;HNF4A;hepatocyte nuclear factor 4, alpha |
Definition | HNF4alpha10/11/12|TCF-14|hepatic nuclear factor 4 alpha|hepatocyte nuclear factor 4-alpha|nuclear receptor subfamily 2 group A member 1|transcription factor 14|transcription factor HNF-4 |
Position | 20q13.12 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 8497 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Maturity onset diabetes of the young;KEGG PATHWAY;hsa04950 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | FOXA2 and FOXA3 transcription factor networks;PID Curated;200073 |
Pathway | Regulation of beta-cell development;Reactome;REACT:13698 |
Pathway | Gene Expression;Reactome;REACT:71 |
Disease | Maturity onset diabetes of the young (MODY);KEGG DISEASE;H00410 |
Disease | METABOLIC;GAD |
Disease | diabetes, type 2;GAD |
Disease | Metabolic diseases;KEGG DISEASE |
Disease | Diabetes mellitus;FunDO |
Disease | birth weight hypoglycemia;GAD |
Disease | IMMUNE;GAD |
Disease | cholesterol metabolic syndrome triglycerides;GAD |
Disease | Hyperinsulinism;FunDO |
Disease | HDL cholesterol;NHGRI |
Disease | Ulcerative colitis;NHGRI |
Disease | Pancreas disease;FunDO |
Disease | plasma HDL cholesterol (HDL-C) levels;GAD |
Disease | MODY, type I;OMIM |
Disease | HDL cholesterol;GAD |
Disease | Diabetes;KEGG DISEASE |
Disease | ulcerative colitis;GAD |
Disease | Diabetes mellitus, noninsulin-dependent;OMIM |
Disease | Metabolism disease;FunDO |
|
External Links |
|
Links to Entrez Gene | 3172 |
Links to all GeneRIF Items | 3172 |
Links to iHOP | 3172 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>3172 : length: 1425 atgcgactctccaaaaccctcgtcgacatggacatggccgactacagtgctgcactggac ccagcctacaccaccctggaatttgagaatgtgcaggtgttgacgatgggcaatgacacg tccccatcagaaggcaccaacctcaacgcgcccaacagcctgggtgtcagcgccctgtgt gccatctgcggggaccgggccacgggcaaacactacggtgcctcgagctgtgacggctgc aagggcttcttccggaggagcgtgcggaagaaccacatgtactcctgcagatttagccgg cagtgcgtggtggacaaagacaagaggaaccagtgccgctactgcaggctcaagaaatgc ttccgggctggcatgaagaaggaagccgtccagaatgagcgggaccggatcagcactcga aggtcaagctatgaggacagcagcctgccctccatcaatgcgctcctgcaggcggaggtc ctgtcccgacagatcacctcccccgtctccgggatcaacggcgacattcgggcgaagaag attgccagcatcgcagatgtgtgtgagtccatgaaggagcagctgctggttctcgttgag tgggccaagtacatcccagctttctgcgagctccccctggacgaccaggtggccctgctc agagcccatgctggcgagcacctgctgctcggagccaccaagagatccatggtgttcaag gacgtgctgctcctaggcaatgactacattgtccctcggcactgcccggagctggcggag atgagccgggtgtccatacgcatccttgacgagctggtgctgcccttccaggagctgcag atcgatgacaatgagtatgcctacctcaaagccatcatcttctttgacccagatgccaag gggctgagcgatccagggaagatcaagcggctgcgttcccaggtgcaggtgagcttggag gactacatcaacgaccgccagtatgactcgcgtggccgctttggagagctgctgctgctg ctgcccaccttgcagagcatcacctggcagatgatcgagcagatccagttcatcaagctc ttcggcatggccaagattgacaacctgttgcaggagatgctgctgggagggtcccccagc gatgcaccccatgcccaccaccccctgcaccctcacctgatgcaggaacatatgggaacc aacgtcatcgttgccaacacaatgcccactcacctcagcaacggacagatgtgtgagtgg ccccgacccaggggacaggcagccacccctgagaccccacagccctcaccgccaggtggc tcagggtctgagccctataagctcctgccgggagccgtcgccacaatcgtcaagcccctc tctgccatcccccagccgaccatcaccaagcaggaagttatctag |
Protein Sequence |
>3172 : length: 474 MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALC AICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKC FRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKK IASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFK DVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAK GLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKL FGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEW PRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI |