| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3172 |
Name | HNF4A |
Synonymous | FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14;hepatocyte nuclear factor 4, alpha;HNF4A;hepatocyte nuclear factor 4, alpha |
Definition | HNF4alpha10/11/12|TCF-14|hepatic nuclear factor 4 alpha|hepatocyte nuclear factor 4-alpha|nuclear receptor subfamily 2 group A member 1|transcription factor 14|transcription factor HNF-4 |
Position | 20q13.12 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
HNF-4alpha2(h) --> CEACAM1(h) (DNA binding; transregulation). | HNF-4alpha3(h) + HNF-4alpha2(h) <==> HNF-4alpha3(h):HNF-4alpha2(h) (binding). | HNF-4alpha2(h) + HIF-1alpha(h) <==> HNF-4alpha2(h):HIF-1alpha(h) (binding) | HNF-4alpha2(h) + arnt(h) <==> HNF-4alpha2(h):arnt(h) (binding) | HNF-4alpha2(h) --> Pklr(r) (DNA binding). | HNF-4alpha2(h) + islet1(r) <==> HNF-4alpha2(h):islet1(r) (binding) | HNF-4alpha2(h) + LIMK1(m.s.) <==> HNF-4alpha2(h):LIMK1(m.s.) (binding) | HNF-4alpha2(h) --> TCF1(h) (transactivation) | HNF-4alpha2(h) --> PPARA(h) (transactivation) | HNF-4alpha2(h) --> ins-1(r) (transactivation) | HNF-4alpha2(h) + islet1-isoform1(r) <==> HNF-4alpha2(h):islet1-isoform1(r) (binding) | HNF-4alpha2(h) --> CYP8B1(h) (DNA binding; transactivation). | HNF-4alpha2(h) --> Dio1(m) (DNA binding; transactivation). | HNF-4alpha2(h) --> SLC22A6(h) (DNA binding; transactivation). | HNF4A(h) --> HNF-4alpha2(h) (expression). | HNF-4alpha1(h) --> CEACAM1(h) (DNA binding; transregulation). | HNF-4alpha1(h) + HNF-4alpha3(h) <==> HNF-4alpha1(h):HNF-4alpha3(h) (binding). | HNF-4alpha1(h) --> Onecut1(r) (DNA binding; transactivation). | HNF-4alpha1(h) --> PPARA(h) (DNA binding; transregulation). | HNF-4alpha1(h) --> LIPC(h) (DNA binding). | HNF-4alpha1(h) + TRIP-3(h) <==> HNF-4alpha1(h):TRIP-3(h) (binding) | HNF4A(h) --> HNF-4alpha1(h) (expression). | HNF-4alpha4(h) --> CEACAM1(h) (DNA binding; transregulation). | HNF4A(h) --> HNF-4alpha4(h) (expression). | HNF-4alpha3(h) --> CEACAM1(h) (DNA binding; transregulation). | HNF-4alpha3(h) + HNF-4alpha2(h) <==> HNF-4alpha3(h):HNF-4alpha2(h) (binding). | HNF-4alpha1(h) + HNF-4alpha3(h) <==> HNF-4alpha1(h):HNF-4alpha3(h) (binding). | HNF-4alpha3(h) + islet1(r) <==> HNF-4alpha3(h):islet1(r) (binding) | HNF4A(h) --> HNF-4alpha3(h) (expression). | HNF-4(h) --> HNF-1(r) (DNA binding). | HNF-4(h) --> apoCIII(h) (DNA binding). | HNF-4(h) --> GUCY2C(h) (DNA binding). | HNF-4(h) + acetyl-CoA --CBP(h)--> HNF-4(h){ace} + CoA (acetylation) | CBP(h) + HNF-4(h) <==> CBP(h):HNF-4(h) (binding) | HNF-4(h) --> apoB(h) (DNA binding; transactivation). | HNF-4(h) --> Epo(h) (DNA binding; transactivation). | HNF-4(h) --> Cyp7a1(r) (DNA binding; transactivation). | HNF-4(h) --> CYP8B1(r) (DNA binding; transactivation). | HNF-4(h) --> Cyp7A(gl) (DNA binding; transactivation). | HNF-4(h) --> SERPINC1(h) (DNA binding). | HNF-4(h) --> F10(h) (DNA binding). | HNF-4(h) --> F12(h) (DNA binding). | HNF-4(h) --> MST1(h) (DNA binding; transregulation). | HNF-4(h) --> PPARA(h) (DNA binding). | HNF-4(h) --> SHBG(h) (DNA binding). | HNF-4(h) --> CYP2C9(h) (DNA binding; transactivation). | HNF-4(h) --> CYP2D6(h) (DNA binding). | HNF-4(h) --> F2(h) (DNA binding). | HNF-4(h) --> CYP2C8(h) (DNA binding; transactivation). | HNF-4(h) --> apoC-II(h) (DNA binding). | HNF4A(h) --> HNF-4(h) (expression). | HNF-4alpha(h) --> Cpt1a(r) (DNA binding; transactivation). | HNF-4alpha(h) --> F11(h) (DNA binding; transactivation). | HNF-4alpha(h) --> AKR1C4(h) (DNA binding; transactivation). | HNF-4alpha(h) --> F7(h) (DNA binding). | HNF-4alpha(h) + Smad3(h) <==> HNF-4alpha(h):Smad3(h) (binding). | HNF-4alpha(h) + smad4(h) <==> HNF-4alpha(h):smad4(h) (binding). | PGC-1(h) + HNF-4alpha(h) <==> PGC-1(h):HNF-4alpha(h) (binding). | PGC-1(m) + HNF-4alpha(h) <==> PGC-1(m):HNF-4alpha(h) (binding). | HNF-4alpha(h) + Smad3(h):smad4(h) <==> HNF-4alpha(h):Smad3(h):smad4(h) (binding). | HNF-4alpha(h) --> HMOX1(h) (DNA binding; transactivation). | HNF-4alpha(h) --> AMBP(h) (DNA binding). | HNF-4alpha(h) --> GK(h) (DNA binding; transactivation). | HNF-4alpha(h) --> CYP3A4(h) (DNA binding; transactivation). | HNF-4alpha(h) --> CYP27A1(h) (DNA binding; transactivation). | HNF-4alpha(h) --> CYP8B1(h) (DNA binding). | HNF-4alpha(h) + SREBP-2(h) <==> HNF-4alpha(h):SREBP-2(h) (binding) | HNF-4alpha(h) --> TCF1(h) (DNA binding; transactivation). | HNF-4alpha(h) --> Cyp2a5(m) (DNA binding; transactivation). | HNF-4alpha(h) --> LIPC(h) (DNA binding; transactivation). | HNF-4alpha(h) --> apoAI(h) (DNA binding; transactivation). | HNF-4alpha(h) --> CYP2D6(h) (DNA binding). | HNF-4alpha(h) --> apoC-II(h) (DNA binding). | lauric acid + HNF-4alpha(h) <==> lauric acid:HNF-4alpha(h) (binding) | myristic acid + HNF-4alpha(h) <==> myristic acid:HNF-4alpha(h) (binding) | palmitic acid + HNF-4alpha(h) <==> palmitic acid:HNF-4alpha(h) (binding) | palmitoleic acid + HNF-4alpha(h) <==> palmitoleic acid:HNF-4alpha(h) (binding) | HNF-4alpha(h) --> alpha1-AT(h) (DNA binding). | HNF-4alpha(h) --> apoB(h) (DNA binding). | HNF-4alpha(h) --> HNF-1(r) (DNA binding). | HNF-4alpha(h) --> AGT(h) (DNA binding). | HNF-4alpha(h) --> FABP2(h) (DNA binding). | HNF-4alpha(h) --> PAK7(h) (DNA binding). | HNF-4alpha(h) --> SLC22A1(h) (DNA binding). | HNF-4alpha(h) --> RPS6KA6(h) (DNA binding). | HNF-4alpha(h) + ATP --p38(m.s.)--> HNF-4alpha(h){pS158} + ADP (phosphorylation) | HNF-4alpha(h) + ATP --ERK(m.s.)--> HNF-4alpha(h){p} + ADP (phosphorylation) | HNF-4alpha(h) + ATP --JNK(m.s.)--> HNF-4alpha(h){p} + ADP (phosphorylation) | HNF-4alpha(h) --> HNF4A(h) (DNA binding). | HNF-4alpha(h) --> SLC22A7(h) (DNA binding). | HIF-1alpha(h) + HNF-4alpha(h) <==> HIF-1alpha(h):HNF-4alpha(h) (binding) | HNF-4alpha(h) + SRC-1(m.s.) <==> HNF-4alpha(h):SRC-1(m.s.) (binding) | HNF-4alpha(h) + prox1(h) <==> HNF-4alpha(h):prox1(h) (binding) | HNF-4alpha(h) + gamma-synuclein(h) <==> HNF-4alpha(h):gamma-synuclein(h) (binding) | HNF-4alpha(h) + exostosin-2(h) <==> HNF-4alpha(h):exostosin-2(h) (binding) | HNF-4alpha(h) + MPSK(h) <==> HNF-4alpha(h):MPSK(h) (binding) | HNF-4alpha(h) + Rad50(h) <==> HNF-4alpha(h):Rad50(h) (binding) | HNF-4alpha(h) + APP1(h) <==> HNF-4alpha(h):APP1(h) (binding) | HNF-4alpha(h) --> NR1i3(m) (transactivation) | PNRC(h) + HNF-4alpha(h) <==> PNRC(h):HNF-4alpha(h) (binding) | HNF-4alpha(h) + PNRC2(h) <==> HNF-4alpha(h):PNRC2(h) (binding) | HNF-4alpha(h) + ASC-2(h) <==> HNF-4alpha(h):ASC-2(h) (binding) | HNF-4alpha(h) + RIP140(h) <==> HNF-4alpha(h):RIP140(h) (binding) | HNF-4alpha(h) + SHP(h) <==> HNF-4alpha(h):SHP(h) (binding) | Ubc9(h) + HNF-4alpha(h) <==> Ubc9(h):HNF-4alpha(h) (binding) | HNF-4alpha(h) + JAB1(h) <==> HNF-4alpha(h):JAB1(h) (binding) | HNF-4alpha(h) --> apoCIII(h) (DNA binding). | HNF-4alpha(h) --> apoA-IV(h) (DNA binding). | HNF-4alpha(h) --> Cyp7a1(r) (DNA binding). | HNF-4alpha(h) --> CES2(m) (DNA binding). | 2 HNF-4alpha(h) <==> (HNF-4alpha(h))2 (binding) | HNF-4alpha(h) --> SLC10A1(h) (transactivation) | HNF-4alpha(h) --> Abcg5(h) (DNA binding; transactivation). | HNF-4alpha(h) --> ABCG8(h) (DNA binding; transactivation). | HNF-4alpha(h) --> Slc10a1(r) (DNA binding). | HNF-4alpha(h) --> Abcb4(r) (DNA binding). | HNF-4alpha(h) --> TTR(h) (DNA binding). | HNF-4alpha(h) --> ABCC1(h) (DNA binding). | HNF-4alpha(h) --> Apoa5(h) (DNA binding). | HNF-4alpha(h) --> Dio1(m) (DNA binding; transactivation). | HNF-4alpha(h) --> ABCB4(h) (DNA binding). | HNF-4alpha(h) --> Abcb4(m) (DNA binding). | HNF-4alpha(h) --> Abcc1(m) (DNA binding). | HNF-4alpha(h) --> Abcc1(r) (DNA binding). | HNF-4alpha(h) --> PLCB1(h) (DNA binding). | HNF-4alpha(h) --> TRPC1(h) (DNA binding). | HNF-4alpha(h) --> Plcb1(r) (DNA binding). | HNF-4alpha(h) --> Trpc1(r) (DNA binding). | GR(h) + HNF-4alpha(h) <==> HNF-4alpha(h):GR(h) (binding) | HNF-4alpha(h) --> Pck1(r) (DNA binding). | HNF-4alpha(h) --> GFER(h) (DNA binding). | HNF-4alpha(h) --> CYP2A6(h) (DNA binding). | HNF-4alpha(h) --> SEPP1(h) (DNA binding). | HNF-4alpha(h) --> GUCY2C(h) (DNA binding). | HNF-4alpha(h) --> NR1I2(h) (DNA binding; transactivation). | HNF-4alpha(h) --> Hsd17b7(h) (DNA binding). | HNF-4alpha(h) --> SLC28A1(h) (DNA binding; transactivation). | HNF4A(h) --> HNF-4alpha(h) (expression). | HNF4A(h) --> HNF-4alpha7(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
429 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 432 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 133 | Phosphoserine | 16351573 | Phospho.ELM 6.0 | 134 | Phosphoserine | 16351573 | Phospho.ELM 6.0 | 158 | Phosphoserine (MAPK11) | 16351573 | Phospho.ELM 6.0 | 181 | Phosphoserine | 16351573 | Phospho.ELM 6.0 | 460 | Phosphothreonine | 16351573 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr20 |
Promoter: 42416355 - 42418355 | GSE27584 |
chr20 |
Promoter: 42416355 - 42418355 | GSE27584 |
chr20 |
Promoter: 42416355 - 42418355 | GSE27584 |
chr20 |
Promoter: 42461838 - 42463838 | GSE27584 |
chr20 |
Promoter: 42461838 - 42463838 | GSE27584 |
chr20 |
Promoter: 42461838 - 42463838 | GSE27584 |
chr20 |
Promoter: 42461838 - 42463838 | E-GEOD-20553 |
chr20 |
Promoter: 42416355 - 42418355 | E-GEOD-20553 |
chr20 |
Promoter: 42416355 - 42418355 | E-GEOD-20553 |
chr20 |
Promoter: 42416355 - 42418355 | E-GEOD-20553 |
chr20 |
Promoter: 42461838 - 42463838 | E-GEOD-20553 |
chr20 |
Promoter: 42461838 - 42463838 | E-GEOD-20553 |