Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

324

Name

APC

Synonym

BTPS2|DP2|DP2.5|DP3|GS|PPP1R46;adenomatous polyposis coli;APC;adenomatous polyposis coli

Definition

adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46

Position

5q21-q22

Gene Type

protein-coding

TSG scores

Description

TUSON ranking

5

TUSON P-value

2.98E-86

Pathways and Diseases

Pathway

Presenilin action in Notch and Wnt signaling;PID Curated;200052

Pathway

Wnt signaling pathway;KEGG PATHWAY;hsa04310

Pathway

Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106

Pathway

Apoptosis;Reactome;REACT:578

Pathway

Canonical Wnt signaling pathway;PID Curated;200064

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

CDC42 signaling events;PID Curated;200057

Pathway

Wnt signaling pathway;PANTHER;P00057

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

Signaling by Wnt;Reactome;REACT:11045

Pathway

Regulation of CDC42 activity;PID Curated;200059

Pathway

Basal cell carcinoma;KEGG PATHWAY;hsa05217

Pathway

Angiogenesis;PANTHER;P00005

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Disease

colon adenomas/carcinomas;GAD

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

late onset of familial adenomatous polyposis;GAD

Disease

Adenomatous polyposis coli;OMIM

Disease

Gastric cancer, somatic;OMIM

Disease

decreased apoptotic level;GAD

Disease

Brain tumor-polyposis syndrome 2;OMIM

Disease

hepatocellular carcinoma;GAD

Disease

Pervasive development disorder;FunDO

Disease

Hepatoblastoma;OMIM

Disease

Ulcerative colitis;FunDO

Disease

Desmoid disease, hereditary;OMIM

Disease

Cancer of the anal canal;KEGG DISEASE;H00044

Disease

Colorectal cancer, somatic;OMIM

Disease

beta-catenin;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Schizophrenia;FunDO

Disease

Adenomatous Polyposis Coli;GAD

Disease

colorectal cancer;GAD

Disease

PSYCH;GAD

Disease

adenomatous polyposis;GAD

Disease

colorectal adenocarcinomas;GAD

Disease

Venous Thrombosis;GAD

Disease

CARDIOVASCULAR;GAD

Disease

CANCER;GAD

Disease

familial adenomatous polyposis.;GAD

Disease

severe desmoid phenotype;GAD

Disease

Adenoma, periampullary;OMIM

Disease

colorectal adenomas;GAD

Disease

Gallbladder cancer;KEGG DISEASE;H00047

Disease

late onset familial adenomatous polyposis;GAD

Disease

diet lifestyle and risk of colon cancer;GAD

Disease

Cancers;KEGG DISEASE

Disease

stomach cancer;GAD

Disease

Barrett's esophagus;FunDO

Disease

Congenital abnormality;FunDO

Disease

Autism;GAD

Disease

Cancer;FunDO

Disease

Esophageal cancer;KEGG DISEASE;H00017

Disease

Gardner syndrome;OMIM

External Links

Links to Entrez Gene

324

Links to all GeneRIF Items

324

Links to iHOP

324

Sequence Information

The sequences provided here are only the longest representative sequences, not covering all the isoforms.

Nucleotide Sequence

>324 : length: 8532
atggctgcagcttcatatgatcagttgttaaagcaagttgaggcactgaagatggagaac
tcaaatcttcgacaagagctagaagataattccaatcatcttacaaaactggaaactgag
gcatctaatatgaaggaagtacttaaacaactacaaggaagtattgaagatgaagctatg
gcttcttctggacagattgatttattagagcgtcttaaagagcttaacttagatagcagt
aatttccctggagtaaaactgcggtcaaaaatgtccctccgttcttatggaagccgggaa
ggatctgtatcaagccgttctggagagtgcagtcctgttcctatgggttcatttccaaga
agagggtttgtaaatggaagcagagaaagtactggatatttagaagaacttgagaaagag
aggtcattgcttcttgctgatcttgacaaagaagaaaaggaaaaagactggtattacgct
caacttcagaatctcactaaaagaatagatagtcttcctttaactgaaaatttttcctta
caaacagatatgaccagaaggcaattggaatatgaagcaaggcaaatcagagttgcgatg
gaagaacaactaggtacctgccaggatatggaaaaacgagcacagcgaagaatagccaga
attcagcaaatcgaaaaggacatacttcgtatacgacagcttttacagtcccaagcaaca
gaagcagagaggtcatctcagaacaagcatgaaaccggctcacatgatgctgagcggcag
aatgaaggtcaaggagtgggagaaatcaacatggcaacttctggtaatggtcagggttca
actacacgaatggaccatgaaacagccagtgttttgagttctagtagcacacactctgca
cctcgaaggctgacaagtcatctgggaaccaaggtggaaatggtgtattcattgttgtca
atgcttggtactcatgataaggatgatatgtcgcgaactttgctagctatgtctagctcc
caagacagctgtatatccatgcgacagtctggatgtcttcctctcctcatccagctttta
catggcaatgacaaagactctgtattgttgggaaattcccggggcagtaaagaggctcgg
gccagggccagtgcagcactccacaacatcattcactcacagcctgatgacaagagaggc
aggcgtgaaatccgagtccttcatcttttggaacagatacgcgcttactgtgaaacctgt
tgggagtggcaggaagctcatgaaccaggcatggaccaggacaaaaatccaatgccagct
cctgttgaacatcagatctgtcctgctgtgtgtgttctaatgaaactttcatttgatgaa
gagcatagacatgcaatgaatgaactagggggactacaggccattgcagaattattgcaa
gtggactgtgaaatgtatgggcttactaatgaccactacagtattacactaagacgatat
gctggaatggctttgacaaacttgacttttggagatgtagccaacaaggctacgctatgc
tctatgaaaggctgcatgagagcacttgtggcccaactaaaatctgaaagtgaagactta
cagcaggttattgcgagtgttttgaggaatttgtcttggcgagcagatgtaaatagtaaa
aagacgttgcgagaagttggaagtgtgaaagcattgatggaatgtgctttagaagttaaa
aaggaatcaaccctcaaaagcgtattgagtgccttatggaatttgtcagcacattgcact
gagaataaagctgatatatgtgctgtagatggtgcacttgcatttttggttggcactctt
acttaccggagccagacaaacactttagccattattgaaagtggaggtgggatattacgg
aatgtgtccagcttgatagctacaaatgaggaccacaggcaaatcctaagagagaacaac
tgtctacaaactttattacaacacttaaaatctcatagtttgacaatagtcagtaatgca
tgtggaactttgtggaatctctcagcaagaaatcctaaagaccaggaagcattatgggac
atgggggcagttagcatgctcaagaacctcattcattcaaagcacaaaatgattgctatg
ggaagtgctgcagctttaaggaatctcatggcaaataggcctgcgaagtacaaggatgcc
aatattatgtctcctggctcaagcttgccatctcttcatgttaggaaacaaaaagcccta
gaagcagaattagatgctcagcacttatcagaaacttttgacaatatagacaatttaagt
cccaaggcatctcatcgtagtaagcagagacacaagcaaagtctctatggtgattatgtt
tttgacaccaatcgacatgatgataataggtcagacaattttaatactggcaacatgact
gtcctttcaccatatttgaatactacagtgttacccagctcctcttcatcaagaggaagc
ttagatagttctcgttctgaaaaagatagaagtttggagagagaacgcggaattggtcta
ggcaactaccatccagcaacagaaaatccaggaacttcttcaaagcgaggtttgcagatc
tccaccactgcagcccagattgccaaagtcatggaagaagtgtcagccattcatacctct
caggaagacagaagttctgggtctaccactgaattacattgtgtgacagatgagagaaat
gcacttagaagaagctctgctgcccatacacattcaaacacttacaatttcactaagtcg
gaaaattcaaataggacatgttctatgccttatgccaaattagaatacaagagatcttca
aatgatagtttaaatagtgtcagtagtagtgatggttatggtaaaagaggtcaaatgaaa
ccctcgattgaatcctattctgaagatgatgaaagtaagttttgcagttatggtcaatac
ccagccgacctagcccataaaatacatagtgcaaatcatatggatgataatgatggagaa
ctagatacaccaataaattatagtcttaaatattcagatgagcagttgaactctggaagg
caaagtccttcacagaatgaaagatgggcaagacccaaacacataatagaagatgaaata
aaacaaagtgagcaaagacaatcaaggaatcaaagtacaacttatcctgtttatactgag
agcactgatgataaacacctcaagttccaaccacattttggacagcaggaatgtgtttct
ccatacaggtcacggggagccaatggttcagaaacaaatcgagtgggttctaatcatgga
attaatcaaaatgtaagccagtctttgtgtcaagaagatgactatgaagatgataagcct
accaattatagtgaacgttactctgaagaagaacagcatgaagaagaagagagaccaaca
aattatagcataaaatataatgaagagaaacgtcatgtggatcagcctattgattatagt
ttaaaatatgccacagatattccttcatcacagaaacagtcattttcattctcaaagagt
tcatctggacaaagcagtaaaaccgaacatatgtcttcaagcagtgagaatacgtccaca
ccttcatctaatgccaagaggcagaatcagctccatccaagttctgcacagagtagaagt
ggtcagcctcaaaaggctgccacttgcaaagtttcttctattaaccaagaaacaatacag
acttattgtgtagaagatactccaatatgtttttcaagatgtagttcattatcatctttg
tcatcagctgaagatgaaataggatgtaatcagacgacacaggaagcagattctgctaat
accctgcaaatagcagaaataaaagaaaagattggaactaggtcagctgaagatcctgtg
agcgaagttccagcagtgtcacagcaccctagaaccaaatccagcagactgcagggttct
agtttatcttcagaatcagccaggcacaaagctgttgaattttcttcaggagcgaaatct
ccctccaaaagtggtgctcagacacccaaaagtccacctgaacactatgttcaggagacc
ccactcatgtttagcagatgtacttctgtcagttcacttgatagttttgagagtcgttcg
attgccagctccgttcagagtgaaccatgcagtggaatggtaagtggcattataagcccc
agtgatcttccagatagccctggacaaaccatgccaccaagcagaagtaaaacacctcca
ccacctcctcaaacagctcaaaccaagcgagaagtacctaaaaataaagcacctactgct
gaaaagagagagagtggacctaagcaagctgcagtaaatgctgcagttcagagggtccag
gttcttccagatgctgatactttattacattttgccacggaaagtactccagatggattt
tcttgttcatccagcctgagtgctctgagcctcgatgagccatttatacagaaagatgtg
gaattaagaataatgcctccagttcaggaaaatgacaatgggaatgaaacagaatcagag
cagcctaaagaatcaaatgaaaaccaagagaaagaggcagaaaaaactattgattctgaa
aaggacctattagatgattcagatgatgatgatattgaaatactagaagaatgtattatt
tctgccatgccaacaaagtcatcacgtaaagcaaaaaagccagcccagactgcttcaaaa
ttacctccacctgtggcaaggaaaccaagtcagctgcctgtgtacaaacttctaccatca
caaaacaggttgcaaccccaaaagcatgttagttttacaccgggggatgatatgccacgg
gtgtattgtgttgaagggacacctataaacttttccacagctacatctctaagtgatcta
acaatcgaatcccctccaaatgagttagctgctggagaaggagttagaggaggggcacag
tcaggtgaatttgaaaaacgagataccattcctacagaaggcagaagtacagatgaggct
caaggaggaaaaacctcatctgtaaccatacctgaattggatgacaataaagcagaggaa
ggtgatattcttgcagaatgcattaattctgctatgcccaaagggaaaagtcacaagcct
ttccgtgtgaaaaagataatggaccaggtccagcaagcatctgcgtcttcttctgcaccc
aacaaaaatcagttagatggtaagaaaaagaaaccaacttcaccagtaaaacctatacca
caaaatactgaatataggacacgtgtaagaaaaaatgcagactcaaaaaataatttaaat
gctgagagagttttctcagacaacaaagattcaaagaaacagaatttgaaaaataattcc
aaggtcttcaatgataagctcccaaataatgaagatagagtcagaggaagttttgctttt
gattcacctcatcattacacgcctattgaaggaactccttactgtttttcacgaaatgat
tctttgagttctctagattttgatgatgatgatgttgacctttccagggaaaaggctgaa
ttaagaaaggcaaaagaaaataaggaatcagaggctaaagttaccagccacacagaacta
acctccaaccaacaatcagctaataagacacaagctattgcaaagcagccaataaatcga
ggtcagcctaaacccatacttcagaaacaatccacttttccccagtcatccaaagacata
ccagacagaggggcagcaactgatgaaaagttacagaattttgctattgaaaatactccg
gtttgcttttctcataattcctctctgagttctctcagtgacattgaccaagaaaacaac
aataaagaaaatgaacctatcaaagagactgagccccctgactcacagggagaaccaagt
aaacctcaagcatcaggctatgctcctaaatcatttcatgttgaagataccccagtttgt
ttctcaagaaacagttctctcagttctcttagtattgactctgaagatgacctgttgcag
gaatgtataagctccgcaatgccaaaaaagaaaaagccttcaagactcaagggtgataat
gaaaaacatagtcccagaaatatgggtggcatattaggtgaagatctgacacttgatttg
aaagatatacagagaccagattcagaacatggtctatcccctgattcagaaaattttgat
tggaaagctattcaggaaggtgcaaattccatagtaagtagtttacatcaagctgctgct
gctgcatgtttatctagacaagcttcgtctgattcagattccatcctttccctgaaatca
ggaatctctctgggatcaccatttcatcttacacctgatcaagaagaaaaaccctttaca
agtaataaaggcccacgaattctaaaaccaggggagaaaagtacattggaaactaaaaag
atagaatctgaaagtaaaggaatcaaaggaggaaaaaaagtttataaaagtttgattact
ggaaaagttcgatctaattcagaaatttcaggccaaatgaaacagccccttcaagcaaac
atgccttcaatctctcgaggcaggacaatgattcatattccaggagttcgaaatagctcc
tcaagtacaagtcctgtttctaaaaaaggcccaccccttaagactccagcctccaaaagc
cctagtgaaggtcaaacagccaccacttctcctagaggagccaagccatctgtgaaatca
gaattaagccctgttgccaggcagacatcccaaataggtgggtcaagtaaagcaccttct
agatcaggatctagagattcgaccccttcaagacctgcccagcaaccattaagtagacct
atacagtctcctggccgaaactcaatttcccctggtagaaatggaataagtcctcctaac
aaattatctcaacttccaaggacatcatcccctagtactgcttcaactaagtcctcaggt
tctggaaaaatgtcatatacatctccaggtagacagatgagccaacagaaccttaccaaa
caaacaggtttatccaagaatgccagtagtattccaagaagtgagtctgcctccaaagga
ctaaatcagatgaataatggtaatggagccaataaaaaggtagaactttctagaatgtct
tcaactaaatcaagtggaagtgaatctgatagatcagaaagacctgtattagtacgccag
tcaactttcatcaaagaagctccaagcccaaccttaagaagaaaattggaggaatctgct
tcatttgaatctctttctccatcatctagaccagcttctcccactaggtcccaggcacaa
actccagttttaagtccttcccttcctgatatgtctctatccacacattcgtctgttcag
gctggtggatggcgaaaactcccacctaatctcagtcccactatagagtataatgatgga
agaccagcaaagcgccatgatattgcacggtctcattctgaaagtccttctagacttcca
atcaataggtcaggaacctggaaacgtgagcacagcaaacattcatcatcccttcctcga
gtaagcacttggagaagaactggaagttcatcttcaattctttctgcttcatcagaatcc
agtgaaaaagcaaaaagtgaggatgaaaaacatgtgaactctatttcaggaaccaaacaa
agtaaagaaaaccaagtatccgcaaaaggaacatggagaaaaataaaagaaaatgaattt
tctcccacaaatagtacttctcagaccgtttcctcaggtgctacaaatggtgctgaatca
aagactctaatttatcaaatggcacctgctgtttctaaaacagaggatgtttgggtgaga
attgaggactgtcccattaacaatcctagatctggaagatctcccacaggtaatactccc
ccggtgattgacagtgtttcagaaaaggcaaatccaaacattaaagattcaaaagataat
caggcaaaacaaaatgtgggtaatggcagtgttcccatgcgtaccgtgggtttggaaaat
cgcctgaactcctttattcaggtggatgcccctgaccaaaaaggaactgagataaaacca
ggacaaaataatcctgtccctgtatcagagactaatgaaagttctatagtggaacgtacc
ccattcagttctagcagctcaagcaaacacagttcacctagtgggactgttgctgccaga
gtgactccttttaattacaacccaagccctaggaaaagcagcgcagatagcacttcagct
cggccatctcagatcccaactccagtgaataacaacacaaagaagcgagattccaaaact
gacagcacagaatccagtggaacccaaagtcctaagcgccattctgggtcttaccttgtg
acatctgtttaa

Protein Sequence

>324 : length: 2843
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAM
ASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPR
RGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSL
QTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQAT
EAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA
PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLL
HGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETC
WEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQ
VDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDL
QQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAM
GSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLS
PKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGS
LDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS
QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSS
NDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE
LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTE
STDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKP
TNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS
SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQ
TYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPV
SEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQET
PLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP
PPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF
SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSE
KDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPS
QNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQ
SGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKP
FRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN
AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRND
SLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINR
GQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENN
NKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQ
ECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD
WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFT
SNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQAN
MPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKS
ELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPN
KLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG
LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESA
SFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDG
RPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSES
SEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAES
KTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN
QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERT
PFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKT
DSTESSGTQSPKRHSGSYLVTSV



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