Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

324

Name

APC

Synonymous

BTPS2|DP2|DP2.5|DP3|GS|PPP1R46;adenomatous polyposis coli;APC;adenomatous polyposis coli

Definition

adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46

Position

5q21-q22

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

apc(h) + beta-catenin(h) <==> apc(h):beta-catenin(h) (binding)
beta-catenin(h) + apc(h) + alpha-catenin1(m) <==> alpha-catenin1(m):beta-catenin(h):apc(h) (binding)
apc(h) + axin(h) + beta-catenin(h) <==> apc(h):axin(h):beta-catenin(h) (binding)
apc(h) + conductin(m) <==> apc(h):conductin(m) (binding)
apc(h) + axin(h) <==> apc(h):axin(h) (binding)
apc(h) + axin(r) + ATP --GSK3beta(r)--> apc(h){p} + axin(r) + ADP (phosphorylation; competition)
apc(h) + axin(m) + GSK3beta(h) <==> apc(h):axin(m):GSK3beta(h) (binding)
alpha-catenin1(h) + apc(h) + beta-catenin(h) + plakoglobin(h) <==> alpha-catenin1(h):apc(h):beta-catenin(h):plakoglobin(h) (binding)
apc(h) + beta-catenin(m) <==> apc(h):beta-catenin(m) (binding)
apc(h) + axin(h) + beta-catenin(h) + GSK3beta(h) <==> apc(h):axin(h):beta-catenin(h):GSK3beta(h) (binding)
apc(h) + axin(r) + beta-TrCP1(m) <==> apc(h):axin(r):beta-TrCP1(m) (binding)
apc(h) + beta-catenin(h) + beta-TrCP1(h) <==> apc(h):beta-catenin(h):beta-TrCP1(h) (binding)
apc(h) + Siah1(h) <==> apc(h):Siah1(h) (binding)
B56alpha(h) + apc(h) <==> apc(h):B56alpha(h) (binding)
B56beta(h) + apc(h) <==> apc(h):B56beta(h) (binding)
B56delta(h) + apc(h) <==> apc(h):B56delta(h) (binding)
B56gamma(h) + apc(h) <==> apc(h):B56gamma(h) (binding)
apc(h) + ATP --CKI-delta(r)--> apc(h){p} + ADP (phosphorylation)
Smad7(m.s.) + axin(m.s.) + GSK3beta(h) + beta-catenin(h) + apc(h) + CKI(h) <==> Smad7(m.s.):axin(m.s.):GSK3beta(h):beta-catenin(h):apc(h):CKI(h) (binding)
14-3-3sigma(m.s.) + apc(h) <==> 14-3-3sigma(m.s.):apc(h) (binding)
APC(h) --> apc(h) (expression).
APC(h) --> apc(h) (expression).
APC(h) --> APC(h) (expression).
hsa-miR-135a --/ APC(h) (increase of mRNA decay).
hsa-miR-135b --/ APC(h) (increase of mRNA decay).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

1038Phosphoserine (By similarity).Swiss-Prot 53.0
1180Phosphoserine (By similarity).Swiss-Prot 53.0
1371Phosphoserine (By similarity).Swiss-Prot 53.0
1697Phosphothreonine (By similarity).Swiss-Prot 53.0
1861Phosphoserine.Swiss-Prot 53.0
1863Phosphoserine.Swiss-Prot 53.0
1864Phosphoserine.Swiss-Prot 53.0
2283Phosphoserine.Swiss-Prot 53.0
2398Phosphoserine.Swiss-Prot 53.0
2674Phosphoserine (By similarity).Swiss-Prot 53.0
2710Phosphoserine (By similarity).Swiss-Prot 53.0
1279Phosphoserine (CK1 epsilon;)11487578Phospho.ELM 6.0
1392Phosphoserine (CK1 epsilon;)11487578Phospho.ELM 6.0
1861Phosphoserine17081983Phospho.ELM 6.0
1863Phosphoserine17081983Phospho.ELM 6.0
1864Phosphoserine17081983Phospho.ELM 6.0
2398Phosphoserine17081983Phospho.ELM 6.0
2034Phosphoserine11689703Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr5

 Promoter: 112099983 - 112101983GoldenGate_Methylation_Cancer_Panel_I

chr5

 Promoter: 112099983 - 112101983GSE27584

chr5

 Promoter: 112099983 - 112101983Agilent_014791_44K

chr5

 Promoter: 112099983 - 112101983PMID:20563638

chr5

 Promoter: 112099983 - 112101983PMID:15526363

chr5

 Promoter: 112099983 - 112101983PMID:15326380

chr5

 Promoter: 112099983 - 112101983PMID:16207479

chr5

 Promoter: 112099983 - 112101983PMID:15386372

chr5

 Promoter: 112099983 - 112101983PMID:15375009

chr5

 Promoter: 112099983 - 112101983PMID:15760919

chr5

 Promoter: 112099983 - 112101983PMID:15122305

chr5

 Promoter: 112099983 - 112101983PMID:15389252

chr5

 Promoter: 112099983 - 112101983PMID:12970888

chr5

 Promoter: 112099983 - 112101983PMID:14719065

chr5

 Promoter: 112099983 - 112101983PMID:15087381

chr5

 Promoter: 112099983 - 112101983PMID:16902913

chr5

 Promoter: 112099983 - 112101983PMID:17378912

chr5

 Promoter: 112099983 - 112101983PMID:16336454

chr5

 Promoter: 112099983 - 112101983PMID:15476557

chr5

 Promoter: 112099983 - 112101983PMID:16598760

chr5

 Promoter: 112099983 - 112101983PMID:16870044

chr5

 Promoter: 112099983 - 112101983PMID:12841866

chr5

 Promoter: 112099983 - 112101983PMID:11448917

chr5

 Promoter: 112099983 - 112101983PMID:15042681

chr5

 Promoter: 112099983 - 112101983PMID:12684406

chr5

 Promoter: 112099983 - 112101983PMID:16043258

chr5

 Promoter: 112099983 - 112101983PMID:16644104

chr5

 Promoter: 112099983 - 112101983PMID:12467239

chr5

 Promoter: 112099983 - 112101983PMID:11429699

chr5

 Promoter: 112099983 - 112101983PMID:11895880

chr5

 Promoter: 112099983 - 112101983PMID:16452191

chr5

 Promoter: 112099983 - 112101983PMID:15639718

chr5

 Promoter: 112099983 - 112101983PMID:15073103

chr5

 Promoter: 112099983 - 112101983PMID:15758578

chr5

 Promoter: 112099983 - 112101983PMID:16075282

chr5

 Promoter: 112099983 - 112101983PMID:10951570

chr5

 Promoter: 112099983 - 112101983PMID:17369979

chr5

 Promoter: 112099983 - 112101983PMID:16163424

chr5

 Promoter: 112099983 - 112101983PMID:16619216

chr5

 Promoter: 112099983 - 112101983PMID:15197775

chr5

 Promoter: 112099983 - 112101983PMID:15942635

chr5

 Promoter: 112099983 - 112101983PMID:12695555

chr5

 Promoter: 112099983 - 112101983PMID:12746473

chr5

 Promoter: 112099983 - 112101983PMID:14675710

chr5

 Promoter: 112099983 - 112101983PMID:16956712

chr5

 Promoter: 112099983 - 112101983PMID:15026333

chr5

 Promoter: 112099983 - 112101983PMID:14743506

chr5

 Promoter: 112099983 - 112101983PMID:15623627

chr5

 Promoter: 112099983 - 112101983PMID:15292941

chr5

 Promoter: 112099983 - 112101983PMID:11839671

chr5

 Promoter: 112099983 - 112101983PMID:15930345

chr5

 Promoter: 112099983 - 112101983PMID:17070312

chr5

 Promoter: 112099983 - 112101983PMID:16170165

chr5

 Promoter: 112099983 - 112101983PMID:17363525

chr5

 Promoter: 112099983 - 112101983PMID:17139617

chr5

 Promoter: 112099983 - 112101983PMID:16446401

chr5

 Promoter: 112099983 - 112101983PMID:15448006

chr5

 Promoter: 112099983 - 112101983PMID:17222366

chr5

 Promoter: 112099983 - 112101983PMID:15788661

chr5

 Promoter: 112099983 - 112101983PMID:15508191

chr5

 Promoter: 112099983 - 112101983PMID:15328171

chr5

 Promoter: 112099983 - 112101983PMID:15671542

chr5

 Promoter: 112099983 - 112101983PMID:15172987

chr5

 Promoter: 112099983 - 112101983PMID:11437404

chr5

 Promoter: 112099983 - 112101983PMID:15543763

chr5

 Promoter: 112099983 - 112101983PMID:12800196

chr5

 Promoter: 112099983 - 112101983PMID:12937151

chr5

 Promoter: 112099983 - 112101983PMID:15897561

chr5

 Promoter: 112099983 - 112101983PMID:14507645

chr5

 Promoter: 112099983 - 112101983PMID:16565510

chr5

 Promoter: 112099983 - 112101983PMID:15467712

chr5

 Promoter: 112099983 - 112101983PMID:12213730

chr5

 Promoter: 112099983 - 112101983PMID:16331610

chr5

 Promoter: 112099983 - 112101983PMID:11448914

chr5

 Promoter: 112099983 - 112101983PMID:15589597

chr5

 Promoter: 112099983 - 112101983PMID:15713962

chr5

 Promoter: 112099983 - 112101983PMID:12773202

chr5

 Promoter: 112099983 - 112101983PMID:15217927

chr5

 Promoter: 112099983 - 112101983PMID:15289362

chr5

 Promoter: 112099983 - 112101983PMID:16278815

chr5

 Promoter: 112099983 - 112101983PMID:16407829

chr5

 Promoter: 112099983 - 112101983PMID:11078757

chr5

 Promoter: 112099983 - 112101983PMID:15041703

chr5

 Promoter: 112099983 - 112101983PMID:17017434

chr5

 Promoter: 112099983 - 112101983PMID:16849682

chr5

 Promoter: 112099983 - 112101983PMID:15154012

chr5

 Promoter: 112099983 - 112101983PMID:16775427

chr5

 Promoter: 112099983 - 112101983PMID:17177027

chr5

 Promoter: 112099983 - 112101983PMID:16061849

chr5

 Promoter: 112099983 - 112101983PMID:12429618

chr5

 Promoter: 112099983 - 112101983PMID:16537562

chr5

 Promoter: 112099983 - 112101983PMID:12584167

chr5

 Promoter: 112099983 - 112101983PMID:14501508

chr5

 Promoter: 112099983 - 112101983PMID:15447999

chr5

 Promoter: 112099983 - 112101983PMID:16699861

chr5

 Promoter: 112099983 - 112101983PMID:14527906

chr5

 Promoter: 112099983 - 112101983PMID:16166431

chr5

 Promoter: 112099983 - 112101983PMID:16928264

chr5

 Promoter: 112099983 - 112101983PMID:12097272

chr5

 Promoter: 112099983 - 112101983PMID:15361208

chr5

 Promoter: 112099983 - 112101983PMID:15153437

chr5

 Promoter: 112099983 - 112101983PMID:16858687

chr5

 Promoter: 112099983 - 112101983PMID:12082624

chr5

 Promoter: 112099983 - 112101983PMID:15133491

chr5

 Promoter: 112099983 - 112101983PMID:15641992

chr5

 Promoter: 112099983 - 112101983PMID:16785414

chr5

 Promoter: 112099983 - 112101983PMID:12545168

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