Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

324

Name

APC

Synonymous

BTPS2|DP2|DP2.5|DP3|GS|PPP1R46;adenomatous polyposis coli;APC;adenomatous polyposis coli

Definition

adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46

Position

5q21-q22

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ARHGEF4NCI_NATURE;

in same component

 AXIN1CELL_MAP;

in same component

 AXIN1NCI_NATURE;

in same component

 AXIN2NCI_NATURE;

in same component

 CTBP1NCI_NATURE;

in same component

 CTNNB1CELL_MAP;

in same component

 CTNNB1NCI_NATURE;

in same component

 DLG1NCI_NATURE;

in same component

 GSK3BCELL_MAP;

in same component

 SPATA13NCI_NATURE;

interacts with

 ACTN1BIOGRID;

interacts with

 ACTN1INTACT;

interacts with

 AGFG1BIOGRID;

interacts with

 AGFG1INTACT;

interacts with

 ANKRD17BIOGRID;

interacts with

 ANKRD17INTACT;

interacts with

 ANXA7BIOGRID;

interacts with

 ANXA7INTACT;

interacts with

 AP2B1BIOGRID;

interacts with

 AP2B1INTACT;

interacts with

 ARHGEF4BIOGRID;

interacts with

 ARHGEF4HPRD;

interacts with

 Axin1BIOGRID;

interacts with

 AXIN1BIOGRID;

interacts with

 AXIN1CELL_MAP;

interacts with

 AXIN1HPRD;

interacts with

 AXIN1MINT;

interacts with

 AXIN2BIOGRID;

interacts with

 Axin2CELL_MAP;

interacts with

 AXIN2HPRD;

interacts with

 BTRCBIOGRID;

interacts with

 BtrcCELL_MAP;

interacts with

 BUB1BIOGRID;

interacts with

 BUB1HPRD;

interacts with

 BUB1BBIOGRID;

interacts with

 BUB1BHPRD;

interacts with

 BUB3BIOGRID;

interacts with

 BUB3HPRD;

interacts with

 C4ABIOGRID;

interacts with

 C4AINTACT;

interacts with

 CDH1HPRD;

interacts with

 CGNL1BIOGRID;

interacts with

 CGNL1INTACT;

interacts with

 COG4BIOGRID;

interacts with

 COG4INTACT;

interacts with

 COG5BIOGRID;

interacts with

 COG5INTACT;

interacts with

 CREBBPBIOGRID;

interacts with

 CREBBPINTACT;

interacts with

 CSNK1A1BIOGRID;

interacts with

 CSNK1EHPRD;

interacts with

 CSNK2A1BIOGRID;

interacts with

 CSNK2BBIOGRID;

interacts with

 CTBP1BIOGRID;

interacts with

 CTBP1HPRD;

interacts with

 CTNNA1BIOGRID;

interacts with

 CTNNA1INTACT;

interacts with

 CTNNB1BIOGRID;

interacts with

 CTNNB1CELL_MAP;

interacts with

 CTNNB1HPRD;

interacts with

 CTNNB1MINT;

interacts with

 CTNNBIP1HPRD;

interacts with

 CYTH2BIOGRID;

interacts with

 CYTH2INTACT;

interacts with

 DLG3BIOGRID;

interacts with

 DLG4CELL_MAP;

interacts with

 DLG4HPRD;

interacts with

 Dlg4MINT;

interacts with

 DLGAP1BIOGRID;

interacts with

 DLGAP1HPRD;

interacts with

 DSTBIOGRID;

interacts with

 DSTINTACT;

interacts with

 DVL1MINT;

interacts with

 DVL1L1MINT;

interacts with

 Dvl2MINT;

interacts with

 DVL2MINT;

interacts with

 EPAS1BIOGRID;

interacts with

 EPAS1INTACT;

interacts with

 ERBB2IPBIOGRID;

interacts with

 ERBB2IPINTACT;

interacts with

 EXPH5INTACT;

interacts with

 FBXO30BIOGRID;

interacts with

 FBXO30INTACT;

interacts with

 FHOD1BIOGRID;

interacts with

 FHOD1INTACT;

interacts with

 FLNABIOGRID;

interacts with

 FLNAINTACT;

interacts with

 Fzd2CELL_MAP;

interacts with

 GIGYF2BIOGRID;

interacts with

 GIGYF2INTACT;

interacts with

 GLIS2HPRD;

interacts with

 GOLGA2BIOGRID;

interacts with

 GOLGA2INTACT;

interacts with

 GRIN2BHPRD;

interacts with

 GSK3BBIOGRID;

interacts with

 GSK3BCELL_MAP;

interacts with

 GSK3BHPRD;

interacts with

 HGSBIOGRID;

interacts with

 HGSINTACT;

interacts with

 HNF4AHPRD;

interacts with

 HNRNPMBIOGRID;

interacts with

 HSPA5BIOGRID;

interacts with

 HSPA5INTACT;

interacts with

 ING5BIOGRID;

interacts with

 ING5INTACT;

interacts with

 IQGAP1HPRD;

interacts with

 JUPBIOGRID;

interacts with

 JUPCELL_MAP;

interacts with

 JUPHPRD;

interacts with

 JUPINTACT;

interacts with

 KIAA1328BIOGRID;

interacts with

 KIAA1328INTACT;

interacts with

 KIAA1370BIOGRID;

interacts with

 KIAA1370INTACT;

interacts with

 KIF3BHPRD;

interacts with

 KIF5BBIOGRID;

interacts with

 KIF5BINTACT;

interacts with

 KIFAP3BIOGRID;

interacts with

 KIFAP3HPRD;

interacts with

 KRT13BIOGRID;

interacts with

 KRT13INTACT;

interacts with

 KRT14BIOGRID;

interacts with

 KRT14INTACT;

interacts with

 KRT15BIOGRID;

interacts with

 KRT15INTACT;

interacts with

 KRT17BIOGRID;

interacts with

 KRT17INTACT;

interacts with

 KRT19BIOGRID;

interacts with

 KRT19INTACT;

interacts with

 KRT23BIOGRID;

interacts with

 KRT23INTACT;

interacts with

 KRT5BIOGRID;

interacts with

 KRT5INTACT;

interacts with

 LAMA3BIOGRID;

interacts with

 LAMA3INTACT;

interacts with

 LAMA4BIOGRID;

interacts with

 LAMA4INTACT;

interacts with

 LPHN1BIOGRID;

interacts with

 LPHN1INTACT;

interacts with

 MACF1BIOGRID;

interacts with

 MACF1INTACT;

interacts with

 MAD2L1BIOGRID;

interacts with

 MAPRE1BIOGRID;

interacts with

 MAPRE1HPRD;

interacts with

 MAPRE2BIOGRID;

interacts with

 MBD5BIOGRID;

interacts with

 MBD5INTACT;

interacts with

 MCM3APBIOGRID;

interacts with

 MCM3APINTACT;

interacts with

 MT-ND4BIOGRID;

interacts with

 MUC1BIOGRID;

interacts with

 MYCMINT;

interacts with

 MYH10BIOGRID;

interacts with

 MYH10INTACT;

interacts with

 MYH11BIOGRID;

interacts with

 MYH11INTACT;

interacts with

 MYO6BIOGRID;

interacts with

 MYO6INTACT;

interacts with

 NAV1BIOGRID;

interacts with

 NAV1INTACT;

interacts with

 NAV2BIOGRID;

interacts with

 NAV2INTACT;

interacts with

 NAV3BIOGRID;

interacts with

 NAV3INTACT;

interacts with

 NCKAP5BIOGRID;

interacts with

 NCKAP5INTACT;

interacts with

 NCKAP5LBIOGRID;

interacts with

 NCKAP5LINTACT;

interacts with

 NEBBIOGRID;

interacts with

 NEBINTACT;

interacts with

 NOSTRINBIOGRID;

interacts with

 NOSTRININTACT;

interacts with

 NUP153BIOGRID;

interacts with

 NUP153INTACT;

interacts with

 NUP214BIOGRID;

interacts with

 NUP214INTACT;

interacts with

 NUP54BIOGRID;

interacts with

 NUP54INTACT;

interacts with

 NUP98BIOGRID;

interacts with

 NUP98INTACT;

interacts with

 NUPL1BIOGRID;

interacts with

 NUPL1INTACT;

interacts with

 NUPL2BIOGRID;

interacts with

 NUPL2INTACT;

interacts with

 PNISRBIOGRID;

interacts with

 PNISRINTACT;

interacts with

 POM121CBIOGRID;

interacts with

 POM121CINTACT;

interacts with

 PPP1R13BBIOGRID;

interacts with

 PPP1R13BINTACT;

interacts with

 PPP2CAHPRD;

interacts with

 PPP2R5ABIOGRID;

interacts with

 PPP2R5AHPRD;

interacts with

 PRKACAHPRD;

interacts with

 PSMD1BIOGRID;

interacts with

 PSMD1INTACT;

interacts with

 PTK2MINT;

interacts with

 PTPN13HPRD;

interacts with

 PxnMINT;

interacts with

 PXNMINT;

interacts with

 RANBP2BIOGRID;

interacts with

 RANBP2INTACT;

interacts with

 RANBP9BIOGRID;

interacts with

 RANBP9INTACT;

interacts with

 RBM4BBIOGRID;

interacts with

 RBM4BINTACT;

interacts with

 RP1HPRD;

interacts with

 RPS27BIOGRID;

interacts with

 RPS27INTACT;

interacts with

 SCRIBMINT;

interacts with

 SEC31ABIOGRID;

interacts with

 SEC31AINTACT;

interacts with

 SETDB1BIOGRID;

interacts with

 SETDB1INTACT;

interacts with

 SFNBIOGRID;

interacts with

 SFNMINT;

interacts with

 SIAH1BIOGRID;

interacts with

 SIAH1HPRD;

interacts with

 SMC3BIOGRID;

interacts with

 SMC3INTACT;

interacts with

 SNRNP200BIOGRID;

interacts with

 SPECC1LBIOGRID;

interacts with

 SPECC1LINTACT;

interacts with

 SPTBN1BIOGRID;

interacts with

 SPTBN1INTACT;

interacts with

 SPTBN2BIOGRID;

interacts with

 SPTBN2INTACT;

interacts with

 SYNE1BIOGRID;

interacts with

 SYNE1INTACT;

interacts with

 TAF1BIOGRID;

interacts with

 TAF1INTACT;

interacts with

 TFAP2ABIOGRID;

interacts with

 TFAP2ACELL_MAP;

interacts with

 TFAP2AHPRD;

interacts with

 TPRBIOGRID;

interacts with

 TPRINTACT;

interacts with

 TRIM21BIOGRID;

interacts with

 TRIM21INTACT;

interacts with

 TUBA4ABIOGRID;

interacts with

 TUBA4AHPRD;

interacts with

 XPO1BIOGRID;

interacts with

 YWHAZMINT;

interacts with

 ZFP106BIOGRID;

interacts with

 ZFP106INTACT;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 SP1NCI_NATURE;

metabolic catalysis

 TP53NCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 APCNCI_NATURE;

reacts with

 ARHGEF4NCI_NATURE;

reacts with

 AXIN1NCI_NATURE;

reacts with

 AXIN2NCI_NATURE;

reacts with

 CTBP1NCI_NATURE;

reacts with

 CTNNB1NCI_NATURE;

reacts with

 DLG1NCI_NATURE;

reacts with

 FZD5NCI_NATURE;

reacts with

 LRP6NCI_NATURE;

reacts with

 WNT3ANCI_NATURE;

state change

 AXIN1NCI_NATURE;

state change

 BTRCNCI_NATURE;

state change

 Csnk1eCELL_MAP;

state change

 CUL1NCI_NATURE;

state change

 DVL1NCI_NATURE;

state change

 FRAT1NCI_NATURE;

state change

 FZD5NCI_NATURE;

state change

 Gsk3bCELL_MAP;

state change

 GSK3BCELL_MAP;

state change

 GSK3BNCI_NATURE;

state change

 LRP6NCI_NATURE;

state change

 NOTCH1NCI_NATURE;

state change

 PPP2CACELL_MAP;

state change

 PPP2R5ANCI_NATURE;

state change

 PPP2R5DNCI_NATURE;

state change

 SKP1NCI_NATURE;

state change

 WNT3ANCI_NATURE;

state change

 XPO1NCI_NATURE;

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