| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3486 |
Name | IGFBP3 |
Synonym | BP-53|IBP3;insulin-like growth factor binding protein 3;IGFBP3;insulin-like growth factor binding protein 3 |
Definition | IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3 |
Position | 7p12.3 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 8805 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs);PID Reactome;500133 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Disease | overall effect;GAD |
Disease | Cancer;FunDO |
Disease | Skin disease, Genetic;FunDO |
Disease | Sickle cell disease;FunDO |
Disease | Liver disease;FunDO |
Disease | METABOLIC;GAD |
Disease | Stroke;FunDO |
Disease | Cirrhosis;FunDO |
Disease | colorectal cancer;GAD |
Disease | Hamman-Rich syndrome;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Gestational diabetes;FunDO |
Disease | Hypothyroidism;FunDO |
Disease | Growth Disorders;GAD |
Disease | CANCER;GAD |
Disease | Endometriosis;FunDO |
Disease | Cerebral palsy;FunDO |
Disease | Growth retardation;FunDO |
Disease | breast cancer;GAD |
Disease | Fibromyalgia;FunDO |
Disease | Obesity;FunDO |
Disease | insulin-like growth factor;GAD |
Disease | Atherosclerosis;FunDO |
Disease | Acromegaly;FunDO |
Disease | Metabolic syndrome X;FunDO |
|
External Links |
|
Links to Entrez Gene | 3486 |
Links to all GeneRIF Items | 3486 |
Links to iHOP | 3486 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>3486 : length: 876 atgcagcgggcgcgacccacgctctgggccgctgcgctgactctgctggtgctgctccgc gggccgccggtggcgcgggctggcgcgagctcggcgggcttgggtcccgtggtgcgctgc gagccgtgcgacgcgcgtgcactggcccagtgcgcgcctccgcccgccgtgtgcgcggag ctggtgcgcgagccgggctgcggctgctgcctgacgtgcgcactgagcgagggccagccg tgcggcatctacaccgagcgctgtggctccggccttcgctgccagccgtcgcccgacgag gcgcgaccgctgcaggcgctgctggacggccgcgggctctgcgtcaacgctagtgccgtc agccgcctgcgcgcctacctgctgccagcgccgccagctccaggaaatgctagtgagtcg gaggaagaccgcagcgccggcagtgtggagagcccgtccgtctccagcacgcaccgggtg tctgatcccaagttccaccccctccattcaaagataatcatcatcaagaaagggcatgct aaagacagccagcgctacaaagttgactacgagtctcagagcacagatacccagaacttc tcctccgagtccaagcgggagacagaatatggtccctgccgtagagaaatggaagacaca ctgaatcacctgaagttcctcaatgtgctgagtcccaggggtgtacacattcccaactgt gacaagaagggattttataagaaaaagcagtgtcgcccttccaaaggcaggaagcggggc ttctgctggtgtgtggataagtatgggcagcctctcccaggctacaccaccaaggggaag gaggacgtgcactgctacagcatgcagagcaagtag |
Protein Sequence |
>3486 : length: 291 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK |