Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3486

Name

IGFBP3

Synonymous

BP-53|IBP3;insulin-like growth factor binding protein 3;IGFBP3;insulin-like growth factor binding protein 3

Definition

IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3

Position

7p12.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding)
IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding)
IGFBP-3(h) + VDR(h) <==> IGFBP-3(h):VDR(h) (binding)
IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p14(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p24(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p20(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p18(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p24(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p22(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p20(h) + protein remnants (cleavage)
IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p14(h) + protein remnants (cleavage)
TSP-1(h) + IGFBP-3(h) <==> TSP-1(h):IGFBP-3(h) (binding)
OPN(h) + IGFBP-3(h) <==> OPN(h):IGFBP-3(h) (binding)
IGFBP-3(h) + ADAM12-isoform2(h) <==> IGFBP-3(h):ADAM12-isoform2(h) (binding)
IGFBP-3(h) --ADAM12-isoform2(h)--> IGFBP3-p20(h) + protein remnants (cleavage)
IGFBP-3(h) --ADAM12-isoform2(h)--> IGFBP3-p10(h) + protein remnants (cleavage)
IGFBP3(h) --> IGFBP-3(h) (expression).
IGFBP-3(h) --> Bcl-2(h){pS} (increase of phosphorylation)
RXR-alpha(h) + IGFBP-3(h) <==> RXR-alpha(h):IGFBP-3(h) (binding)
RXR-alpha(m.s.) + IGFBP-3(h) <==> RXR-alpha(m.s.):IGFBP-3(h) (binding)
IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding)
IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding)
IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding)
ALS(h) + IGF-2(h) + IGFBP-3(h) <==> ALS(h):IGF-2(h):IGFBP-3(h) (binding)
ALS(h) + IGF-2(h) + IGFBP-3(h) <==> ALS(h):IGF-2(h):IGFBP-3(h) (binding)
IGFBP3(h) --> IGFBP-3(h) (expression).
TNF-alpha(v.s.) --> IGFBP-3(h) (increase of abundance)
5alphaDHT --/ IGFBP-3(h) (decrease of abundance)
testosterone --/ IGFBP-3(h) (decrease of abundance)
dehydroepiandrosterone --/ IGFBP-3(h) (decrease of abundance)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

116N-linked (GlcNAc...).Swiss-Prot 53.0
136N-linked (GlcNAc...).Swiss-Prot 53.0
199N-linked (GlcNAc...).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr7

Promoter: 45926896 - 45928896Agilent_014791

chr7

Promoter: 45926896 - 45928896GoldenGate_Methylation_Cancer_Panel_I

chr7

Promoter: 45926896 - 45928896GoldenGate_Methylation_Cancer_Panel_I

chr7

Promoter: 45926896 - 45928896GSE27584

chr7

Promoter: 45926896 - 45928896GSE27584

chr7

Promoter: 45926896 - 45928896Agilent_014791_44K

chr7

Promoter: 45926896 - 45928896Agilent_014791

chr7

Promoter: 45926896 - 45928896PMID:16707423

chr7

Promoter: 45926896 - 45928896PMID:16707423

chr7

Promoter: 45926896 - 45928896PMID:16773633

chr7

Promoter: 45926896 - 45928896PMID:16773633

chr7

Promoter: 45926896 - 45928896PMID:16445635

chr7

Promoter: 45926896 - 45928896PMID:16445635

chr7

Promoter: 45926896 - 45928896PMID:15247904

chr7

Promoter: 45926896 - 45928896PMID:15247904

chr7

Promoter: 45926896 - 45928896PMID:12473575

chr7

Promoter: 45926896 - 45928896PMID:12473575

chr7

Promoter: 45926896 - 45928896PMID:17096329

chr7

Promoter: 45926896 - 45928896PMID:17096329

chr7

Promoter: 45926896 - 45928896PMID:17372756

chr7

Promoter: 45926896 - 45928896PMID:17372756

chr7

Promoter: 45926896 - 45928896PMID:16367923

chr7

Promoter: 45926896 - 45928896PMID:16367923

chr7

Promoter: 45926896 - 45928896PMID:16642478

chr7

Promoter: 45926896 - 45928896PMID:16642478


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