| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 3486 |
Name | IGFBP3 |
Synonymous | BP-53|IBP3;insulin-like growth factor binding protein 3;IGFBP3;insulin-like growth factor binding protein 3 |
Definition | IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3 |
Position | 7p12.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding) | IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding) | IGFBP-3(h) + VDR(h) <==> IGFBP-3(h):VDR(h) (binding) | IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p14(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p24(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p20(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-2(h)--> IGFBP3-p18(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p24(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p22(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p20(h) + protein remnants (cleavage) | IGFBP-3(h) --kallikrein-3(h)--> IGFBP3-p14(h) + protein remnants (cleavage) | TSP-1(h) + IGFBP-3(h) <==> TSP-1(h):IGFBP-3(h) (binding) | OPN(h) + IGFBP-3(h) <==> OPN(h):IGFBP-3(h) (binding) | IGFBP-3(h) + ADAM12-isoform2(h) <==> IGFBP-3(h):ADAM12-isoform2(h) (binding) | IGFBP-3(h) --ADAM12-isoform2(h)--> IGFBP3-p20(h) + protein remnants (cleavage) | IGFBP-3(h) --ADAM12-isoform2(h)--> IGFBP3-p10(h) + protein remnants (cleavage) | IGFBP3(h) --> IGFBP-3(h) (expression). | IGFBP-3(h) --> Bcl-2(h){pS} (increase of phosphorylation) | RXR-alpha(h) + IGFBP-3(h) <==> RXR-alpha(h):IGFBP-3(h) (binding) | RXR-alpha(m.s.) + IGFBP-3(h) <==> RXR-alpha(m.s.):IGFBP-3(h) (binding) | IGF-1(h) + IGFBP-3(h) <==> IGF-1(h):IGFBP-3(h) (binding) | IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding) | IGF-2(h) + IGFBP-3(h) <==> IGF-2(h):IGFBP-3(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-3(h) <==> ALS(h):IGF-2(h):IGFBP-3(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-3(h) <==> ALS(h):IGF-2(h):IGFBP-3(h) (binding) | IGFBP3(h) --> IGFBP-3(h) (expression). | TNF-alpha(v.s.) --> IGFBP-3(h) (increase of abundance) | 5alphaDHT --/ IGFBP-3(h) (decrease of abundance) | testosterone --/ IGFBP-3(h) (decrease of abundance) | dehydroepiandrosterone --/ IGFBP-3(h) (decrease of abundance) |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
116 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 136 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 199 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 45926896 - 45928896 | Agilent_014791 |
chr7 |
Promoter: 45926896 - 45928896 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 45926896 - 45928896 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 45926896 - 45928896 | GSE27584 |
chr7 |
Promoter: 45926896 - 45928896 | GSE27584 |
chr7 |
Promoter: 45926896 - 45928896 | Agilent_014791_44K |
chr7 |
Promoter: 45926896 - 45928896 | Agilent_014791 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16707423 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16707423 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16773633 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16773633 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16445635 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16445635 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:15247904 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:15247904 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:12473575 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:12473575 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:17096329 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:17096329 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:17372756 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:17372756 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16367923 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16367923 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16642478 |
chr7 |
Promoter: 45926896 - 45928896 | PMID:16642478 |