| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5347 |
Name | PLK1 |
Synonym | PLK|STPK13;polo-like kinase 1;PLK1;polo-like kinase 1 |
Definition | PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1 |
Position | 16p12.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 961 |
TUSON P-value | 0.04045264 |
|
Pathways and Diseases |
|
Pathway | Centrosome maturation;PID Reactome;500380 |
Pathway | Golgi Cisternae Pericentriolar Stack Reorganization;PID Reactome;500931 |
Pathway | Mitotic Prometaphase;PID Reactome;500976 |
Pathway | Recruitment of mitotic centrosome proteins and complexes;PID Reactome;500381 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Polo-like kinase signaling events in the cell cycle;PID Curated;200176 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Loss of Nlp from mitotic centrosomes;PID Reactome;500384 |
Pathway | Mitotic Telophase /Cytokinesis;PID Reactome;501001 |
Pathway | Phosphorylation of Emi1;PID Reactome;500392 |
Pathway | Loss of proteins required for interphase microtubule organization from the centrosome;PID Reactome;500383 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | DNA Replication;Reactome;REACT:383 |
Pathway | Mitotic Metaphase/Anaphase Transition;PID Reactome;500868 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | Phosphorylation of the APC/C;PID Reactome;500395 |
Pathway | M Phase;PID Reactome;500909 |
Pathway | PLK1 signaling events;PID Curated;200087 |
Pathway | Polo-like kinase mediated events;PID Reactome;500379 |
Disease | Cancer;FunDO |
Disease | Rheumatoid arthritis;FunDO |
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External Links |
|
Links to Entrez Gene | 5347 |
Links to all GeneRIF Items | 5347 |
Links to iHOP | 5347 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5347 : length: 1812 atgagtgctgcagtgactgcagggaagctggcacgggcaccggccgaccctgggaaagcc ggggtccccggagttgcagctcccggagctccggcggcggctccaccggcgaaagagatc ccggaggtcctagtggacccacgcagccggcggcgctatgtgcggggccgctttttgggc aagggcggctttgccaagtgcttcgagatctcggacgcggacaccaaggaggtgttcgcg ggcaagattgtgcctaagtctctgctgctcaagccgcaccagagggagaagatgtccatg gaaatatccattcaccgcagcctcgcccaccagcacgtcgtaggattccacggctttttc gaggacaacgacttcgtgttcgtggtgttggagctctgccgccggaggtctctcctggag ctgcacaagaggaggaaagccctgactgagcctgaggcccgatactacctacggcaaatt gtgcttggctgccagtacctgcaccgaaaccgagttattcatcgagacctcaagctgggc aaccttttcctgaatgaagatctggaggtgaaaataggggattttggactggcaaccaaa gtcgaatatgacggggagaggaagaagaccctgtgtgggactcctaattacatagctccc gaggtgctgagcaagaaagggcacagtttcgaggtggatgtgtggtccattgggtgtatc atgtataccttgttagtgggcaaaccaccttttgagacttcttgcctaaaagagacctac ctccggatcaagaagaatgaatacagtattcccaagcacatcaaccccgtggccgcctcc ctcatccagaagatgcttcagacagatcccactgcccgcccaaccattaacgagctgctt aatgacgagttctttacttctggctatatccctgcccgtctccccatcacctgcctgacc attccaccaaggttttcgattgctcccagcagcctggaccccagcaaccggaagcccctc acagtcctcaataaaggcttggagaaccccctgcctgagcgtccccgggaaaaagaagaa ccagtggttcgagagacaggtgaggtggtcgactgccacctcagtgacatgctgcagcag ctgcacagtgtcaatgcctccaagccctcggagcgtgggctggtcaggcaagaggaggct gaggatcctgcctgcatccccatcttctgggtcagcaagtgggtggactattcggacaag tacggccttgggtatcagctctgtgataacagcgtgggggtgctcttcaatgactcaaca cgcctcatcctctacaatgatggtgacagcctgcagtacatagagcgtgacggcactgag tcctacctcaccgtgagttcccatcccaactccttgatgaagaagatcaccctccttaaa tatttccgcaattacatgagcgagcacttgctgaaggcaggtgccaacatcacgccgcgc gaaggtgatgagctcgcccggctgccctacctacggacctggttccgcacccgcagcgcc atcatcctgcacctcagcaacggcagcgtgcagatcaacttcttccaggatcacaccaag ctcatcttgtgcccactgatggcagccgtgacctacatcgacgagaagcgggacttccgc acataccgcctgagtctcctggaggagtacggctgctgcaaggagctggccagccggctc cgctacgcccgcactatggtggacaagctgctgagctcacgctcggccagcaaccgtctc aaggcctcctaa |
Protein Sequence |
>5347 : length: 603 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL KAS |