Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5347

Name

PLK1

Synonymous

polo-like kinase 1;PLK1;polo-like kinase 1

Definition

PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1

Position

16p12.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.14.

The copy number variations for various cancers

Top

There is no record for PLK1

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.938G>A; p.R313H; 16:23683991-23683991

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1586G>A; p.S529N; 16:23689654-23689654

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.938G>A; p.R313H; 16:23683991-23683991

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.556G>T; p.E186*; 16:23680231-23680231

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1792A>T; p.N598Y; 16:23690043-23690043

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1687C>T; p.R563C; 16:23689938-23689938

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1070delA; p.E359fs*96; 16:23687502-23687502

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.878G>A; p.R293H; 16:23683931-23683931

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.913T>A; p.F305I; 16:23683966-23683966

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.913T>A; p.F305I; 16:23683966-23683966

 stomachadenocarcinomaSubstitution - Missense

c.749C>A; p.P250H; 16:23682090-23682090

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1748C>T; p.A583V; 16:23689999-23689999

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1499G>A; p.R500H; 16:23689567-23689567

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1499G>A; p.R500H; 16:23689567-23689567

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.146G>A; p.S49N; 16:23679078-23679078

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.418G>C; p.E140Q; 16:23680093-23680093

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.418G>C; p.E140Q; 16:23680093-23680093

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1773G>A; p.L591L; 16:23690024-23690024

 breastcarcinomaSubstitution - coding silent

c.1446C>T; p.F482F; 16:23689514-23689514

 skinmalignant_melanomaSubstitution - coding silent

c.906C>T; p.D302D; 16:23683959-23683959

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.732G>C; p.L244F; 16:23682073-23682073

 breastcarcinomaSubstitution - Missense

c.968C>T; p.P323L; 16:23684021-23684021

 skinmalignant_melanomaSubstitution - Missense

c.664G>T; p.V222L; 16:23681000-23681000

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Missense

c.937C>A; p.R313S; 16:23683990-23683990

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1041G>C; p.L347F; 16:23687473-23687473

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.506G>A; p.R169Q; 16:23680181-23680181

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.614G>T; p.G205V; 16:23680950-23680950

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.1100G>T; p.G367V; 16:23687532-23687532

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1605delC; p.Q536fs*11; 16:23689673-23689673

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.169C>A; p.R57S; 16:23679101-23679101

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1022C>T; p.T341I; 16:23684075-23684075

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.143G>A; p.R48H; 16:23679075-23679075

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.785G>A; p.R262Q; 16:23682126-23682126

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.977C>T; p.S326L; 16:23684030-23684030

 skinmalignant_melanomaSubstitution - Missense

c.977C>T; p.S326L; 16:23684030-23684030

 skinmalignant_melanomaSubstitution - Missense

c.977C>T; p.S326L; 16:23684030-23684030

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.47A>G; p.D16G; 16:23678979-23678979

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.690C>T; p.F230F; 16:23681026-23681026

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.690C>T; p.F230F; 16:23681026-23681026

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.690C>T; p.F230F; 16:23681026-23681026

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1264G>C; p.G422R; 16:23688739-23688739

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1567C>T; p.L523L; 16:23689635-23689635

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.690C>A; p.F230L; 16:23681026-23681026

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.690C>A; p.F230L; 16:23681026-23681026

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.452C>T; p.P151L; 16:23680127-23680127

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.892G>A; p.E298K; 16:23683945-23683945

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.660C>T; p.P220P; 16:23680996-23680996

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1751G>A; p.R584H; 16:23690002-23690002

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.375C>G; p.F125L; 16:23679307-23679307

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.531C>T; p.L177L; 16:23680206-23680206

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.531C>T; p.L177L; 16:23680206-23680206

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.1515C>T; p.L505L; 16:23689583-23689583

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1410C>T; p.N470N; 16:23689377-23689377

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1318A>G; p.T440A; 16:23689285-23689285

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1003A>C; p.S335R; 16:23684056-23684056

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.955C>A; p.L319M; 16:23684008-23684008

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1382C>T; p.S461F; 16:23689349-23689349

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.478A>T; p.I160F; 16:23680153-23680153

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.1412_1413CC>TT; p.S471F; 16:23689379-23689380

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1469T>G; p.L490W; 16:23689537-23689537

 pancreascarcinomaSubstitution - Missense

c.1003A>T; p.S335C; 16:23684056-23684056

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.324C>G; p.L108L; 16:23679256-23679256

 breastcarcinomaSubstitution - coding silent

c.1090C>T; p.R364*; 16:23687522-23687522

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1090C>T; p.R364*; 16:23687522-23687522

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1745A>G; p.Y582C; 16:23689996-23689996

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1551C>T; p.T517T; 16:23689619-23689619

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1736G>A; p.R579Q; 16:23689987-23689987

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.874G>A; p.A292T; 16:23683927-23683927

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1573C>T; p.L525F; 16:23689641-23689641

 skinmalignant_melanomaSubstitution - Missense

c.1009C>T; p.R337W; 16:23684062-23684062

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1784C>T; p.S595L; 16:23690035-23690035

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1419_1421delGAA; p.K475delK; 16:23689386-23689388

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.451C>T; p.P151S; 16:23680126-23680126

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.738_739insT; p.G247fs*6; 16:23682079-23682080

 lungcarcinoma; adenocarcinomaInsertion - Frameshift

c.833C>A; p.A278D; 16:23683886-23683886

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.698A>G; p.D233G; 16:23681034-23681034

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1343G>T; p.G448V; 16:23689310-23689310

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.209T>A; p.I70N; 16:23679141-23679141

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.3G>A; p.M1I; 16:23678935-23678935

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1683A>C; p.T561T; 16:23689934-23689934

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.1757_1759delTGG; p.V587delV; 16:23690008-23690010

 large_intestinecarcinoma; adenocarcinomaDeletion - In frame

c.1176T>G; p.R392R; 16:23687608-23687608

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.409-1G>T; p.?; 16:23680083-23680083

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.1617C>A; p.T539T; 16:23689868-23689868

 skinmalignant_melanomaSubstitution - coding silent

c.845T>G; p.I282S; 16:23683898-23683898

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.505C>T; p.R169*; 16:23680180-23680180

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.505C>T; p.R169*; 16:23680180-23680180

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1598A>G; p.N533S; 16:23689666-23689666

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.596C>T; p.T199I; 16:23680932-23680932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.596C>T; p.T199I; 16:23680932-23680932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.658C>G; p.P220A; 16:23680994-23680994

 breastcarcinomaSubstitution - Missense

c.748C>T; p.P250S; 16:23682089-23682089

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.910T>G; p.F304V; 16:23683963-23683963

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.833C>G; p.A278G; 16:23683886-23683886

 central_nervous_system; braingliomaSubstitution - Missense

c.421C>T; p.L141L; 16:23680096-23680096

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1688G>A; p.R563H; 16:23689939-23689939

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.863C>A; p.T288K; 16:23683916-23683916

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1803G>T; p.K601N; 16:23690054-23690054

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1803G>T; p.K601N; 16:23690054-23690054

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1803G>T; p.K601N; 16:23690054-23690054

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.461G>T; p.R154L; 16:23680136-23680136

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1458G>A; p.M486I; 16:23689526-23689526

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1242G>A; p.W414*; 16:23688717-23688717

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.468_469insT; p.L157fs*30; 16:23680143-23680144

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaInsertion - Frameshift

c.1123A>G; p.S375G; 16:23687555-23687555

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1167C>T; p.P389P; 16:23687599-23687599

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1558G>A; p.A520T; 16:23689626-23689626

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.210C>T; p.I70I; 16:23679142-23679142

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.712G>T; p.G238W; 16:23681048-23681048

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.712G>T; p.G238W; 16:23681048-23681048

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1721A>C; p.K574T; 16:23689972-23689972

 thyroidother; neoplasmSubstitution - Missense

c.1110C>T; p.V370V; 16:23687542-23687542

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.1308C>T; p.F436F; 16:23689275-23689275

 skinmalignant_melanomaSubstitution - coding silent

c.1531C>A; p.L511I; 16:23689599-23689599

 pancreascarcinomaSubstitution - Missense

c.1434C>T; p.L478L; 16:23689502-23689502

 skin; armmalignant_melanomaSubstitution - coding silent

c.219G>A; p.A73A; 16:23679151-23679151

 livercarcinomaSubstitution - coding silent

c.219G>A; p.A73A; 16:23679151-23679151

 livercarcinomaSubstitution - coding silent

c.35G>T; p.R12L; 16:23678967-23678967

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.35G>T; p.R12L; 16:23678967-23678967

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.329A>G; p.H110R; 16:23679261-23679261

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1575C>T; p.L525L; 16:23689643-23689643

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.907G>T; p.E303*; 16:23683960-23683960

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.1593G>T; p.Q531H; 16:23689661-23689661

 autonomic_ganglianeuroblastomaSubstitution - Missense

c.463T>C; p.Y155H; 16:23680138-23680138

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1296delG; p.V434fs*21; 16:23689263-23689263

 stomachadenocarcinomaDeletion - Frameshift

c.463T>C; p.Y155H; 16:23680138-23680138

 livercarcinomaSubstitution - Missense

c.1525C>T; p.P509S; 16:23689593-23689593

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1525C>T; p.P509S; 16:23689593-23689593

 skinmalignant_melanomaSubstitution - Missense

c.1467C>G; p.H489Q; 16:23689535-23689535

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1010G>A; p.R337Q; 16:23684063-23684063

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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