| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5347 |
Name | PLK1 |
Synonymous | PLK|STPK13;polo-like kinase 1;PLK1;polo-like kinase 1 |
Definition | PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1 |
Position | 16p12.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
plk1(h) + p53(h) <==> plk1(h):p53(h) (binding) | plk1(h) + p53(mo) <==> plk1(h):p53(mo) (binding) | plk1(h) + LOK(h) <==> plk1(h):LOK(h) (binding) | plk1(h) + Nlp(h) <==> plk1(h):Nlp(h) (binding) | plk1(h) + MKlp1-1(ha) <==> plk1(h):MKlp1-1(ha) (binding) | plk1(h) + cyclinB1(h) <==> plk1(h):cyclinB1(h) (binding) | plk1(h) + NudC(h) <==> plk1(h):NudC(h) (binding) | plk1(h) + NudC(h) + dynactin1(h) <==> plk1(h):NudC(h):dynactin1(h) (binding) | plk1(h) + NudC(h) + CDIC(h) <==> plk1(h):NudC(h):CDIC(h) (binding) | plk1(h) + MKlp2(h){pS62}{pS528}{pS662}{pS668} <==> plk1(h):MKlp2(h){pS62}{pS528}{pS662}{pS668} (binding) | Bub1(h) + plk1(h) <==> Bub1(h):plk1(h) (binding) | plk1(h) + BubR1(h) <==> plk1(h):BubR1(h) (binding) | plk1(h) + INCENP(h) <==> plk1(h):INCENP(h) (binding) | INCENP(m) + plk1(h) <==> INCENP(m):plk1(h) (binding) | plk1(h) + Pin1(h) <==> plk1(h):Pin1(h) (binding) | plk1(h) --> Pin1(h) (increase of abundance) | plk1(h) + PRC1(h) <==> plk1(h):PRC1(h) (binding) | plk1(h) + KIF4A(m.s.) <==> plk1(h):KIF4A(m.s.) (binding) | plk1(h) + PRC1(h){pT602} <==> plk1(h):PRC1(h){pT602} (binding) | CEP55(h){p} + plk1(h) <==> CEP55(h){p}:plk1(h) (binding) | PBIP1(m.s.){pS78} + plk1(h) <==> PBIP1(m.s.){pS78}:plk1(h) (binding) | plk1(h) + ERCC6L(h) <==> plk1(h):ERCC6L(h) (binding) | TTDN1(h){p} + plk1(h) <==> TTDN1(h){p}:plk1(h) (binding) | plk1(h) + TTDN1(h){pT120} <==> plk1(h):TTDN1(h){pT120} (binding) | plk1(h) + RhoA(h) <==> plk1(h):RhoA(h) (binding) | kif2a(h) + plk1(h) <==> kif2a(h):plk1(h) (binding) | dnajb9(h) + plk1(h) <==> dnajb9(h):plk1(h) (binding) | plk1(h) + MgcRacGAP(h) + ECT2(h) <==> plk1(h):MgcRacGAP(h):ECT2(h) (binding) | plk1(h) + mdm2-isoform1(h) <==> plk1(h):mdm2-isoform1(h) (binding) | mdm2(h) + plk1(h) <==> mdm2(h):plk1(h) (binding) | PLK1(h) --> plk1(h) (expression). | CBP(h) --/ plk1(h) (decrease of abundance) | DDB1(h) --/ plk1(h) (decrease of abundance) | p53(h) + ATP --plk1(h)--> p53(h){p} + ADP (phosphorylation) | APC1(h) + ATP --plk1(h)--> APC1(h){pT520} + ADP (phosphorylation) | APC1(h) + ATP --plk1(h)--> APC1(h){pS547} + ADP (phosphorylation) | APC1(h) + ATP --plk1(h)--> APC1(h){pS688} + ADP (phosphorylation) | Cdc27(h) + ATP --plk1(h)--> Cdc27(h){pT209} + ADP (phosphorylation) | Cdc27(h) + ATP --plk1(h)--> Cdc27(h){pS426} + ADP (phosphorylation) | Cdc27(h) + ATP --plk1(h)--> Cdc27(h){pS434} + ADP (phosphorylation) | Cdc27(h) + ATP --plk1(h)--> Cdc27(h){pS435} + ADP (phosphorylation) | APC4(h) + ATP --plk1(h)--> APC4(h){pS779} + ADP (phosphorylation) | APC7(h) + ATP --plk1(h)--> APC7(h){pS17} + ADP (phosphorylation) | APC7(h) + ATP --plk1(h)--> APC7(h){pS23} + ADP (phosphorylation) | APC7(h) + ATP --plk1(h)--> APC7(h){pS30} + ADP (phosphorylation) | cyclosome(x) + ATP --cyclinB1(h):Cdk1(h):Cks1(h),plk1(h)--> cyclosome(x){p} + ADP (phosphorylation) | MKlp1-1(ha) + 2 ATP --plk1(h)--> MKlp1-1(ha){pS904}{pS905} + 2 ADP (phosphorylation) | pkmyt1(h) + 2 ATP --plk1(h)--> pkmyt1(h){pS426}{pT495} + 2 ADP (phosphorylation) | Cdc25C(h) + ATP --plk1(h)--> Cdc25C(h){pS198} + ADP (phosphorylation) | cyclinB1(h) + ATP --plk1(h)--> cyclinB1(h){pS147} + ADP (phosphorylation) | cyclinB1(h) + ATP --plk1(h)--> cyclinB1(h){pS133} + ADP (phosphorylation) | NudC(h) + 2 ATP --plk1(h)--> NudC(h){pS274}{pS326} + 2 ADP (phosphorylation) | PRC1(h) + ATP --plk1(h)--> PRC1(h){p} + ADP (phosphorylation) | MKlp1(h) + ATP --plk1(h)--> MKlp1(h){p} + ADP (phosphorylation) | MKlp2(h) + 4 ATP --plk1(h)--> MKlp2(h){pS62}{pS528}{pS662}{pS668} + 4 ADP (phosphorylation) | PRC1(h) + ATP --plk1(h)--> PRC1(h){pT602} + ADP (phosphorylation) | BubR1(h) + ATP --plk1(h)--> BubR1(h){pS676} + ADP (phosphorylation) | BubR1(m.s.) + ATP --plk1(h)--> BubR1(m.s.){pS676} + ADP (phosphorylation) | BubR1(h) + n ATP --plk1(h)--> BubR1(h){p}n + n ADP (phosphorylation) | Casein(m.s.) + ATP --plk1(h)--> Casein(m.s.){p} + ADP (phosphorylation) | Bub1(h) + plk1(h) <==> Bub1(h):plk1(h) (binding) | INCENP(m) + plk1(h) <==> INCENP(m):plk1(h) (binding) | Emi1(h) + plk1(h) <==> Emi1(h):plk1(h) (binding) | plk1(h) + Vimentin(m){pS55} <==> plk1(h):Vimentin(m){pS55} (binding) | plk1(h) + vimentin(h){pS55} <==> plk1(h):vimentin(h){pS55} (binding) | Evi5(h) + plk1(h) <==> Evi5(h):plk1(h) (binding) | ERCC6L(h) + plk1(h) <==> ERCC6L(h):plk1(h) (binding) | plk1(h) + BubR1(h){p} <==> plk1(h):BubR1(h){p} (binding) | Cdc14A2(h) + plk1(h) <==> Cdc14A2(h):plk1(h) (binding) | plk1(h) + Separin(h){pS1126} <==> plk1(h):Separin(h){pS1126} (binding) | PLK1(h) --> plk1(h) (expression). | Bub1(h) + ATP --plk1(h)--> Bub1(h){p} + ADP (phosphorylation) | Casein(m.s.) + ATP --plk1(h)--> Casein(m.s.){p} + ADP (phosphorylation) | Vimentin(m) + ATP --plk1(h)--> Vimentin(m){pS82} + ADP (phosphorylation) | BubR1(h) + ATP --plk1(h)--> BubR1(h){p} + ADP (phosphorylation) | MgcRacGAP(h) + ATP --plk1(h)--> MgcRacGAP(h){p} + ADP (phosphorylation) | ECT2(m.s.) + ATP --plk1(h)--> ECT2(m.s.){p} + ADP (phosphorylation) | MgcRacGAP(h) + 4 ATP --plk1(h)--> MgcRacGAP(h){pS149}{pS157}{pS164}{pS170} + 4 ADP (phosphorylation) | MgcRacGAP(h) + 4 ATP --plk1(h)--> MgcRacGAP(h){pS157}{pS170}{pS214}{pT260} + 4 ADP (phosphorylation) | mdm2-isoform1(m) + ATP --plk1(h)--> mdm2-isoform1(m){pS258} + ADP (phosphorylation) | mdm2-isoform1(h) + ATP --plk1(h)--> mdm2-isoform1(h){pS260} + ADP (phosphorylation) | p53(h) + ATP --plk1(h)--> p53(h){p} + ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
137 | Phosphoserine; in vitro. | Swiss-Prot 53.0 | 210 | Phosphothreonine. | Swiss-Prot 53.0 | 269 | Phosphoserine; by autocatalysis (Bysimilarity). | Swiss-Prot 53.0 | 335 | Phosphoserine. | Swiss-Prot 53.0 | 210 | Phosphothreonine (LOK) | 12207013 | Phospho.ELM 6.0 | 137 | Phosphoserine | 15713655 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr16 |
Promoter: 23596202 - 23598202 | Agilent_014791 |
chr16 |
Promoter: 23596202 - 23598202 | GSE27584 |
chr16 |
Promoter: 23596202 - 23598202 | Agilent_014791_44K |
chr16 |
Promoter: 23596202 - 23598202 | Agilent_014791 |