| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5515 |
Name | PPP2CA |
Synonym | PP2Ac|PP2CA|PP2Calpha|RP-C;protein phosphatase 2, catalytic subunit, alpha isozyme;PPP2CA;protein phosphatase 2, catalytic subunit, alpha isozyme |
Definition | PP2A-alpha|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform|protein phosphatase 2A catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-prote |
Position | 5q31.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 13228 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | p53 pathway by glucose deprivation;PANTHER;P04397 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | akt signaling pathway;PID BioCarta;100245 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | C-MYC pathway;PID Curated;200093 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | PLK1 signaling events;PID Curated;200087 |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | Metabolism of carbohydrates;Reactome;REACT:474 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | regulation of eif-4e and p70s6 kinase;PID BioCarta;100178 |
Pathway | DNA Replication;Reactome;REACT:383 |
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External Links |
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Links to Entrez Gene | 5515 |
Links to all GeneRIF Items | 5515 |
Links to iHOP | 5515 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5515 : length: 930 atggacgagaaggtgttcaccaaggagctggaccagtggatcgagcagctgaacgagtgc aagcagctgtccgagtcccaggtcaagagcctctgcgagaaggctaaagaaatcctgaca aaagaatccaacgtgcaagaggttcgatgtccagttactgtctgtggagatgtgcatggg caatttcatgatctcatggaactgtttagaattggtggcaaatcaccagatacaaattac ttgtttatgggagattatgttgacagaggatattattcagttgaaacagttacactgctt gtagctcttaaggttcgttaccgtgaacgcatcaccattcttcgagggaatcatgagagc agacagatcacacaagtttatggtttctatgatgaatgtttaagaaaatatggaaatgca aatgtttggaaatattttacagatctttttgactatcttcctctcactgccttggtggat gggcagatcttctgtctacatggtggtctctcgccatctatagatacactggatcatatc agagcacttgatcgcctacaagaagttccccatgagggtccaatgtgtgacttgctgtgg tcagatccagatgaccgtggtggttggggtatatctcctcgaggagctggttacaccttt gggcaagatatttctgagacatttaatcatgccaatggcctcacgttggtgtctagagct caccagctagtgatggagggatataactggtgccatgaccggaatgtagtaacgattttc agtgctccaaactattgttatcgttgtggtaaccaagctgcaatcatggaacttgacgat actctaaaatactctttcttgcagtttgacccagcacctcgtagaggcgagccacatgtt actcgtcgtaccccagactacttcctgtaa |
Protein Sequence |
>5515 : length: 309 MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV TRRTPDYFL |