Entrez Gene

Basic Information
Gene ID	5515
Name	PPP2CA
Synonymous	PP2Ac\|PP2CA\|PP2Calpha\|RP-C;protein phosphatase 2, catalytic subunit, alpha isozyme;PPP2CA;protein phosphatase 2, catalytic subunit, alpha isozyme
Definition	PP2A-alpha\|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform\|protein phosphatase 2A catalytic subunit, alpha isoform\|replication protein C\|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform\|serine/threonine-prote
Position	5q31.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
axin(h) + GSK3beta(h) + PR65(h) + PP2ACalpha(h) + beta-catenin(h) <==> axin(h):beta-catenin(h):GSK3beta(h):PP2ACalpha(h):PR65(h) (binding)
Aurora-B(h) + PP2ACalpha(h) <==> Aurora-B(h):PP2ACalpha(h) (binding)
PPP2CA(h) --> PP2ACalpha(h) (expression).
RelA-p65(h){pS} --PP2ACalpha(h)--> RelA-p65(h) + p (dephosphorylation)
PKCalpha(h) + PP2ACalpha(h) <==> PKCalpha(h):PP2ACalpha(h) (binding)
Sgo1(h) + PP2ACalpha(h) <==> Sgo1(h):PP2ACalpha(h) (binding)
PR65-alpha(h) + PP2ACalpha(h) + B56gamma(h) <==> PR65-alpha(h):PP2ACalpha(h):B56gamma(h) (binding)
PP2ACalpha(h) + TRIP-13(h) <==> PP2ACalpha(h):TRIP-13(h) (binding)
PP2ACalpha(h) + PTN(h) <==> PP2ACalpha(h):PTN(h) (binding)
PP2ACalpha(h) + B55A(h) + alpha-tubulin 1B(h) + PR65-beta(h) + Hsp70-1(h) + vcp(h) <==> PP2ACalpha(h):B55A(h):alpha-tubulin 1B(h):PR65-beta(h):Hsp70-1(h):vcp(h) (binding)
PPP2CA(h) --> PP2ACalpha(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
307	Phosphotyrosine.		Swiss-Prot 53.0
309	Leucine methyl ester.		Swiss-Prot 53.0
304	Phosphothreonine	10978272	Phospho.ELM 6.0
307	Phosphotyrosine	16286244	Phospho.ELM 6.0