| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5579 |
Name | PRKCB |
Synonym | PKC-beta|PKCB|PRKCB1|PRKCB2;protein kinase C, beta;PRKCB;protein kinase C, beta |
Definition | PKC-B|protein kinase C beta type|protein kinase C, beta 1 polypeptide |
Position | 16p11.2 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 13335 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Vibrio cholerae infection;KEGG PATHWAY;hsa05110 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Metabotropic glutamate receptor group I pathway;PANTHER;P00041 |
Pathway | JNK signaling in the CD4+ TCR pathway;PID Curated;200129 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway;PANTHER;P00042 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Ras signaling in the CD4+ TCR pathway;PID Curated;200088 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | ionomycin and phorbal ester signaling pathway;PID BioCarta;100121 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | nephropathy, diabetic;GAD |
Disease | RENAL;GAD |
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External Links |
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Links to Entrez Gene | 5579 |
Links to all GeneRIF Items | 5579 |
Links to iHOP | 5579 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5579 : length: 2022 atggctgacccggctgcggggccgccgccgagcgagggcgaggagagcaccgtgcgcttc gcccgcaaaggcgccctccggcagaagaacgtgcatgaggtcaagaaccacaaattcacc gcccgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctggggcttc gggaagcagggattccagtgccaagtttgctgctttgtggtgcacaagcggtgccatgaa tttgtcacattctcctgccctggcgctgacaagggtccagcctccgatgacccccgcagc aaacacaagtttaagatccacacgtactccagccccacgttttgtgaccactgtgggtca ctgctgtatggactcatccaccaggggatgaaatgtgacacctgcatgatgaatgtgcac aagcgctgcgtgatgaatgttcccagcctgtgtggcacggaccacacggagcgccgcggc cgcatctacatccaggcccacatcgacagggacgtcctcattgtcctcgtaagagatgct aaaaaccttgtacctatggaccccaatggcctgtcagatccctacgtaaaactgaaactg attcccgatcccaaaagtgagagcaaacagaagaccaaaaccatcaaatgctccctcaac cctgagtggaatgagacatttagatttcagctgaaagaatcggacaaagacagaagactg tcagtagagatttgggattgggatttgaccagcaggaatgacttcatgggatctttgtcc tttgggatttctgaacttcagaaagccagtgttgatggctggtttaagttactgagccag gaggaaggcgagtacttcaatgtgcctgtgccaccagaaggaagtgaggccaatgaagaa ctgcggcagaaatttgagagggccaagatcagtcagggaaccaaggtcccggaagaaaag acgaccaacactgtctccaaatttgacaacaatggcaacagagaccggatgaaactgacc gattttaacttcctaatggtgctggggaaaggcagctttggcaaggtcatgctttcagaa cgaaaaggcacagatgagctctatgctgtgaagatcctgaagaaggacgttgtgatccaa gatgatgacgtggagtgcactatggtggagaagcgggtgttggccctgcctgggaagccg cccttcctgacccagctccactcctgcttccagaccatggaccgcctgtactttgtgatg gagtacgtgaatgggggcgacctcatgtatcacatccagcaagtcggccggttcaaggag ccccatgctgtattttacgctgcagaaattgccatcggtctgttcttcttacagagtaag ggcatcatttaccgtgacctaaaacttgacaacgtgatgctcgattctgagggacacatc aagattgccgattttggcatgtgtaaggaaaacatctgggatggggtgacaaccaagaca ttctgtggcactccagactacatcgcccccgagataattgcttatcagccctatgggaag tccgtggattggtgggcatttggagtcctgctgtatgaaatgttggctgggcaggcaccc tttgaaggggaggatgaagatgaactcttccaatccatcatggaacacaacgtagcctat cccaagtctatgtccaaggaagctgtggccatctgcaaagggctgatgaccaaacaccca ggcaaacgtctgggttgtggacctgaaggcgaacgtgatatcaaagagcatgcatttttc cggtatattgattgggagaaacttgaacgcaaagagatccagcccccttataagccaaaa gcttgtgggcgaaatgctgaaaacttcgaccgatttttcacccgccatccaccagtccta acacctcccgaccaggaagtcatcaggaatattgaccaatcagaattcgaaggattttcc tttgttaactctgaatttttaaaacccgaagtcaagagctaa |
Protein Sequence |
>5579 : length: 673 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF RYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFS FVNSEFLKPEVKS |