Entrez Gene

Basic Information
Gene ID	5579
Name	PRKCB
Synonymous	protein kinase C, beta;PRKCB;protein kinase C, beta
Definition	PKC-B\|protein kinase C beta type\|protein kinase C, beta 1 polypeptide
Position	16p11.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1805A>T; p.Y602F; 16:24191172-24191172	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1536A>G; p.I512M; 16:24185113-24185113	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>T; p.D383D; 16:24154767-24154767	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1149C>T; p.D383D; 16:24154767-24154767	lung	carcinoid-endocrine_tumour; typical	Substitution - coding silent
c.1116C>T; p.I372I; 16:24154734-24154734	skin	malignant_melanoma	Substitution - coding silent
c.1708G>A; p.A570T; 16:24185553-24185553	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1455T>C; p.F485F; 16:24180850-24180850	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.149G>C; p.C50S; 16:23836324-23836324	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.199T>A; p.C67S; 16:23837400-23837400	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.785G>T; p.G262V; 16:24094261-24094261	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1724T>C; p.L575P; 16:24191091-24191091	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1417_1418AT>TA; p.M473*; 16:24180812-24180813	skin	malignant_melanoma	Substitution - Nonsense
c.1682C>A; p.P561H; 16:24185527-24185527	skin	malignant_melanoma	Substitution - Missense
c.1803G>T; p.R601R; 16:24191170-24191170	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1448C>T; p.A483V; 16:24180843-24180843	skin	malignant_melanoma	Substitution - Missense
c.450G>T; p.L150L; 16:24035468-24035468	liver	carcinoma	Substitution - coding silent
c.1947G>A; p.R649R; 16:24214741-24214741	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1314C>T; p.F438F; 16:24172344-24172344	skin	malignant_melanoma	Substitution - coding silent
c.970A>G; p.T324A; 16:24123886-24123886	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1126G>A; p.D376N; 16:24154744-24154744	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1082G>A; p.R361Q; 16:24154700-24154700	skin	malignant_melanoma	Substitution - Missense
c.1082G>A; p.R361Q; 16:24154700-24154700	skin	malignant_melanoma	Substitution - Missense
c.1332A>T; p.V444V; 16:24174518-24174518	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1082G>A; p.R361Q; 16:24154700-24154700	skin	malignant_melanoma	Substitution - Missense
c.1191T>C; p.P397P; 16:24154809-24154809	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.260C>A; p.P87H; 16:23988562-23988562	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1043T>A; p.L348Q; 16:24123959-24123959	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1144G>A; p.D382N; 16:24154762-24154762	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1356C>G; p.I452M; 16:24174542-24174542	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.265G>T; p.A89S; 16:23988567-23988567	oesophagus	carcinoma	Substitution - Missense
c.1065G>T; p.K355N; 16:24123981-24123981	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1771G>A; p.E591K; 16:24191138-24191138	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1771G>A; p.E591K; 16:24191138-24191138	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1582G>C; p.G528R; 16:24185159-24185159	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.431T>C; p.V144A; 16:24035449-24035449	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>A; p.E157K; 16:24035487-24035487	skin	malignant_melanoma	Substitution - Missense
c.1818G>A; p.E606E; 16:24191185-24191185	skin	malignant_melanoma	Substitution - coding silent
c.585C>T; p.Y195Y; 16:24092846-24092846	pancreas	carcinoma	Substitution - coding silent
c.603T>C; p.I201I; 16:24092864-24092864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1443G>A; p.K481K; 16:24180838-24180838	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1218C>A; p.L406L; 16:24154836-24154836	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.60C>T; p.F20F; 16:23836235-23836235	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1218C>A; p.L406L; 16:24154836-24154836	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - coding silent
c.1218C>A; p.L406L; 16:24154836-24154836	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.1987A>C; p.N663H; 16:24214781-24214781	liver	carcinoma	Substitution - Missense
c.1987A>C; p.N663H; 16:24214781-24214781	liver	carcinoma	Substitution - Missense
c.786G>T; p.G262G; 16:24094262-24094262	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.18G>T; p.A6A; 16:23836193-23836193	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1211C>T; p.T404I; 16:24154829-24154829	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.450G>A; p.L150L; 16:24035468-24035468	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1860A>G; p.K620K; 16:24191227-24191227	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.962C>T; p.T321M; 16:24123878-24123878	skin	malignant_melanoma	Substitution - Missense
c.756G>A; p.R252R; 16:24094232-24094232	skin	malignant_melanoma	Substitution - coding silent
c.1856C>A; p.P619Q; 16:24191223-24191223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.530T>C; p.V177A; 16:24092791-24092791	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.965C>T; p.T322I; 16:24123881-24123881	skin	malignant_melanoma	Substitution - Missense
c.1752G>T; p.L584L; 16:24191119-24191119	oesophagus	carcinoma	Substitution - coding silent
c.541delA; p.N182fs*15; 16:24092802-24092802	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1032C>T; p.F344F; 16:24123948-24123948	skin	malignant_melanoma	Substitution - coding silent
c.1382G>C; p.G461A; 16:24174568-24174568	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1422C>T; p.L474L; 16:24180817-24180817	skin	malignant_melanoma	Substitution - coding silent
c.1055G>A; p.S352N; 16:24123971-24123971	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1143T>C; p.D381D; 16:24154761-24154761	liver	carcinoma	Substitution - coding silent
c.1802G>A; p.R601Q; 16:24191169-24191169	skin	malignant_melanoma	Substitution - Missense
c.959A>G; p.K320R; 16:24123875-24123875	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1544A>T; p.Y515F; 16:24185121-24185121	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.545A>T; p.N182I; 16:24092806-24092806	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.765C>T; p.F255F; 16:24094241-24094241	skin	malignant_melanoma	Substitution - coding silent
c.1186C>T; p.L396L; 16:24154804-24154804	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1255G>T; p.V419L; 16:24172285-24172285	liver	carcinoma	Substitution - Missense
c.1255G>T; p.V419L; 16:24172285-24172285	breast	carcinoma	Substitution - Missense
c.1255G>T; p.V419L; 16:24172285-24172285	liver	carcinoma	Substitution - Missense
c.1904G>T; p.R635L; 16:24214698-24214698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1892G>A; p.R631Q; 16:24214686-24214686	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1892G>A; p.R631Q; 16:24214686-24214686	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1892G>A; p.R631Q; 16:24214686-24214686	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.V144M; 16:24035448-24035448	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.430G>A; p.V144M; 16:24035448-24035448	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.107A>C; p.N36T; 16:23836282-23836282	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.264C>T; p.G88G; 16:23988566-23988566	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1834G>C; p.E612Q; 16:24191201-24191201	breast	carcinoma	Substitution - Missense
c.79C>A; p.R27R; 16:23836254-23836254	thyroid	other; neoplasm	Substitution - coding silent
c.18G>A; p.A6A; 16:23836193-23836193	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1199C>T; p.P400L; 16:24154817-24154817	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1238_1239TG>AT; p.M413N; 16:24154856-24154857	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.785G>A; p.G262E; 16:24094261-24094261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1554T>C; p.Y518Y; 16:24185131-24185131	breast	carcinoma	Substitution - coding silent
c.79C>A; p.R27R; 16:23836254-23836254	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.79C>A; p.R27R; 16:23836254-23836254	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.79C>A; p.R27R; 16:23836254-23836254	breast	carcinoma	Substitution - coding silent
c.649T>C; p.C217R; 16:24092910-24092910	skin	malignant_melanoma	Substitution - Missense
c.580C>T; p.P194S; 16:24092841-24092841	skin	malignant_melanoma	Substitution - Missense
c.1394G>A; p.R465H; 16:24174580-24174580	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.78C>T; p.L26L; 16:23836253-23836253	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.78C>T; p.L26L; 16:23836253-23836253	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.586G>A; p.V196I; 16:24092847-24092847	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1741G>T; p.G581C; 16:24191108-24191108	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1671C>T; p.N557N; 16:24185516-24185516	liver	carcinoma	Substitution - coding silent
c.1671C>T; p.N557N; 16:24185516-24185516	liver	carcinoma	Substitution - coding silent
c.1119G>A; p.L373L; 16:24154737-24154737	skin	malignant_melanoma	Substitution - coding silent
c.290_291insC; p.R99fs*7; 16:24032137-24032138	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.606C>T; p.P202P; 16:24092867-24092867	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.528C>A; p.L176L; 16:24035546-24035546	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1690A>G; p.M564V; 16:24185535-24185535	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1295T>C; p.I432T; 16:24172325-24172325	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.408G>A; p.M136I; 16:24035426-24035426	skin	malignant_melanoma	Substitution - Missense
c.296G>A; p.R99H; 16:24032143-24032143	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.61G>A; p.A21T; 16:23836236-23836236	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1871G>A; p.R624Q; 16:24214665-24214665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1021G>A; p.D341N; 16:24123937-24123937	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.189G>T; p.Q63H; 16:23837390-23837390	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1913C>T; p.P638L; 16:24214707-24214707	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.532A>C; p.R178R; 16:24092793-24092793	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1450G>A; p.D484N; 16:24180845-24180845	skin	malignant_melanoma	Substitution - Missense
c.163G>A; p.D55N; 16:23836338-23836338	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>T; p.P112P; 16:24032183-24032183	skin	malignant_melanoma	Substitution - coding silent
c.1339G>A; p.A447T; 16:24174525-24174525	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1846C>A; p.P616T; 16:24191213-24191213	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1885T>A; p.F629I; 16:24214679-24214679	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1395-4A>T; p.?; 16:24180786-24180786	kidney	other; neoplasm	Unknown
c.544A>T; p.N182Y; 16:24092805-24092805	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.544A>T; p.N182Y; 16:24092805-24092805	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.623G>A; p.S208N; 16:24092884-24092884	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1200G>A; p.P400P; 16:24154818-24154818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1200G>A; p.P400P; 16:24154818-24154818	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1789C>G; p.H597D; 16:24191156-24191156	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1200G>A; p.P400P; 16:24154818-24154818	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1200G>A; p.P400P; 16:24154818-24154818	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.725T>C; p.V242A; 16:24094201-24094201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200G>A; p.P400P; 16:24154818-24154818	central_nervous_system; brain	glioma	Substitution - coding silent
c.1200G>A; p.P400P; 16:24154818-24154818	central_nervous_system; brain	glioma	Substitution - coding silent
c.1485G>A; p.G495G; 16:24180880-24180880	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1188G>T; p.L396L; 16:24154806-24154806	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1188G>T; p.L396L; 16:24154806-24154806	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1480G>A; p.D494N; 16:24180875-24180875	skin	malignant_melanoma	Substitution - Missense
c.1480G>A; p.D494N; 16:24180875-24180875	skin	malignant_melanoma	Substitution - Missense
c.1362G>C; p.L454L; 16:24174548-24174548	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1406T>C; p.L469P; 16:24180801-24180801	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1406T>C; p.L469P; 16:24180801-24180801	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1279G>A; p.D427N; 16:24172309-24172309	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.938G>T; p.G313V; 16:24123854-24123854	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1870C>T; p.R624*; 16:24214664-24214664	pancreas	carcinoma	Substitution - Nonsense
c.653C>T; p.S218F; 16:24092914-24092914	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1493C>T; p.T498I; 16:24180888-24180888	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.920G>T; p.R307M; 16:24123836-24123836	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.232T>C; p.C78R; 16:23988534-23988534	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1557G>A; p.G519G; 16:24185134-24185134	skin	malignant_melanoma	Substitution - coding silent
c.1486G>A; p.V496M; 16:24180881-24180881	central_nervous_system; brain	glioma	Substitution - Missense
c.1486G>A; p.V496M; 16:24180881-24180881	central_nervous_system; brain	glioma	Substitution - Missense
c.745T>A; p.L249M; 16:24094221-24094221	kidney	other; neoplasm	Substitution - Missense
c.1428T>C; p.S476S; 16:24180823-24180823	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.922G>A; p.A308T; 16:24123838-24123838	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1636G>T; p.E546*; 16:24185481-24185481	liver	carcinoma	Substitution - Nonsense
c.834G>A; p.L278L; 16:24112985-24112985	skin	malignant_melanoma	Substitution - coding silent
c.1093G>A; p.D365N; 16:24154711-24154711	breast	carcinoma	Substitution - Missense
c.177C>T; p.G59G; 16:23837378-23837378	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1698G>A; p.K566K; 16:24185543-24185543	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1904G>A; p.R635H; 16:24214698-24214698	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>T; p.S95S; 16:23988587-23988587	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.285C>T; p.S95S; 16:23988587-23988587	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.309G>T; p.K103N; 16:24032156-24032156	thyroid	other; neoplasm	Substitution - Missense
c.607G>A; p.D203N; 16:24092868-24092868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1068C>T; p.V356V; 16:24154686-24154686	skin	malignant_melanoma	Substitution - coding silent
c.607G>A; p.D203N; 16:24092868-24092868	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.668G>A; p.W223*; 16:24092929-24092929	skin	malignant_melanoma	Substitution - Nonsense
c.1768G>T; p.G590C; 16:24191135-24191135	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.731T>C; p.I244T; 16:24094207-24094207	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1567G>A; p.D523N; 16:24185144-24185144	skin	malignant_melanoma	Substitution - Missense
c.545delA; p.N182fs*15; 16:24092806-24092806	large_intestine; colon	carcinoma	Deletion - Frameshift
c.960G>A; p.K320K; 16:24123876-24123876	skin	malignant_melanoma	Substitution - coding silent
c.1357G>A; p.G453S; 16:24174543-24174543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>A; p.R178K; 16:24092794-24092794	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1206C>T; p.F402F; 16:24154824-24154824	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.157T>G; p.C53G; 16:23836332-23836332	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.475C>T; p.R159C; 16:24035493-24035493	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.657C>G; p.L219L; 16:24092918-24092918	breast	carcinoma	Substitution - coding silent
c.1525G>A; p.A509T; 16:24180920-24180920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.A509T; 16:24180920-24180920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.A509T; 16:24180920-24180920	large_intestine; colon	carcinoma	Substitution - Missense
c.56G>T; p.R19L; 16:23836231-23836231	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.A509T; 16:24180920-24180920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.A509T; 16:24180920-24180920	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.55C>T; p.R19C; 16:23836230-23836230	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>A; p.V18M; 16:23836227-23836227	skin	malignant_melanoma	Substitution - Missense
c.1968C>T; p.F656F; 16:24214762-24214762	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.756G>T; p.R252S; 16:24094232-24094232	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.477C>T; p.R159R; 16:24035495-24035495	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.263G>A; p.G88D; 16:23988565-23988565	pancreas	carcinoma	Substitution - Missense
c.1224C>G; p.S408S; 16:24154842-24154842	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1304T>C; p.V435A; 16:24172334-24172334	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1753G>A; p.G585S; 16:24191120-24191120	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1224C>G; p.S408S; 16:24154842-24154842	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1618C>T; p.P540S; 16:24185463-24185463	skin	malignant_melanoma	Substitution - Missense
c.1615G>A; p.A539T; 16:24185460-24185460	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1156T>C; p.C386R; 16:24154774-24154774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1156T>A; p.C386S; 16:24154774-24154774	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1526C>T; p.A509V; 16:24180921-24180921	breast	carcinoma	Substitution - Missense
c.403T>G; p.C135G; 16:24035421-24035421	liver	carcinoma	Substitution - Missense
c.173+8C>T; p.?; 16:23836356-23836356	pancreas	carcinoma	Unknown
c.318C>T; p.I106I; 16:24032165-24032165	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.403T>G; p.C135G; 16:24035421-24035421	liver	carcinoma	Substitution - Missense
c.403T>G; p.C135G; 16:24035421-24035421	liver	carcinoma	Substitution - Missense
c.533G>T; p.R178I; 16:24092794-24092794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.895G>A; p.E299K; 16:24113046-24113046	skin	malignant_melanoma	Substitution - Missense
c.1433G>A; p.G478E; 16:24180828-24180828	skin	malignant_melanoma	Substitution - Missense
c.2018G>A; p.S673N; 16:24214812-24214812	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1663G>A; p.E555K; 16:24185508-24185508	skin	malignant_melanoma	Substitution - Missense
c.560A>G; p.D187G; 16:24092821-24092821	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1550C>A; p.P517H; 16:24185127-24185127	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.716G>T; p.R239I; 16:24094192-24094192	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1893_1894insT; p.T634fs*19; 16:24214687-24214688	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1774C>T; p.R592C; 16:24191141-24191141	breast	carcinoma	Substitution - Missense
c.1656C>T; p.S552S; 16:24185501-24185501	skin	malignant_melanoma	Substitution - coding silent
c.1636G>A; p.E546K; 16:24185481-24185481	skin	malignant_melanoma	Substitution - Missense
c.610C>T; p.P204S; 16:24092871-24092871	skin	malignant_melanoma	Substitution - Missense
c.1318G>A; p.E440K; 16:24172348-24172348	skin	malignant_melanoma	Substitution - Missense
c.1723C>T; p.L575L; 16:24191090-24191090	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1155G>T; p.E385D; 16:24154773-24154773	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1168G>A; p.E390K; 16:24154786-24154786	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.827A>T; p.K276M; 16:24112978-24112978	breast	carcinoma	Substitution - Missense
c.238G>A; p.E80K; 16:23988540-23988540	skin	malignant_melanoma	Substitution - Missense
c.1503C>A; p.F501L; 16:24180898-24180898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1202C>A; p.P401H; 16:24154820-24154820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1887C>T; p.F629F; 16:24214681-24214681	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1336T>C; p.Y446H; 16:24174522-24174522	skin	malignant_melanoma	Substitution - Missense
c.423G>A; p.K141K; 16:24035441-24035441	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.482G>A; p.R161H; 16:24035500-24035500	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.884G>T; p.S295I; 16:24113035-24113035	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1334T>C; p.F445S; 16:24174520-24174520	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1563C>T; p.S521S; 16:24185140-24185140	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1039G>A; p.V347M; 16:24123955-24123955	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.286G>A; p.D96N; 16:23988588-23988588	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1044G>A; p.L348L; 16:24123960-24123960	breast	carcinoma	Substitution - coding silent
c.1854G>T; p.K618N; 16:24191221-24191221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1332-9T>A; p.?; 16:24174509-24174509	liver	carcinoma	Unknown
c.229C>T; p.R77W; 16:23988531-23988531	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1546C>T; p.Q516*; 16:24185123-24185123	skin	malignant_melanoma	Substitution - Nonsense
c.1007G>A; p.R336Q; 16:24123923-24123923	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1007G>A; p.R336Q; 16:24123923-24123923	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1132G>A; p.V378M; 16:24154750-24154750	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.784G>T; p.G262W; 16:24094260-24094260	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1829G>A; p.R610H; 16:24191196-24191196	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]