Entrez Gene

Basic Information
Gene ID	5579
Name	PRKCB
Synonymous	PKC-beta\|PKCB\|PRKCB1\|PRKCB2;protein kinase C, beta;PRKCB;protein kinase C, beta
Definition	PKC-B\|protein kinase C beta type\|protein kinase C, beta 1 polypeptide
Position	16p11.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
PKCbeta(h) + ATP --> PKCbeta(h){p} + ADP (phosphorylation)
PKCbeta(h) + ATP --> PKCbeta(h){pS660} + ADP (phosphorylation)
IFNAR2(h) + PKCbeta(h) <==> IFNAR2(h):PKCbeta(h) (binding)
Jak1(h) + SHP-2(h) + PKCbeta(h) + RACK1(h) <==> RACK1(h):SHP-2(h):Jak1(h):PKCbeta(h) (binding)
PRKCB1(h) --> PKCbeta(h) (expression).
phlpp1(h) --/ PKCbeta(h) (decrease of abundance)
phlpp2(h) --/ PKCbeta(h) (decrease of abundance)
Raf-1(h) + ATP --PKCbeta(h)--> Raf-1(h){p} + ADP (phosphorylation)
PKCbeta1(h) + ATP --> PKCbeta1(h){p} + ADP (phosphorylation)
PRKCB1(h) --> PKCbeta1(h) (expression).
PLCbeta3(h) + ATP --PKCbeta1(h)--> PLCbeta3(h){p} + ADP (phosphorylation)
CYP7(h) + ATP --PKCbeta1(h)--> CYP7(h){p} + ADP (phosphorylation)
PKCbeta2(h) + ATP --> PKCbeta2(h){p} + ADP (phosphorylation)
PRKCB1(h) --> PKCbeta2(h) (expression).
PPARalpha(m.s.) + 2 ATP --PKCbeta2(h)--> PPARalpha(m.s.){pS179}{pS230} + 2 ADP (phosphorylation)
CYP7(h) + ATP --PKCbeta2(h)--> CYP7(h){p} + ADP (phosphorylation)
CLIC4(m.s.) + ATP --PKCbeta2(h)--> CLIC4(m.s.){p} + ADP (phosphorylation)
CLIC1(m.s.) + ATP --PKCbeta2(h)--> CLIC1(m.s.){p} + ADP (phosphorylation)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
2	N-acetylalanine.		Swiss-Prot 53.0
16	Phosphoserine (by autocatalysis)(Potential).		Swiss-Prot 53.0
17	Phosphothreonine (by autocatalysis)(Potential).		Swiss-Prot 53.0
314	Phosphothreonine (by autocatalysis)(Potential).		Swiss-Prot 53.0
324	Phosphothreonine (by autocatalysis)(Potential).		Swiss-Prot 53.0
500	Phosphothreonine.		Swiss-Prot 53.0
504	Phosphothreonine.		Swiss-Prot 53.0
635	Phosphothreonine (by autocatalysis).		Swiss-Prot 53.0
642	Phosphothreonine.		Swiss-Prot 53.0
661	Phosphoserine (by autocatalysis) (Bysimilarity).		Swiss-Prot 53.0
641	Phosphothreonine	15314172	Phospho.ELM 6.0