| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5581 |
Name | PRKCE |
Synonym | PKCE|nPKC-epsilon;protein kinase C, epsilon;PRKCE;protein kinase C, epsilon |
Definition | protein kinase C epsilon type |
Position | 2p21 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 698 |
TUSON P-value | 0.021116762 |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway;PANTHER;P00042 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | LPA4-mediated signaling events;PID Curated;200036 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | cardiac protection against ros;PID BioCarta;100163 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | protein kinase a at the centrosome;PID BioCarta;100246 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | phosphoinositides and their downstream targets;PID BioCarta;100059 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Disease | Hematocrit;NHGRI |
Disease | HEMATOLOGICAL;GAD |
Disease | Hematological and biochemical traits;NHGRI |
Disease | Hemoglobin;NHGRI |
Disease | hemoglobin;GAD |
Disease | hematocrit;GAD |
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External Links |
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Links to Entrez Gene | 5581 |
Links to all GeneRIF Items | 5581 |
Links to iHOP | 5581 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5581 : length: 2214 atggtagtgttcaatggccttcttaagatcaaaatctgcgaggccgtgagcttgaagccc acagcctggtcgctgcgccatgcggtgggaccccggccgcagactttccttctcgacccc tacattgccctcaatgtggacgactcgcgcatcggccaaacggccaccaagcagaagacc aacagcccggcctggcacgacgagttcgtcaccgatgtgtgcaacggacgcaagatcgag ctggctgtctttcacgatgcccccataggctacgacgacttcgtggccaactgcaccatc cagtttgaggagctgctgcagaacgggagccgccacttcgaggactggattgatctggag ccagaaggaagagtgtatgtgatcatcgatctctcagggtcgtcgggtgaagcccctaaa gacaatgaagagcgtgtgttcagggaacgcatgcggccgaggaagcggcagggggccgtc aggcgcagggtccatcaggtcaacggccacaagttcatggccacctatcttcggcagccc acctactgctcccattgcagagacttcatctggggtgtcataggaaagcagggataccag tgtcaagtctgcacctgcgtggtccacaagcggtgccacgagctcataatcacaaagtgt gctgggttaaagaagcaggagacccccgaccaggtgggctcccagcggttcagcgtcaac atgccccacaagttcggtatccacaactacaaggtccctaccttctgcgatcactgtggg tccctgctctggggactcttgcggcagggtttgcagtgtaaagtctgcaaaatgaatgtt caccgtcgatgtgagaccaacgtggctcccaactgtggagtggatgccagaggaatcgcc aaagtactggccgacctgggcgttaccccagacaaaatcaccaacagcggccagagaagg aaaaagctcattgctggtgccgagtccccgcagcctgcttctggaagctcaccatctgag gaagatcgatccaagtcagcacccacctccccttgtgaccaggaaataaaagaacttgag aacaacattcggaaagccttgtcatttgacaaccgaggagaggagcaccgggcagcatcg tctcctgatggccagctgatgagccccggtgagaatggcgaagtccggcaaggccaggcc aagcgcctgggcctggatgagttcaacttcatcaaggtgttgggcaaaggcagctttggc aaggtcatgttggcagaactcaagggcaaagatgaagtatatgctgtgaaggtcttaaag aaggacgtcatccttcaggatgatgacgtggactgcacaatgacagagaagaggattttg gctctggcacggaaacacccgtaccttacccaactctactgctgcttccagaccaaggac cgcctctttttcgtcatggaatatgtaaatggtggagacctcatgtttcagattcagcgc tcccgaaaattcgacgagcctcgttcacggttctatgctgcagaggtcacatcggccctc atgttcctccaccagcatggagtcatctacagggatttgaaactggacaacatccttctg gatgcagaaggtcactgcaagctggctgacttcgggatgtgcaaggaagggattctgaat ggtgtgacgaccaccacgttctgtgggactcctgactacatagctcctgagatcctgcag gagttggagtatggcccctccgtggactggtgggccctgggggtgctgatgtacgagatg atggctggacagcctccctttgaggccgacaatgaggacgacctatttgagtccatcctc catgacgacgtgctgtacccagtctggctcagcaaggaggctgtcagcatcttgaaagct ttcatgacgaagaatccccacaagcgcctgggctgtgtggcatcgcagaatggcgaggac gccatcaagcagcacccattcttcaaagagattgactgggtgctcctggagcagaagaag atcaagccacccttcaaaccacgcattaaaaccaaaagagacgtcaataattttgaccaa gactttacccgggaagagccggtactcacccttgtggacgaagcaattgtaaagcagatc aaccaggaggaattcaaaggtttctcctactttggtgaagacctgatgccctga |
Protein Sequence |
>5581 : length: 737 MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI NQEEFKGFSYFGEDLMP |