General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
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Gene ID | 5581 |
Name | PRKCE |
Synonymous | protein kinase C, epsilon;PRKCE;protein kinase C, epsilon |
Definition | protein kinase C epsilon type |
Position | 2p21 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
Loss of Function mutations compare to missense mutations | Top |
The ratio of the loss-of-function mutations over missense mutations is 0.13. |
The copy number variations for various cancers | Top |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
---|---|---|---|
c.85G>A; p.V29M; 2:45652185-45652185 |
haematopoietic_and_lymphoid_tissue; central_nervous_system | lymphoid_neoplasm; primary_central_nervous_system_lymphoma | Substitution - Missense |
c.916C>A; p.L306M; 2:46001496-46001496 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.590A>C; p.Q197P; 2:45978993-45978993 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1512C>T; p.F504F; 2:46086282-46086282 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1512C>T; p.F504F; 2:46086282-46086282 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.485G>A; p.R162H; 2:45976501-45976501 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.485G>A; p.R162H; 2:45976501-45976501 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1479delC; p.L494fs*40; 2:46086249-46086249 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Deletion - Frameshift |
c.2105T>G; p.F702C; 2:46184772-46184772 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1399C>T; p.P467S; 2:46010479-46010479 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.898G>A; p.A300T; 2:46001478-46001478 |
breast | carcinoma; basal_(triple-negative)_carcinoma | Substitution - Missense |
c.898G>A; p.A300T; 2:46001478-46001478 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.123_124CA>AG; p.Y41_I42>*; 2:45652223-45652224 |
large_intestine; rectum | carcinoma; adenocarcinoma | Complex - deletion inframe |
c.1553C>T; p.S518L; 2:46086323-46086323 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1553C>T; p.S518L; 2:46086323-46086323 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1621G>A; p.D541N; 2:46145121-46145121 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1114C>T; p.R372*; 2:46007512-46007512 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.1504C>T; p.R502*; 2:46086274-46086274 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Nonsense |
c.1504C>T; p.R502*; 2:46086274-46086274 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Nonsense |
c.1504C>T; p.R502*; 2:46086274-46086274 |
skin | malignant_melanoma | Substitution - Nonsense |
c.2139C>T; p.D713D; 2:46184806-46184806 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2063G>T; p.R688L; 2:46159748-46159748 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.943A>G; p.N315D; 2:46001523-46001523 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.1914G>C; p.L638F; 2:46151223-46151223 |
ovary | other; neoplasm | Substitution - Missense |
c.230G>A; p.R77H; 2:45652330-45652330 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1014A>T; p.P338P; 2:46004589-46004589 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1438-1G>A; p.?; 2:46086207-46086207 |
breast | carcinoma | Unknown |
c.415C>T; p.P139S; 2:45976431-45976431 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.1130G>T; p.R377L; 2:46007528-46007528 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.79C>T; p.H27Y; 2:45652179-45652179 |
breast | carcinoma | Substitution - Missense |
c.2049A>C; p.P683P; 2:46159734-46159734 |
breast | carcinoma | Substitution - coding silent |
c.1297G>C; p.V433L; 2:46010377-46010377 |
ovary | other; neoplasm | Substitution - Missense |
c.478G>A; p.V160I; 2:45976494-45976494 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.2159T>A; p.I720N; 2:46184826-46184826 |
breast | carcinoma | Substitution - Missense |
c.1943A>C; p.K648T; 2:46159628-46159628 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1391G>A; p.R464Q; 2:46010471-46010471 |
skin | malignant_melanoma | Substitution - Missense |
c.1776C>T; p.A592A; 2:46151085-46151085 |
thyroid | other; neoplasm | Substitution - coding silent |
c.1310A>C; p.K437T; 2:46010390-46010390 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.277G>A; p.D93N; 2:45652377-45652377 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1064-10T>G; p.?; 2:46007452-46007452 |
oesophagus | carcinoma; adenocarcinoma | Unknown |
c.735C>T; p.F245F; 2:45984592-45984592 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.693G>T; p.Q231H; 2:45980381-45980381 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.695T>G; p.V232G; 2:45984552-45984552 |
breast | carcinoma | Substitution - Missense |
c.208G>A; p.V70I; 2:45652308-45652308 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1077T>C; p.L359L; 2:46007475-46007475 |
breast | carcinoma | Substitution - coding silent |
c.1974C>T; p.G658G; 2:46159659-46159659 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.419A>G; p.K140R; 2:45976435-45976435 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.419A>G; p.K140R; 2:45976435-45976435 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.20T>A; p.L7H; 2:45652120-45652120 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.483G>A; p.R161R; 2:45976499-45976499 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.1401G>A; p.P467P; 2:46010481-46010481 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1204C>T; p.R402C; 2:46007602-46007602 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.664G>T; p.G222W; 2:45980352-45980352 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia | Substitution - Missense |
c.2063G>A; p.R688H; 2:46159748-46159748 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.268G>C; p.G90R; 2:45652368-45652368 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.803G>A; p.R268Q; 2:45984660-45984660 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1701C>T; p.F567F; 2:46145201-46145201 |
skin | malignant_melanoma | Substitution - coding silent |
c.449G>A; p.R150H; 2:45976465-45976465 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.706C>A; p.R236R; 2:45984563-45984563 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.449G>A; p.R150H; 2:45976465-45976465 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1374G>A; p.R458R; 2:46010454-46010454 |
skin | malignant_melanoma | Substitution - coding silent |
c.639C>T; p.H213H; 2:45980327-45980327 |
breast | carcinoma | Substitution - coding silent |
c.99G>A; p.P33P; 2:45652199-45652199 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1188G>A; p.R396R; 2:46007586-46007586 |
breast | carcinoma | Substitution - coding silent |
c.237C>T; p.I79I; 2:45652337-45652337 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.504C>T; p.N168N; 2:45976520-45976520 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2068-1G>T; p.?; 2:46184734-46184734 |
endometrium | carcinoma; endometrioid_carcinoma | Unknown |
c.466C>G; p.R156G; 2:45976482-45976482 |
soft_tissue; blood_vessel | angiosarcoma | Substitution - Missense |
c.154G>A; p.G52S; 2:45652254-45652254 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.624C>T; p.V208V; 2:45980312-45980312 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.1805C>T; p.A602V; 2:46151114-46151114 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1263+8G>A; p.?; 2:46007669-46007669 |
liver | carcinoma | Unknown |
c.808G>C; p.G270R; 2:45984665-45984665 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1441C>A; p.R481S; 2:46086211-46086211 |
breast | carcinoma | Substitution - Missense |
c.1428C>G; p.F476L; 2:46010508-46010508 |
ovary | other; neoplasm | Substitution - Missense |
c.441C>T; p.F147F; 2:45976457-45976457 |
skin | malignant_melanoma | Substitution - coding silent |
c.1975G>C; p.E659Q; 2:46159660-46159660 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1653C>T; p.F551F; 2:46145153-46145153 |
breast | carcinoma | Substitution - coding silent |
c.2180G>T; p.G727V; 2:46184847-46184847 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1653C>T; p.F551F; 2:46145153-46145153 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.708G>A; p.R236R; 2:45984565-45984565 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.736G>A; p.G246S; 2:45984593-45984593 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.872A>G; p.N291S; 2:46001452-46001452 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.618C>T; p.C206C; 2:45980306-45980306 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.503A>T; p.N168I; 2:45976519-45976519 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.388G>A; p.D130N; 2:45843039-45843039 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1082A>C; p.N361T; 2:46007480-46007480 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.1453G>A; p.V485I; 2:46086223-46086223 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1453G>A; p.V485I; 2:46086223-46086223 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.1452C>T; p.F484F; 2:46086222-46086222 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.929C>T; p.P310L; 2:46001509-46001509 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.43G>A; p.A15T; 2:45652143-45652143 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.913G>A; p.D305N; 2:46001493-46001493 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.43G>A; p.A15T; 2:45652143-45652143 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1351G>T; p.D451Y; 2:46010431-46010431 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.687C>T; p.P229P; 2:45980375-45980375 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.687C>T; p.P229P; 2:45980375-45980375 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.1120G>A; p.E374K; 2:46007518-46007518 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1115G>A; p.R372Q; 2:46007513-46007513 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1964C>T; p.S655L; 2:46159649-46159649 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.697G>T; p.G233C; 2:45984554-45984554 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.843C>T; p.H281H; 2:46001423-46001423 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.71C>T; p.S24L; 2:45652171-45652171 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.254A>G; p.H85R; 2:45652354-45652354 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | Substitution - Missense |
c.2160C>T; p.I720I; 2:46184827-46184827 |
breast | carcinoma | Substitution - coding silent |
c.7G>C; p.V3L; 2:45652107-45652107 |
kidney | carcinoma; papillary_renal_cell_carcinoma | Substitution - Missense |
c.1841A>G; p.D614G; 2:46151150-46151150 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1818delC; p.F607fs*32; 2:46151127-46151127 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1327G>A; p.V443I; 2:46010407-46010407 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1789A>G; p.M597V; 2:46151098-46151098 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1795G>A; p.E599K; 2:46151104-46151104 |
skin | malignant_melanoma | Substitution - Missense |
c.1866C>T; p.D622D; 2:46151175-46151175 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1319A>G; p.K440R; 2:46010399-46010399 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1833T>C; p.N611N; 2:46151142-46151142 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.8T>C; p.V3A; 2:45652108-45652108 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1390C>T; p.R464W; 2:46010470-46010470 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.454C>T; p.R152W; 2:45976470-45976470 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.707G>A; p.R236Q; 2:45984564-45984564 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.404C>T; p.S135L; 2:45843055-45843055 |
breast | carcinoma | Substitution - Missense |
c.1373G>T; p.R458M; 2:46010453-46010453 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.1816delC; p.F607fs*32; 2:46151125-46151125 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.527A>G; p.Y176C; 2:45976543-45976543 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1027C>T; p.R343*; 2:46004602-46004602 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.1797G>A; p.E599E; 2:46151106-46151106 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.427G>A; p.E143K; 2:45976443-45976443 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.120C>T; p.P40P; 2:45652220-45652220 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1346A>T; p.D449V; 2:46010426-46010426 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.1513G>A; p.D505N; 2:46086283-46086283 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.1513G>A; p.D505N; 2:46086283-46086283 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.897C>T; p.I299I; 2:46001477-46001477 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |