| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5581 |
Name | PRKCE |
Synonymous | PKCE|nPKC-epsilon;protein kinase C, epsilon;PRKCE;protein kinase C, epsilon |
Definition | protein kinase C epsilon type |
Position | 2p21 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
PKCepsilon(h) + gja1(h) <==> PKCepsilon(h):gja1(h) (binding) | Bax(h) + PKCepsilon(h) <==> Bax(h):PKCepsilon(h) (binding) | PKCepsilon(h) + beta-actin(h) <==> PKCepsilon(h):beta-actin(h) (binding) | PKCepsilon(h) + 14-3-3beta(m.s.) <==> PKCepsilon(h):14-3-3beta(m.s.) (binding) | PKCepsilon(h) + ATP --> PKCepsilon(h){pS346} + ADP (phosphorylation) | PKCepsilon(h) + ATP --> PKCepsilon(h){pS729} + ADP (phosphorylation) | PKCepsilon(h) + ATP --> PKCepsilon(h){p} + ADP (phosphorylation) | PRKCE(h) --> PKCepsilon(h) (expression). | TNF-alpha(m.s.) --/ PKCepsilon(h) (decrease of abundance) | phlpp2(h) --/ PKCepsilon(h) (decrease of abundance) | phlpp1(h) --/ PKCepsilon(h) (decrease of abundance) | cTnI(b):cTnT(b):TNNC(b) + 2 ATP --PKCepsilon(h)--> cTnT(b){p}:cTnI(b){p}:TNNC(b) + 2 ADP (phosphorylation) | cTnI(b) + 2 ATP --PKCepsilon(h)--> cTnI(b){pS78}{pT144} + 2 ADP (phosphorylation) | cTnT(b) + 4 ATP --PKCepsilon(h)--> cTnT(b){pT190}{pS194}{pT199}{pT280} + 4 ADP (phosphorylation) | AKT-1(h) + PKCepsilon(h) <==> AKT-1(h):PKCepsilon(h) (binding) | eNOS(b) + PKCepsilon(h) <==> eNOS(b):PKCepsilon(h) (binding) | AKT-1(h) + eNOS(b) + PKCepsilon(h) <==> AKT-1(h):eNOS(b):PKCepsilon(h) (binding) | PRKCE(h) --> PKCepsilon(h) (expression). | CYP7(h) + ATP --PKCepsilon(h)--> CYP7(h){p} + ADP (phosphorylation) | GABA-AR-gamma2(m) + ATP --PKCepsilon(h)--> GABA-AR-gamma2(m){pS} + ADP (phosphorylation) | CLIC1(m.s.) + ATP --PKCepsilon(h)--> CLIC1(m.s.){p} + ADP (phosphorylation) | CLIC4(m.s.) + ATP --PKCepsilon(h)--> CLIC4(m.s.){p} + ADP (phosphorylation) | PRKCE(h) --> PRKCE(h) (expression). | hsa-miR-205 --/ PRKCE(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
337 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 349 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 566 | Phosphothreonine (by PDPK1). | Swiss-Prot 53.0 | 703 | Phosphothreonine (by autocatalysis)(Potential). | Swiss-Prot 53.0 | 710 | Phosphothreonine (by autocatalysis)(Potential). | Swiss-Prot 53.0 | 729 | Phosphoserine (by autocatalysis). | Swiss-Prot 53.0 | 566 | Phosphothreonine (PDK-1) | 11062054;12640464;11964154 | Phospho.ELM 6.0 | 710 | Phosphothreonine | 12640464 | Phospho.ELM 6.0 | 729 | Phosphoserine (PKC epsilon) | 11062054;12640464;11964154 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 45731047 - 45733047 | Agilent_014791 |
chr2 |
Promoter: 45731047 - 45733047 | GSE27584 |