| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5770 |
Name | PTPN1 |
Synonym | PTP1B;protein tyrosine phosphatase, non-receptor type 1;PTPN1;protein tyrosine phosphatase, non-receptor type 1 |
Definition | protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1 |
Position | 20q13.1-q13.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 13591 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Integrin alphaIIbbeta3 signaling;PID Reactome;500005 |
Disease | Hypertension;FunDO |
Disease | body fat;GAD |
Disease | atherosclerosis, diabetic;GAD |
Disease | Prostate cancer;FunDO |
Disease | diabetes or impaired glucose tolerance;GAD |
Disease | type 1 diabetes;GAD |
Disease | IMMUNE;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | obesity;GAD |
Disease | Insulin resistance, susceptibility to;OMIM |
Disease | anthropometric parameters diabetes, type 2 insulin;GAD |
Disease | diabetes, type 2;GAD |
Disease | METABOLIC;GAD |
Disease | diabetes, type 2 glucose insulin obesity;GAD |
Disease | insulin;GAD |
Disease | Breast cancer;FunDO |
Disease | Colon cancer;FunDO |
Disease | glucose tolerance;GAD |
Disease | Metabolism disease;FunDO |
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External Links |
|
Links to Entrez Gene | 5770 |
Links to all GeneRIF Items | 5770 |
Links to iHOP | 5770 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5770 : length: 1308 atggagatggaaaaggagttcgagcagatcgacaagtccgggagctgggcggccatttac caggatatccgacatgaagccagtgacttcccatgtagagtggccaagcttcctaagaac aaaaaccgaaataggtacagagacgtcagtccctttgaccatagtcggattaaactacat caagaagataatgactatatcaacgctagtttgataaaaatggaagaagcccaaaggagt tacattcttacccagggccctttgcctaacacatgcggtcacttttgggagatggtgtgg gagcagaaaagcaggggtgtcgtcatgctcaacagagtgatggagaaaggttcgttaaaa tgcgcacaatactggccacaaaaagaagaaaaagagatgatctttgaagacacaaatttg aaattaacattgatctctgaagatatcaagtcatattatacagtgcgacagctagaattg gaaaaccttacaacccaagaaactcgagagatcttacatttccactataccacatggcct gactttggagtccctgaatcaccagcctcattcttgaactttcttttcaaagtccgagag tcagggtcactcagcccggagcacgggcccgttgtggtgcactgcagtgcaggcatcggc aggtctggaaccttctgtctggctgatacctgcctcttgctgatggacaagaggaaagac ccttcttccgttgatatcaagaaagtgctgttagaaatgaggaagtttcggatggggctg atccagacagccgaccagctgcgcttctcctacctggctgtgatcgaaggtgccaaattc atcatgggggactcttccgtgcaggatcagtggaaggagctttcccacgaggacctggag cccccacccgagcatatccccccacctccccggccacccaaacgaatcctggagccacac aatgggaaatgcagggagttcttcccaaatcaccagtgggtgaaggaagagacccaggag gataaagactgccccatcaaggaagaaaaaggaagccccttaaatgccgcaccctacggc atcgaaagcatgagtcaagacactgaagttagaagtcgggtcgtggggggaagtcttcga ggtgcccaggctgcctccccagccaaaggggagccgtcactgcccgagaaggacgaggac catgcactgagttactggaagcccttcctggtcaacatgtgcgtggctacggtcctcacg gccggcgcttacctctgctacaggttcctgttcaacagcaacacatag |
Protein Sequence |
>5770 : length: 435 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT AGAYLCYRFLFNSNT |