| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5781 |
Name | PTPN11 |
Synonym | BPTP3|CFC|NS1|PTP-1D|PTP2C|SH-PTP2|SH-PTP3|SHP2;protein tyrosine phosphatase, non-receptor type 11;PTPN11;protein tyrosine phosphatase, non-receptor type 11 |
Definition | PTP-2C|protein-tyrosine phosphatase 1D|protein-tyrosine phosphatase 2C|tyrosine-protein phosphatase non-receptor type 11 |
Position | 12q24 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 13592 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
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Pathways and Diseases |
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Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | igf-1 signaling pathway;PID BioCarta;100136 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Interferon-gamma signaling pathway;PANTHER;P00035 |
Pathway | insulin signaling pathway;PID BioCarta;100124 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | CTLA4 inhibitory signaling;PID Reactome;500487 |
Pathway | IL2 signaling events mediated by STAT5;PID Curated;200158 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Down-stream signal transduction;PID Reactome;500509 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Netrin mediated repulsion signals;PID Reactome;500090 |
Pathway | cell to cell adhesion signaling;PID BioCarta;100208 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | the co-stimulatory signal during t-cell activation;PID BioCarta;100193 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Gab1 signalosome;PID Reactome;500514 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | FRS2-mediated cascade;PID Reactome;500248 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | PECAM1 interactions;PID Reactome;500307 |
Pathway | il 6 signaling pathway;PID BioCarta;100126 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Tie2 Signaling;PID Reactome;500306 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Type 1 diabetes;NHGRI |
Disease | gastric atrophy;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | Hematological parameters;NHGRI |
Disease | Congenital heart disease;FunDO |
Disease | Skin disease, Genetic;FunDO |
Disease | Leukemia, Myeloid, Acute;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | Herpes;FunDO |
Disease | heart anomalies, congenital;GAD |
Disease | stomach atrophy;GAD |
Disease | Leukemia;FunDO |
Disease | IMMUNE;GAD |
Disease | Infection;FunDO |
Disease | Leukemia, juvenile myelomonocytic;OMIM |
Disease | hematological parameters;GAD |
Disease | METABOLIC;GAD |
Disease | Noonan-like/multiple giant cell lesion syndrome;OMIM |
Disease | Leopard syndrome;OMIM |
Disease | Noonan syndrome;GAD |
Disease | Lymphoproliferative disorder;FunDO |
Disease | Solid tumor;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Noonan syndrome 1;OMIM |
Disease | CANCER;GAD |
Disease | Deafness;FunDO |
Disease | plasma HDL cholesterol (HDL-C) levels;GAD |
Disease | Brain tumor;FunDO |
Disease | Hemorrhagic disorder;FunDO |
Disease | Myeloproliferative disease;FunDO |
Disease | leukemia;GAD |
Disease | type 1 diabetes;GAD |
Disease | Skin cancer;FunDO |
Disease | stomach cancer;GAD |
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External Links |
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Links to Entrez Gene | 5781 |
Links to all GeneRIF Items | 5781 |
Links to iHOP | 5781 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5781 : length: 1782 atgacatcgcggagatggtttcacccaaatatcactggtgtggaggcagaaaacctactg ttgacaagaggagttgatggcagttttttggcaaggcctagtaaaagtaaccctggagac ttcacactttccgttagaagaaatggagctgtcacccacatcaagattcagaacactggt gattactatgacctgtatggaggggagaaatttgccactttggctgagttggtccagtat tacatggaacatcacgggcaattaaaagagaagaatggagatgtcattgagcttaaatat cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacatctctctgggaaa gaagcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagc cagagccaccctggagattttgttctttctgtgcgcactggtgatgacaaaggggagagc aatgacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatacgac gttggtggaggagaacggtttgattctttgacagatcttgtggaacattataagaagaat cctatggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgt ataaatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccaca gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa cttctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaa aacatcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcct gtttcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaat tcaaagcccaaaaagagttacattgccacacaaggctgcctgcaaaacacggtgaatgac ttttggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtg gagagaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatat ggcgtcatgcgtgttaggaacgtcaaagaaagcgccgctcatgactatacgctaagagaa cttaaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccacttt cggacctggccggaccacggcgtgcccagcgaccctgggggcgtgctggacttcctggag gaggtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagt gctggaattggccggacagggacgttcattgtgattgatattcttattgacatcatcaga gagaaaggtgttgactgcgatattgacgttcccaaaaccatccagatggtgcggtctcag aggtcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcat tatattgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcac gaatatacaaatattaagtattctctagcggaccagacgagtggagatcagagccctctc ccgccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctat gaaaacgtgggcctgatgcaacagcagaaaagtttcagatga |
Protein Sequence |
>5781 : length: 593 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR |