| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5788 |
Name | PTPRC |
Synonym | B220|CD45|CD45R|GP180|L-CA|LCA|LY5|T200;protein tyrosine phosphatase, receptor type, C;PTPRC;protein tyrosine phosphatase, receptor type, C |
Definition | CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase, receptor type, c polypeptide|receptor-type tyrosine-protein phosphatase C |
Position | 1q31-q32 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 13605 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | lck and fyn tyrosine kinases in initiation of tcr activation;PID BioCarta;100023 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | Phosphorylation of CD3 and TCR zeta chains;PID Reactome;500479 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | JAK/STAT signaling pathway;PANTHER;P00038 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | Sema4D in semaphorin signaling;PID Reactome;500072 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Disease | IMMUNE;GAD |
Disease | paraparesis;GAD |
Disease | Multiple myeloma;FunDO |
Disease | T-B+ Severe combined immunodeficiencies;KEGG DISEASE;H00091 |
Disease | HTLV-1 associated myelopathy/tropical spastic;GAD |
Disease | HIV infection;FunDO |
Disease | abnormal splicing;GAD |
Disease | sclerosis, systemic;GAD |
Disease | Systemic scleroderma;FunDO |
Disease | Hepatitic C virus, susceptibility to;OMIM |
Disease | Systemic infection;FunDO |
Disease | lupus erythematosus;GAD |
Disease | INFECTION;GAD |
Disease | Colon cancer;FunDO |
Disease | Severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive;OMIM |
Disease | Autoimmune disease;FunDO |
Disease | systemic sclerosis;GAD |
Disease | Fetal disease;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | multiple sclerosis;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Congenital abnormality;FunDO |
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External Links |
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Links to Entrez Gene | 5788 |
Links to all GeneRIF Items | 5788 |
Links to iHOP | 5788 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5788 : length: 3915 atgtatttgtggcttaaactcttggcatttggctttgcctttctggacacagaagtattt gtgacagggcaaagcccaacaccttcccccactggattgactacagcaaagatgcccagt gttccactttcaagtgaccccttacctactcacaccactgcattctcacccgcaagcacc tttgaaagagaaaatgacttctcagagaccacaacttctcttagtccagacaatacttcc acccaagtatccccggactctttggataatgctagtgcttttaataccacaggtgtttca tcagtacagacgcctcaccttcccacgcacgcagactcgcagacgccctctgctggaact gacacgcagacattcagcggctccgccgccaatgcaaaactcaaccctaccccaggcagc aatgctatctcagatgtcccaggagagaggagtacagccagcacctttcctacagaccca gtttccccattgacaaccaccctcagccttgcacaccacagctctgctgccttacctgca cgcacctccaacaccaccatcacagcgaacacctcagatgcctaccttaatgcctctgaa acaaccactctgagcccttctggaagcgctgtcatttcaaccacaacaatagctactact ccatctaagccaacatgtgatgaaaaatatgcaaacatcactgtggattacttatataac aaggaaactaaattatttacagcaaagctaaatgttaatgagaatgtggaatgtggaaac aatacttgcacaaacaatgaggtgcataaccttacagaatgtaaaaatgcgtctgtttcc atatctcataattcatgtactgctcctgataagacattaatattagatgtgccaccaggg gttgaaaagtttcagttacatgattgtacacaagttgaaaaagcagatactactatttgt ttaaaatggaaaaatattgaaacctttacttgtgatacacagaatattacctacagattt cagtgtggtaatatgatatttgataataaagaaattaaattagaaaaccttgaacccgaa catgagtataagtgtgactcagaaatactctataataaccacaagtttactaacgcaagt aaaattattaaaacagattttgggagtccaggagagcctcagattattttttgtagaagt gaagctgcacatcaaggagtaattacctggaatccccctcaaagatcatttcataatttt accctctgttatataaaagagacagaaaaagattgcctcaatctggataaaaacctgatc aaatatgatttgcaaaatttaaaaccttatacgaaatatgttttatcattacatgcctac atcattgcaaaagtgcaacgtaatggaagtgctgcaatgtgtcatttcacaactaaaagt gctcctccaagccaggtctggaacatgactgtctccatgacatcagataatagtatgcat gtcaagtgtaggcctcccagggaccgtaatggcccccatgaacgttaccatttggaagtt gaagctggaaatactctggttagaaatgagtcgcataagaattgcgatttccgtgtaaaa gatcttcaatattcaacagactacacttttaaggcctattttcacaatggagactatcct ggagaaccctttattttacatcattcaacatcttataattctaaggcactgatagcattt ctggcatttctgattattgtgacatcaatagccctgcttgttgttctctacaaaatctat gatctacataagaaaagatcctgcaatttagatgaacagcaggagcttgttgaaagggat gatgaaaaacaactgatgaatgtggagccaatccatgcagatattttgttggaaacttat aagaggaagattgctgatgaaggaagactttttctggctgaatttcagagcatcccgcgg gtgttcagcaagtttcctataaaggaagctcgaaagccctttaaccagaataaaaaccgt tatgttgacattcttccttatgattataaccgtgttgaactctctgagataaacggagat gcagggtcaaactacataaatgccagctatattgatggtttcaaagaacccaggaaatac attgctgcacaaggtcccagggatgaaactgttgatgatttctggaggatgatttgggaa cagaaagccacagttattgtcatggtcactcgatgtgaagaaggaaacaggaacaagtgt gcagaatactggccgtcaatggaagagggcactcgggcttttggagatgttgttgtaaag atcaaccagcacaaaagatgtccagattacatcattcagaaattgaacattgtaaataaa aaagaaaaagcaactggaagagaggtgactcacattcagttcaccagctggccagaccac ggggtgcctgaggatcctcacttgctcctcaaactgagaaggagagtgaatgccttcagc aatttcttcagtggtcccattgtggtgcactgcagtgctggtgttgggcgcacaggaacc tatatcggaattgatgccatgctagaaggcctggaagccgagaacaaagtggatgtttat ggttatgttgtcaagctaaggcgacagagatgcctgatggttcaagtagaggcccagtac atcttgatccatcaggctttggtggaatacaatcagtttggagaaacagaagtgaatttg tctgaattacatccatatctacataacatgaagaaaagggatccacccagtgagccgtct ccactagaggctgaattccagagacttccttcatataggagctggaggacacagcacatt ggaaatcaagaagaaaataaaagtaaaaacaggaattctaatgtcatcccatatgactat aacagagtgccacttaaacatgagctggaaatgagtaaagagagtgagcatgattcagat gaatcctctgatgatgacagtgattcagaggaaccaagcaaatacatcaatgcatctttt ataatgagctactggaaacctgaagtgatgattgctgctcagggaccactgaaggagacc attggtgacttttggcagatgatcttccaaagaaaagtcaaagttattgttatgctgaca gaactgaaacatggagaccaggaaatctgtgctcagtactggggagaaggaaagcaaaca tatggagatattgaagttgacctgaaagacacagacaaatcttcaacttatacccttcgt gtctttgaactgagacattccaagaggaaagactctcgaactgtgtaccagtaccaatat acaaactggagtgtggagcagcttcctgcagaacccaaggaattaatctctatgattcag gtcgtcaaacaaaaacttccccagaagaattcctctgaagggaacaagcatcacaagagt acacctctactcattcactgcagggatggatctcagcaaacgggaatattttgtgctttg ttaaatctcttagaaagtgcggaaacagaagaggtagtggatatttttcaagtggtaaaa gctctacgcaaagctaggccaggcatggtttccacattcgagcaatatcaattcctatat gacgtcattgccagcacctaccctgctcagaatggacaagtaaagaaaaacaaccatcaa gaagataaaattgaatttgataatgaagtggacaaagtaaagcaggatgctaattgtgtt aatccacttggtgccccagaaaagctccctgaagcaaaggaacaggctgaaggttctgaa cccacgagtggcactgaggggccagaacattctgtcaatggtcctgcaagtccagcttta aatcaaggttcatag |
Protein Sequence |
>5788 : length: 1304 MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT DTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPA RTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYN KETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPG VEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPE HEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNF TLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKS APPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVK DLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIY DLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPR VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKY IAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVK INQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQY ILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS |