| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 6502 |
Name | SKP2 |
Synonym | FBL1|FBXL1|FLB1|p45;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase;SKP2;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
Definition | CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2 |
Position | 5p13 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 14986 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | e2f1 destruction pathway;PID BioCarta;100034 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Notch signaling pathway;PID Curated;200013 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | C-MYC pathway;PID Curated;200093 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | regulation of p27 phosphorylation during cell cycle progression;PID BioCarta;100087 |
Disease | Cancer;FunDO |
Disease | Skin disease;FunDO |
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External Links |
|
Links to Entrez Gene | 6502 |
Links to all GeneRIF Items | 6502 |
Links to iHOP | 6502 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>6502 : length: 1275 atgcacaggaagcacctccaggagattccagacctgagtagcaacgttgccaccagcttc acgtggggatgggattccagcaagacttctgaactgctgtcaggcatgggggtctccgcc ctggagaaagaggagcccgacagtgagaacatcccccaggaactgctctcaaacctgggc cacccggagagccccccacggaaacggctgaagagcaaagggagtgacaaagactttgtg attgtccgcaggcctaagctaaatcgagagaactttccaggtgtttcatgggactccctt ccggatgagctgctcttgggaatcttttcctgtctgtgcctccctgagctgctaaaggtc tctggtgtttgtaagaggtggtatcgcctagcgtctgatgagtctctatggcagacctta gacctcacaggtaaaaatctgcacccggatgtgactggtcggttgctgtctcaaggggtg attgccttccgctgcccacgatcatttatggaccaaccattggctgaacatttcagccct tttcgtgtacagcacatggacctatcgaactcagttatagaagtgtccaccctccacggc atactgtctcagtgttccaagttgcagaatctaagcctggaaggcctgcggctttcggat cccattgtcaatactctcgcaaaaaactcaaatttagtgcgacttaacctttctgggtgt tctggattctctgaatttgccctgcagactttgctaagcagctgttccagactggatgag ctgaacctctcctggtgttttgatttcactgaaaagcatgtacaggtggctgttgcgcat gtgtcagagaccatcacccagctgaatcttagcggctacagaaagaatctccagaaatca gatctctctactttagttagaagatgccccaatcttgtccatctagacttaagtgatagt gtcatgctaaagaatgactgctttcaggaatttttccagctcaactacctccaacaccta tcactcagtcggtgctatgatataatacctgaaactttacttgaacttggagaaattccc acactaaaaacactacaagtttttggaatcgtgccagatggtacccttcaactgttaaag gaagcccttcctcatctacagattaattgctcccatttcaccaccattgccaggccaact attggcaacaaaaagaaccaggagatatggggcatcaaatgccgactgacactgcaaaag cccagttgtctatga |
Protein Sequence |
>6502 : length: 424 MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLG HPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKV SGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSP FRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGC SGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKS DLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIP TLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQK PSCL |