| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 6502 |
Name | SKP2 |
Synonymous | FBL1|FBXL1|FLB1|p45;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase;SKP2;S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
Definition | CDK2/cyclin A-associated protein p45|F-box/LRR-repeat protein 1|S-phase kinase-associated protein 2|S-phase kinase-associated protein 2 (p45)|p45skp2 |
Position | 5p13 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
Cks1(h) + Skp2(h) <==> Cks1(h):Skp2(h) (binding) | cyclinE(h) + Skp2(h) <==> cyclinE(h):Skp2(h) (binding) | p27Kip1(h){pS10}{pT187}{pT198} + Skp2(h) <==> p27Kip1(h){pS10}{pT187}{pT198}:Skp2(h) (binding) | Fzr(h) + Skp2(h) <==> Fzr(h):Skp2(h) (binding) | Skp2(h) + n ubiquitin(v.s.) --E1(v.s.),E2-C(h),cyclosome(x):Fzr(h)--> Skp2(h){ub(n)} (ubiquitination) | Skp2(h) + Wee1(h) <==> Skp2(h):Wee1(h) (binding) | Skp1(h) + Skp2(h) <==> Skp1(h):Skp2(h) (binding) | cyclinA(h):Cdk2(h) + Skp2(h) <==> cyclinA(h):Cdk2(h):Skp2(h) (binding) | Skp2(h) + ATP --cyclinA(b):Cdk2(x){pT160}--> Skp2(h){pS76} + ADP (phosphorylation) | cyclinA(h) + Skp2(h) <==> cyclinA(h):Skp2(h) (binding) | E47(h){p} + Skp2(h) <==> E47(h){p}:Skp2(h) (binding) | Skp2(h) + Skp1(h) + E47(h) <==> Skp2(h):Skp1(h):E47(h) (binding) | p27Kip1(h) + Skp2(h) <==> p27Kip1(h):Skp2(h) (binding) | c-Myc(h) + Skp2(h) <==> c-Myc(h):Skp2(h) (binding) | FOXO1A(h) + Skp2(h) <==> FOXO1A(h):Skp2(h) (binding) | Skp2(h) + FOXO1A(m.s.) <==> Skp2(h):FOXO1A(m.s.) (binding) | BRCA2(h) + Skp2(h) <==> BRCA2(h):Skp2(h) (binding) | Skp2(h) --> protein remnants (degradation) | Tob1(h) + Skp2(h) <==> Tob1(h):Skp2(h) (binding) | Skp2(h) --/ p27Kip1(h) (decrease of abundance) | Skp2(h) + CUL4A(m.s.) <==> Skp2(h):CUL4A(m.s.) (binding) | Skp2(h) --> p53(h){aceK382} (decrease of acetylation) | Skp2(h) + p300(h) <==> Skp2(h):p300(h) (binding) | Skp2(h) + p300(m.s.) <==> Skp2(h):p300(m.s.) (binding) | AKT-1(m.s.) + Skp2(h) <==> AKT-1(m.s.):Skp2(h) (binding) | Skp2(h) + ATP --AKT-1(m.s.)--> Skp2(h){pS72} + ADP (phosphorylation) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){p} + ADP (phosphorylation) | Skp2(h) + ATP --AKT-2(m)--> Skp2(h){pS72} + ADP (phosphorylation) | CKI-epsilon(h) + Skp2(h) <==> CKI-epsilon(h):Skp2(h) (binding) | Skp2(h) + CKI-delta(h) <==> Skp2(h):CKI-delta(h) (binding) | Skp2(h) + ATP --CKI(h)--> Skp2(h){pS75} + ADP (phosphorylation) | Skp2(h) + ATP --> Skp2(h){pS64} + ADP (phosphorylation) | Skp2(h) + 2 ATP --> Skp2(h){pS72}{pS75} + 2 ADP (phosphorylation) | Skp2(h) + Fzr1(m.s.) <==> Skp2(h):Fzr1(m.s.) (binding) | Skp2(h) + importin-alpha(m.s.) <==> Skp2(h):importin-alpha(m.s.) (binding) | Skp2(h) --> Skp2(h) (translocation) | AKT-1(h) + Skp2(h) <==> AKT-1(h):Skp2(h) (binding) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){pS72} + ADP (phosphorylation) | 14-3-3beta(h) + Skp2(h) <==> 14-3-3beta(h):Skp2(h) (binding) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){pT21} + ADP (phosphorylation) | Twa1(h) + Skp2(h) <==> Twa1(h):Skp2(h) (binding) | SKP2(h) --> Skp2(h) (expression). | HDAC(h) --/ Skp2(h) (decrease of abundance) | AKT-1(h){pS473} --> Skp2(h) (increase of abundance) | AKT-1(h) --> Skp2(h) (increase of abundance) | PTEN(h) --/ Skp2(h) (decrease of abundance) | IGF-1(h) --> Skp2(h) (increase of abundance) | Fzr(h) --/ Skp2(h) (decrease of abundance) | CKI(h) --> Skp2(h) (increase of abundance) | Skp2(h) --> Skp2(h) (translocation) | DDB1(h) --/ Skp2(h) (decrease of abundance) | E-cadherin(h) --/ Skp2(h) (decrease of abundance) | BRCA2(h) + ubiquitin(h) --Skp2(h)--> BRCA2(h){ub} (ubiquitination) | Cdk2(h) + ATP --CAK(m)--> Cdk2(h){pT160} + ADP (phosphorylation) | Cdk2(h) + ATP --Wee1(h)--> Cdk2(h){pY15} + ADP (phosphorylation) | Cul-1(h) + Skp1(h) + Skp2-alpha(h) <==> Cul-1(h):Skp1(h):Skp2-alpha(h) (binding) | SKP2(h) --> Skp2-alpha(h) (expression). | SKP2(h) --> Skp2-beta(h) (expression). | SKP2(h) --> skp2-gamma(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
64 | Phosphoserine. | Swiss-Prot 53.0 | 64 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr5 |
Promoter: 36186446 - 36188446 | GSE27584 |
chr5 |
Promoter: 36186446 - 36188446 | GSE27584 |