| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6688 |
Name | SPI1 |
Synonym | OF|PU.1|SFPI1|SPI-1|SPI-A;Spi-1 proto-oncogene;SPI1;Spi-1 proto-oncogene |
Definition | 31 kDa transforming protein|31 kDa-transforming protein|hematopoietic transcription factor PU.1|spleen focus forming virus (SFFV) proviral integration oncogene spi1|transcription factor PU.1 |
Position | 11p11.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 15658 |
TUSON P-value | 1 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Acute myeloid leukemia (AML);KEGG DISEASE;H00003 |
Disease | Leukoencephalopathy;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | Lymphoma;FunDO |
|
External Links |
|
Links to Entrez Gene | 6688 |
Links to all GeneRIF Items | 6688 |
Links to iHOP | 6688 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>6688 : length: 816 atgttacaggcgtgcaaaatggaagggtttcccctcgtcccccctcagccatcagaagac ctggtgccctatgacacggatctataccaacgccaaacgcacgagtattacccctatctc agcagtgatggggagagccatagcgaccattactgggacttccacccccaccacgtgcac agcgagttcgagagcttcgccgagaacaacttcacggagctccagagcgtgcagcccccg cagctgcagcagctctaccgccacatggagctggagcagatgcacgtcctcgataccccc atggtgccaccccatcccagtcttggccaccaggtctcctacctgccccggatgtgcctc cagtacccatccctgtccccagcccagcccagctcagatgaggaggagggcgagcggcag agccccccactggaggtgtctgacggcgaggcggatggcctggagcccgggcctgggctc ctgcctggggagacaggcagcaagaagaagatccgcctgtaccagttcctgttggacctg ctccgcagcggcgacatgaaggacagcatctggtgggtggacaaggacaagggcaccttc cagttctcgtccaagcacaaggaggcgctggcgcaccgctggggcatccagaagggcaac cgcaagaagatgacctaccagaagatggcgcgcgcgctgcgcaactacggcaagacgggc gaggtcaagaaggtgaagaagaagctcacctaccagttcagcggcgaagtgctgggccgc gggggcctggccgagcggcgccacccgccccactga |
Protein Sequence |
>6688 : length: 271 MLQACKMEGFPLVPPQPSEDLVPYDTDLYQRQTHEYYPYLSSDGESHSDHYWDFHPHHVH SEFESFAENNFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHPSLGHQVSYLPRMCL QYPSLSPAQPSSDEEEGERQSPPLEVSDGEADGLEPGPGLLPGETGSKKKIRLYQFLLDL LRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTG EVKKVKKKLTYQFSGEVLGRGGLAERRHPPH |