Entrez Gene

Basic Information
Gene ID	6688
Name	SPI1
Synonymous	OF\|PU.1\|SFPI1\|SPI-1\|SPI-A;Spi-1 proto-oncogene;SPI1;Spi-1 proto-oncogene
Definition	31 kDa transforming protein\|31 kDa-transforming protein\|hematopoietic transcription factor PU.1\|spleen focus forming virus (SFFV) proviral integration oncogene spi1\|transcription factor PU.1
Position	11p11.2
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
SPI1(h) + TBP(m) <==> SPI1(h):TBP(m) (binding).
SPI1(h) + TBP(d) <==> SPI1(h):TBP(d) (binding).
SPI1(h) + pRb(h) <==> SPI1(h):pRb(h) (binding).
TBP(h) + SPI1(h) <==> TBP(h):SPI1(h) (binding).
IRF-4(m) + SPI1(h) <==> IRF-4(m):SPI1(h) (binding).
SPI1(h) --> ITGA2B(h) (DNA binding).
SPI1(h) --> IgH(m) (DNA binding).
SPI1(h) --> Ig-kappa(m) (DNA binding).
SPI1(h) --> ISG15(h) (DNA binding).
SPI1(h) --> I-Abeta(m) (DNA binding; transregulation).
SPI1(h) --> MSV(MSV) (DNA binding).
SPI1(h) --> SV40(sv) (DNA binding).
SPI1(h) --> E74(d) (DNA binding).
SPI1(h) --> Cd79a(m) (DNA binding).
SPI1(h) --> ITGAM(h) (DNA binding).
SPI1(h) --> NCF4(h) (DNA binding; transactivation).
SPI1(h) --> Sfpi1(m) (DNA binding; transactivation).
SPI1(h) --> F-MuLV(FMULV) (DNA binding).
SPI1(h) --> IL1B(h) (DNA binding; transactivation).
SPI1(h) --> Ela2a(m) (DNA binding; transregulation).
SPI1(h) --> IL12B(h) (DNA binding; transactivation).
SPI1(h) --> FES(h) (transactivation)
SPI1(h) --> TNFSF10(h) (DNA binding; transactivation).
SPI1(h) --> PRTN3(h) (DNA binding).
SPI1(h) --> SPI1(h) (expression).
GATA-2(m) + SPI1(h) <==> GATA-2(m):SPI1(h) (binding)
GATA-2(h) + SPI1(h) <==> GATA-2(h):SPI1(h) (binding)
SPI1(h) + GATA-1(m.s.) <==> SPI1(h):GATA-1(m.s.) (binding)
GATA-1(h) + SPI1(h) <==> GATA-1(h):SPI1(h) (binding)
c-Jun(m.s.) + SPI1(h) <==> c-Jun(m.s.):SPI1(h) (binding)
SPI1(h) --> Ela2(m) (DNA binding).
SPI1(h) --> CYBB(h) (DNA binding).
SPI1(h) --> CSF2RA(h) (DNA binding).
SPI1(h) --> ITGB2(h) (DNA binding).
SPI1(h) --> IL1B(h) (DNA binding).
SPI1(h) --> CSF1R(h) (DNA binding).
SPI1(h) --> NCF1(h) (DNA binding; transactivation).
SPI1(h) --> ERBB2(h) (DNA binding).
SPI1(h) --> PTPN6(h) (DNA binding).
SPI1(h) --> FES(h) (DNA binding; transactivation).
SPI1(h) --> TAL1(h) (DNA binding).
SPI1(h) --> ETS2(h) (DNA binding).
SPI1(h) --> FLI1(m) (DNA binding).
SPI1(h) --> FCER1A(h) (DNA binding).
SPI1(h) --> IRF4(h) (DNA binding).
SPI1(h) --> CD68(h) (DNA binding).
SPI1(h) --> MIRN424(h) (DNA binding).
SPI1(h) --> CAMP(h) (DNA binding).
SPI1(h) --> GP6(h) (DNA binding).
SPI1(h) --> DEFA1(h) (DNA binding).
SPI1(h) --> CHI3L1(h) (DNA binding).
SPI1(h) --> Ig-lambda(m) (DNA binding).
SPI1(h) --> TLR4(h) (DNA binding).
SPI1(h) --> Tnf(m) (DNA binding).
SPI1(h) --> ITGAM(h) (DNA binding).
SPI1(h) --> Prtn3(m) (DNA binding).
SPI1(h) --> ZNF202(h) (DNA binding).
SPI1(h) --> PRTN3(h) (DNA binding).
SPI1(h) --> SPI1(h) (expression).
SPI1(h) --> SPI1(h) (expression).
hsa-miR-155 --/ SPI1(h) (translational repression).

Post Transcriptional Modification [Top]
	There is no record for SPI1

Chromosome	Location	Source
Methylation Profile [Top]
chr11	Promoter: 47356203 - 47358203	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 47356203 - 47358203	GoldenGate_Methylation_Cancer_Panel_I
chr11	Promoter: 47356203 - 47358203	GSE27584
chr11	Promoter: 47356203 - 47358203	GSE27584
chr11	Promoter: 47356203 - 47358203	PMID:16304050
chr11	Promoter: 47356203 - 47358203	PMID:16304050

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]