| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6934 |
Name | TCF7L2 |
Synonym | TCF-4|TCF4;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box) |
Definition | HMG box transcription factor 4|T-cell factor 4|T-cell factor-4 variant A|T-cell factor-4 variant B|T-cell factor-4 variant C|T-cell factor-4 variant D|T-cell factor-4 variant E|T-cell factor-4 variant F|T-cell factor-4 variant G|T-cell factor-4 variant H| |
Position | 10q25.3 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 122 |
TUSON P-value | 6.46E-05 |
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Pathways and Diseases |
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Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC);KEGG PATHWAY;hsa05412 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | AP-1 transcription factor network;PID Curated;200118 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Type 2 diabetes;NHGRI |
Disease | fasting glucose-related traits;GAD |
Disease | diabetes, gestational;GAD |
Disease | body mass insulin;GAD |
Disease | clinicopathological characteristics of hepatocellular carcinoma;GAD |
Disease | Diabetes;KEGG DISEASE |
Disease | type 2 diabetes;GAD |
Disease | Posttransplantation diabetes mellitus (PTDM);GAD |
Disease | Two-hour glucose challenge;NHGRI |
Disease | METABOLIC;GAD |
Disease | Type 2 diabetes and other traits;NHGRI |
Disease | Metabolic syndrome;NHGRI |
Disease | Glycated hemoglobin levels;NHGRI |
Disease | Diabetes mellitus, type 2, susceptibility to;OMIM |
Disease | diabetes, type 2;GAD |
Disease | Fasting glucose-related traits;NHGRI |
Disease | Coronary Artery Disease;GAD |
Disease | diabetes, type 2 glucose insulin;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | type 2 diabetes and other traits;GAD |
Disease | two-hour glucose challenge;GAD |
Disease | Metabolic diseases;KEGG DISEASE |
Disease | body mass cholesterol, HDL diabetes, type 2 glucose insulin metabolic syndrome triglycerides;GAD |
Disease | Type II diabetes mellitus;KEGG DISEASE;H00409 |
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External Links |
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Links to Entrez Gene | 6934 |
Links to all GeneRIF Items | 6934 |
Links to iHOP | 6934 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>6934 : length: 1809 atgccgcagctgaacggcggtggaggggatgacctaggcgccaacgacgaactgatttcc ttcaaagacgagggcgaacaggaggagaagagctccgaaaactcctcggcagagagggat ttagctgatgtcaaatcgtctctagtcaatgaatcagaaacgaatcaaaacagctcctcc gattccgaggcggaaagacggcctccgcctcgctccgaaagtttccgagacaaatcccgg gaaagtttggaagaagcggccaagaggcaagatggagggctctttaaggggccaccgtat cccggctaccccttcatcatgatccccgacctgacgagcccctacctccccaacggatcg ctctcgcccaccgcccgaaccctccattttcagtccggcagcacacattactctgcgtac aaaacgattgaacaccagattgcagttcagtatctccagatgaaatggccactgcttgat gtccaggcagggagcctccagagtagacaagccctcaaggatgcccggtccccatcaccg gcacacattgtctctaacaaagtgccagtggtgcagcaccctcaccatgtccaccccctc acgcctcttatcacgtacagcaatgaacacttcacgccgggaaacccacctccacactta ccagccgacgtagaccccaaaacaggaatcccacggcctccgcaccctccagatatatcc ccgtattacccactatcgcctggcaccgtaggacaaatcccccatccgctaggatggtta gtaccacagcaaggtcaaccagtgtacccaatcacgacaggaggattcagacacccctac cccacagctctgaccgtcaatgcttccatgtccaggttccctccccatatggtcccacca catcatacgctacacacgacgggcattccgcatccggccatagtcacaccaacagtcaaa caggaatcgtcccagagtgatgtcggctcactccatagttcaaagcatcaggactccaaa aaggaagaagaaaagaagaagccccacataaagaaacctcttaatgcattcatgttgtat atgaaggaaatgagagcaaaggtcgtagctgagtgcacgttgaaagaaagcgcggccatc aaccagatccttgggcggaggtggcatgcactgtccagagaagagcaagcgaaatactac gagctggcccggaaggagcgacagcttcatatgcaactgtaccccggctggtccgcgcgg gataactatggaaagaagaagaagaggaaaagggacaagcagccgggagagaccaatgat gcaaatactccaaagaagtgtcgggcactgttcgggcttgaccgacagactttatggtgc aaaccgtgcaggagaaaaaaaaagtgcgttcgctacatacaaggtgaaggcagctgcctc agcccaccctcttcagatggaagcttactagattcgcctcccccctccccgaacctgcta ggctcccctccccgagacgccaagtcacagactgagcagacccagcctctgtcgctgtcc ctgaagcccgaccccctggcccacctgtccatgatgcctccgccacccgccctcctgctc gctgaggccacccacaaggcctccgccctctgtcccaacggggccctggacctgccccca gccgctttgcagcctgccgccccctcctcatcaattgcacagccgtcgacttcttcctta cattcccacagctccctggccgggacccagccccagccgctgtcgctcgtcaccaagtct ttagaatag |
Protein Sequence |
>6934 : length: 602 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR DNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL SPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLL AEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKS LE |