Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6934

Name

TCF7L2

Synonymous

TCF-4|TCF4;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box)

Definition

HMG box transcription factor 4|T-cell factor 4|T-cell factor-4 variant A|T-cell factor-4 variant B|T-cell factor-4 variant C|T-cell factor-4 variant D|T-cell factor-4 variant E|T-cell factor-4 variant F|T-cell factor-4 variant G|T-cell factor-4 variant H|

Position

10q25.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

TCF-4E(h) --> CCND1(h) (DNA binding).
TCF-4E(h) + beta-catenin(h) <==> TCF-4E(h):beta-catenin(h) (binding).
TCF7L2(h) --> TCF-4E(h) (expression).
TCF-4B(h) + beta-catenin(h) <==> TCF-4B(h):beta-catenin(h) (binding).
TCF7L2(h) --> TCF-4B(h) (expression).
TCF-4(h) --> TCF7(h) (DNA binding).
TCF-4(h) --> MMP7(h) (DNA binding; transregulation).
TCF-4(h) --> c-myc(h) (DNA binding; transregulation).
TCF-4(h) --> FOSL1(h) (DNA binding).
TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding)
CtBP1(m) + TCF-4(h) <==> CtBP1(m):TCF-4(h) (binding)
CtBP1(h) + TCF-4(h) <==> CtBP1(h):TCF-4(h) (binding)
TCF-4(h) + CtBP2(m) <==> CtBP2(m):TCF-4(h) (binding)
Grg-1(m) + TCF-4(h) <==> Grg-1(m):TCF-4(h) (binding)
ESG3(m) + TCF-4(h) <==> ESG3(m):TCF-4(h) (binding)
Grg4(m) + TCF-4(h) <==> Grg4(m):TCF-4(h) (binding)
TCF-4(h) + TLE-2(h) <==> TCF-4(h):TLE-2(h) (binding)
TCF-4(h) + ATP --NLK(m)--> TCF-4(h){pT178}{pT189} + ADP (phosphorylation)
TCF-4(h) + NLK(m) <==> NLK(m):TCF-4(h) (binding)
beta-catenin(h) + TCF-4(h) + NLK(m) <==> beta-catenin(h):TCF-4(h):NLK(m) (binding)
beta-catenin(m) + TCF-4(h) <==> beta-catenin(m):TCF-4(h) (binding)
beta-catenin(ca) + TCF-4(h) <==> beta-catenin(ca):TCF-4(h) (binding)
plakoglobin(h) + TCF-4(h) <==> plakoglobin(h):TCF-4(h) (binding)
beta-catenin(h) + plakoglobin(h) + TCF-4(h) <==> beta-catenin(h):TCF-4(h):plakoglobin(h) (binding)
TCF-4(h) + ATP --CKII-alpha(r):CKII-alpha2(r):(CKII-beta(r))2--> TCF-4(h){pS60} + ADP (phosphorylation)
TCF-4(h) + Smad3(h) <==> TCF-4(h):Smad3(h) (binding)
TCF-4(h) + Smad4(h) <==> TCF-4(h):Smad4(h) (binding)
TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding)
TCF-4(h) + beta-catenin(h) + HIC-1(h) <==> TCF-4(h):beta-catenin(h):HIC-1(h) (binding)
TCF-4(h) + PARP(h) <==> TCF-4(h):PARP(h) (binding)
TCF-4(h) + Ku70(h) <==> TCF-4(h):Ku70(h) (binding)
TCF-4(h) + Ku80(h) <==> TCF-4(h):Ku80(h) (binding)
Ku70(m) + TCF-4(h) <==> Ku70(m):TCF-4(h) (binding)
TCF-4(h) + PARP(h) <==> TCF-4(h):PARP(h) (binding)
TCF-4(h) --> NOS2(h) (DNA binding).
TCF-4(h) --> CSPG2(h) (DNA binding; transactivation).
TCF-4(h) --> CCND1(h) (transactivation)
TCF-4(h) + NLK(m.s.) <==> TCF-4(h):NLK(m.s.) (binding)
TCF-4(h) + NLK(m.s.) + beta-catenin(m.s.) <==> TCF-4(h):NLK(m.s.):beta-catenin(m.s.) (binding)
TCF-4(h) + 2 ATP --NLK(m.s.)--> TCF-4(h){pT178}{pT189} + 2 ADP (phosphorylation)
beta-catenin(m.s.) + TCF-4(h) <==> beta-catenin(m.s.):TCF-4(h) (binding)
TCF-4(h) --> ABCB1(h) (transactivation)
Sox17(m) + TCF-4(h) <==> Sox17(m):TCF-4(h) (binding)
TCF-4(h) + Sox17(m) + beta-catenin(h) <==> TCF-4(h):Sox17(m):beta-catenin(h) (binding)
TCF-4(h) + Sox4(m) <==> TCF-4(h):Sox4(m) (binding)
TCF7L2(h) --> TCF-4(h) (expression).
TCF7L2(h) --> TCF-4(K)(h) (expression).
TCF7L2(h) --> TCF-4-isoform1(h) (expression).
TCF7L2(h) --> TCF-4-isoform2(h) (expression).
TCF7L2(h) --> TCF-4-isoform3(h) (expression).
TCF7L2(h) --> TCF-4-isoform4(h) (expression).
TCF7L2(h) --> TCF-4-isoform5(h) (expression).
TCF7L2(h) --> TCF-4-isoform6(h) (expression).
TCF7L2(h) --> TCF-4-isoform7(h) (expression).
HIC-1-isoform2(h) + TCF-4-isoform8(h) <==> HIC-1-isoform2(h):TCF-4-isoform8(h) (binding)
TCF7L2(h) --> TCF-4-isoform8(h) (expression).
TCF7L2(h) --> TCF-4-isoform9(h) (expression).
TCF7L2(h) --> TCF-4-isoform10(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 114698701 - 114700701GoldenGate_Methylation_Cancer_Panel_I

chr10

Promoter: 114698701 - 114700701GSE27584

chr10

Promoter: 114698701 - 114700701Agilent_014791_44K

chr10

Promoter: 114698701 - 114700701Agilent_014791


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