Entrez Gene

Basic Information
Gene ID	6934
Name	TCF7L2
Synonymous	transcription factor 7-like 2 (T-cell specific, HMG-box);TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box)
Definition	HMG box transcription factor 4\|T-cell factor 4\|T-cell factor-4 variant A\|T-cell factor-4 variant B\|T-cell factor-4 variant C\|T-cell factor-4 variant D\|T-cell factor-4 variant E\|T-cell factor-4 variant F\|T-cell factor-4 variant G\|T-cell factor-4 variant H\|
Position	10q25.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.32.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1465C>G; p.P489A; 10:113165646-113165646	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1035C>A; p.V345V; 10:113151827-113151827	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.866C>T; p.P289L; 10:113151057-113151057	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.932+1G>A; p.?; 10:113151124-113151124	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.546G>C; p.T182T; 10:113141246-113141246	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.332T>C; p.L111P; 10:112951558-112951558	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1458G>A; p.S486S; 10:113165639-113165639	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.187G>A; p.E63K; 10:112950943-112950943	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.80_82delAGG; p.E29delE; 10:112950836-112950838	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1185C>A; p.S395S; 10:113152425-113152425	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.916G>A; p.G306S; 10:113151107-113151107	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1472C>T; p.P491L; 10:113165653-113165653	skin	malignant_melanoma	Substitution - Missense
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - coding silent
c.1380A>G; p.K460K; 10:113165561-113165561	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - coding silent
c.49G>T; p.E17*; 10:112950805-112950805	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1393C>T; p.R465C; 10:113165574-113165574	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>T; p.G252*; 10:113146045-113146045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.R465C; 10:113165574-113165574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.590_591insA; p.P198fs*107; 10:113141290-113141291	large_intestine	NS	Insertion - Frameshift
c.1393C>A; p.R465S; 10:113165574-113165574	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.R153Q; 10:113040101-113040101	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>A; p.R363R; 10:113151879-113151879	thyroid	carcinoma	Substitution - coding silent
c.503T>C; p.V168A; 10:113141203-113141203	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1289C>T; p.P430L; 10:113158706-113158706	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1488C>T; p.S496S; 10:113165669-113165669	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1488C>T; p.S496S; 10:113165669-113165669	skin	malignant_melanoma	Substitution - coding silent
c.439C>T; p.Q147*; 10:113040082-113040082	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1606G>A; p.E536K; 10:113165787-113165787	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1063G>A; p.A355T; 10:113151855-113151855	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.381+1G>A; p.?; 10:112951608-112951608	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.1288C>T; p.P430S; 10:113158705-113158705	breast	carcinoma	Substitution - Missense
c.439C>T; p.Q147*; 10:113040082-113040082	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.818_834del17; p.H273fs*26; 10:113151009-113151025	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.698C>T; p.P233L; 10:113144004-113144004	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.835C>T; p.H279Y; 10:113151026-113151026	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1462C>T; p.P488S; 10:113165643-113165643	skin	malignant_melanoma	Substitution - Missense
c.1187C>T; p.A396V; 10:113152427-113152427	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1187C>T; p.A396V; 10:113152427-113152427	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1186G>A; p.A396T; 10:113152426-113152426	breast	carcinoma	Substitution - Missense
c.740C>T; p.P247L; 10:113146031-113146031	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>A; p.S46*; 10:112950893-112950893	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1131C>T; p.Y377Y; 10:113152371-113152371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.994A>G; p.N332D; 10:113151786-113151786	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.152A>G; p.E51G; 10:112950908-112950908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.904C>T; p.Q302*; 10:113151095-113151095	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.303C>A; p.P101P; 10:112951529-112951529	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1204_1206delAAG; p.K405delK; 10:113158024-113158026	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1377delA; p.K462fs*23; 10:113165558-113165558	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.932_932+1insGT; p.K312fs*1; 10:113151123-113151124	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1471C>T; p.P491S; 10:113165652-113165652	skin	malignant_melanoma	Substitution - Missense
c.1738C>G; p.L580V; 10:113165919-113165919	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1738C>G; p.L580V; 10:113165919-113165919	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.P431L; 10:113158709-113158709	skin	malignant_melanoma	Substitution - Missense
c.140C>T; p.S47F; 10:112950896-112950896	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.622C>T; p.P208S; 10:113143928-113143928	skin	malignant_melanoma	Substitution - Missense
c.1000delT; p.F334fs*5; 10:113151792-113151792	skin; trunk	malignant_melanoma	Deletion - Frameshift
c.398G>A; p.W133*; 10:113040041-113040041	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.398G>A; p.W133*; 10:113040041-113040041	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.622C>A; p.P208T; 10:113143928-113143928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>T; p.R153L; 10:113040101-113040101	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.218A>C; p.E73A; 10:112951235-112951235	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.461C>A; p.S154Y; 10:113040104-113040104	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1201-2A>G; p.?; 10:113158019-113158019	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.860C>T; p.P287L; 10:113151051-113151051	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.774C>A; p.P258P; 10:113146065-113146065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002C>A; p.F334L; 10:113151794-113151794	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1362C>T; p.C454C; 10:113159981-113159981	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1002C>A; p.F334L; 10:113151794-113151794	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1002C>A; p.F334L; 10:113151794-113151794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1025G>T; p.R342I; 10:113151817-113151817	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1200+2T>C; p.?; 10:113152442-113152442	large_intestine	carcinoma; adenocarcinoma	Unknown
c.1766C>T; p.S589L; 10:113165947-113165947	liver	carcinoma	Substitution - Missense
c.1468T>C; p.S490P; 10:113165649-113165649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1741G>T; p.A581S; 10:113165922-113165922	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1394G>A; p.R465H; 10:113165575-113165575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.469C>T; p.P157S; 10:113040112-113040112	skin	malignant_melanoma	Substitution - Missense
c.657T>G; p.Y219*; 10:113143963-113143963	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1240G>T; p.E414*; 10:113158060-113158060	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Nonsense
c.1081C>T; p.L361F; 10:113151873-113151873	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.746C>T; p.T249M; 10:113146037-113146037	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1473G>A; p.P491P; 10:113165654-113165654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.416delA; p.Q139fs*63; 10:113040059-113040059	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1457C>T; p.S486L; 10:113165638-113165638	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.76G>C; p.E26Q; 10:112950832-112950832	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.616G>A; p.G206R; 10:113141316-113141316	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.616G>A; p.G206R; 10:113141316-113141316	large_intestine; caecum	adenoma	Substitution - Missense
c.1068C>A; p.A356A; 10:113151860-113151860	ovary	other; neoplasm	Substitution - coding silent
c.932C>T; p.S311L; 10:113151123-113151123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1163_1164insT; p.M388fs*12; 10:113152403-113152404	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1552G>A; p.D518N; 10:113165733-113165733	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1163_1164insT; p.M388fs*12; 10:113152403-113152404	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1552G>A; p.D518N; 10:113165733-113165733	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1767G>A; p.S589S; 10:113165948-113165948	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1329G>A; p.A443A; 10:113159948-113159948	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1680C>T; p.A560A; 10:113165861-113165861	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1157T>G; p.L386R; 10:113152397-113152397	central_nervous_system; brain	glioma	Substitution - Missense
c.1330C>T; p.R444C; 10:113159949-113159949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.747G>A; p.T249T; 10:113146038-113146038	skin	malignant_melanoma	Substitution - coding silent
c.1379_1400del22; p.K460fs*18; 10:113165560-113165581	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.888C>T; p.V296V; 10:113151079-113151079	large_intestine; rectum	adenoma	Substitution - coding silent
c.1379_1400del22; p.K460fs*18; 10:113165560-113165581	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.690delC; p.H232fs*3; 10:113143996-113143996	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1093-2A>T; p.?; 10:113152331-113152331	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.566C>T; p.T189M; 10:113141266-113141266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1775C>A; p.T592N; 10:113165956-113165956	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.699G>A; p.P233P; 10:113144005-113144005	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1009T>C; p.Y337H; 10:113151801-113151801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.P289S; 10:113151056-113151056	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1159C>A; p.H387N; 10:113152399-113152399	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1159C>A; p.H387N; 10:113152399-113152399	liver	carcinoma	Substitution - Missense
c.70G>T; p.E24*; 10:112950826-112950826	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1584G>A; p.P528P; 10:113165765-113165765	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1494C>T; p.P498P; 10:113165675-113165675	skin	malignant_melanoma	Substitution - coding silent
c.1584G>A; p.P528P; 10:113165765-113165765	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.221G>C; p.S74T; 10:112951238-112951238	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.542T>C; p.I181T; 10:113141242-113141242	central_nervous_system; brainstem	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1465C>T; p.P489S; 10:113165646-113165646	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1176C>T; p.P392P; 10:113152416-113152416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1388G>A; p.C463Y; 10:113165569-113165569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1376_1377insA; p.C463fs*8; 10:113165557-113165558	large_intestine; rectum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1293G>A; p.P431P; 10:113158710-113158710	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1192G>T; p.D398Y; 10:113152432-113152432	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.525delC; p.L177fs*25; 10:113141225-113141225	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.772C>A; p.P258T; 10:113146063-113146063	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.772C>A; p.P258T; 10:113146063-113146063	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.525delC; p.L177fs*25; 10:113141225-113141225	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1121C>T; p.A374V; 10:113152361-113152361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1122G>A; p.A374A; 10:113152362-113152362	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1121C>T; p.A374V; 10:113152361-113152361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>A; p.V201I; 10:113141301-113141301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.862C>T; p.H288Y; 10:113151053-113151053	breast	carcinoma	Substitution - Missense
c.1158T>C; p.L386L; 10:113152398-113152398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1189C>T; p.R397W; 10:113152429-113152429	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1189C>T; p.R397W; 10:113152429-113152429	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.604G>T; p.D202Y; 10:113141304-113141304	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1013T>G; p.M338R; 10:113151805-113151805	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.26G>A; p.G9E; 10:112950782-112950782	skin	malignant_melanoma	Substitution - Missense
c.1338C>T; p.G446G; 10:113159957-113159957	liver	carcinoma	Substitution - coding silent
c.840G>A; p.T280T; 10:113151031-113151031	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.598G>A; p.D200N; 10:113141298-113141298	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.771C>A; p.Y257*; 10:113146062-113146062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1201-1G>C; p.?; 10:113158020-113158020	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.771C>A; p.Y257*; 10:113146062-113146062	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1755C>T; p.P585P; 10:113165936-113165936	skin	malignant_melanoma	Substitution - coding silent
c.1536G>A; p.S512S; 10:113165717-113165717	large_intestine; colon	NS	Substitution - coding silent
c.1556C>T; p.P519L; 10:113165737-113165737	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1150C>T; p.R384*; 10:113152390-113152390	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.238C>A; p.R80R; 10:112951255-112951255	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.584C>T; p.P195L; 10:113141284-113141284	skin	malignant_melanoma	Substitution - Missense
c.1626C>T; p.S542S; 10:113165807-113165807	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1199A>G; p.Y400C; 10:113152439-113152439	liver	carcinoma	Substitution - Missense
c.1694C>T; p.S565L; 10:113165875-113165875	fallopian_tube	carcinoma; serous_carcinoma	Substitution - Missense
c.692C>T; p.P231L; 10:113143998-113143998	skin	malignant_melanoma	Substitution - Missense
c.143T>C; p.L48P; 10:112950899-112950899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1389C>T; p.C463C; 10:113165570-113165570	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.551_552GC>TT; p.S184>?; 10:113141251-113141252	large_intestine; rectum	carcinoma; adenocarcinoma	Complex
c.1077G>T; p.Q359H; 10:113151869-113151869	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.545C>T; p.T182M; 10:113141245-113141245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1132G>T; p.E378*; 10:113152372-113152372	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Substitution - Nonsense
c.1132G>T; p.E378*; 10:113152372-113152372	pancreas	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.1191G>T; p.R397R; 10:113152431-113152431	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.505C>T; p.Q169*; 10:113141205-113141205	liver	carcinoma	Substitution - Nonsense
c.1692A>G; p.S564S; 10:113165873-113165873	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.505C>T; p.Q169*; 10:113141205-113141205	liver	carcinoma	Substitution - Nonsense
c.1401A>G; p.I467M; 10:113165582-113165582	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1682C>T; p.A561V; 10:113165863-113165863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259G>A; p.A87T; 10:112951485-112951485	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.259G>A; p.A87T; 10:112951485-112951485	urinary_tract; bladder	carcinoma	Substitution - Missense
c.534G>A; p.T178T; 10:113141234-113141234	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140C>T; p.A380A; 10:113152380-113152380	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.1140C>T; p.A380A; 10:113152380-113152380	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1430C>T; p.P477L; 10:113165611-113165611	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1062C>T; p.S354S; 10:113151854-113151854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.556G>T; p.E186*; 10:113141256-113141256	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1561G>A; p.A521T; 10:113165742-113165742	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1378A>C; p.K460Q; 10:113165559-113165559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.915C>T; p.V305V; 10:113151106-113151106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.915C>T; p.V305V; 10:113151106-113151106	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.774C>T; p.P258P; 10:113146065-113146065	skin	malignant_melanoma	Substitution - coding silent
c.567G>A; p.T189T; 10:113141267-113141267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1505A>G; p.K502R; 10:113165686-113165686	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1703A>G; p.Q568R; 10:113165884-113165884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1375_1376insG; p.C463fs*8; 10:113165556-113165557	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1182G>T; p.W394C; 10:113152422-113152422	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]