| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7520 |
Name | XRCC5 |
Synonym | KARP-1|KARP1|KU80|KUB2|Ku86|NFIV;X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);XRCC5;X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
Definition | 86 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku autoantigen, 80kDa|Ku86 autoantigen related protein 1|TLAA|X-ray |
Position | 2q35 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 17944 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Non-homologous end-joining;KEGG PATHWAY;hsa03450 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | Nonhomologous End-joining (NHEJ);PID Reactome;500055 |
Pathway | HIV Infection;Reactome;REACT:6185 |
Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Pathway | telomeres telomerase cellular aging and immortality;PID BioCarta;100021 |
Disease | esophageal cancer gastric cardiac adenocarcinoma;GAD |
Disease | CANCER;GAD |
Disease | cancer;GAD |
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External Links |
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Links to Entrez Gene | 7520 |
Links to all GeneRIF Items | 7520 |
Links to iHOP | 7520 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>7520 : length: 2199 atggtgcggtcggggaataaggcagctgttgtgctgtgtatggacgtgggctttaccatg agtaactccattcctggtatagaatccccatttgaacaagcaaagaaggtgataaccatg tttgtacagcgacaggtgtttgctgagaacaaggatgagattgctttagtcctgtttggt acagatggcactgacaatcccctttctggtggggatcagtatcagaacatcacagtgcac agacatctgatgctaccagattttgatttgctggaggacattgaaagcaaaatccaacca ggttctcaacaggctgacttcctggatgcactaatcgtgagcatggatgtgattcaacat gaaacaataggaaagaagtttgagaagaggcatattgaaatattcactgacctcagcagc cgattcagcaaaagtcagctggatattataattcatagcttgaagaaatgtgacatctcc ctgcaattcttcttgcctttctcacttggcaaggaagatggaagtggggacagaggagat ggcccctttcgcttaggtggccatgggccttcctttccactaaaaggaattaccgaacag caaaaagaaggtcttgagatagtgaaaatggtgatgatatctttagaaggtgaagatggg ttggatgaaatttattcattcagtgagagtctgagaaaactgtgcgtcttcaagaaaatt gagaggcattccattcactggccctgccgactgaccattggctccaatttgtctataagg attgcagcctataaatcgattctacaggagagagttaaaaagacttggacagttgtggat gcaaaaaccctaaaaaaagaagatatacaaaaagaaacagtttattgcttaaatgatgat gatgaaactgaagttttaaaagaggatattattcaagggttccgctatggaagtgatata gttcctttctctaaagtggatgaggaacaaatgaaatataaatcggaggggaagtgcttc tctgttttgggattttgtaaatcttctcaggttcagagaagattcttcatgggaaatcaa gttctaaaggtctttgcagcaagagatgatgaggcagctgcagttgcactttcctccctg attcatgctttggatgacttagacatggtggccatagttcgatatgcttatgacaaaaga gctaatcctcaagtcggcgtggcttttcctcatatcaagcataactatgagtgtttagtg tatgtgcagctgcctttcatggaagacttgcggcaatacatgttttcatccttgaaaaac agtaagaaatatgctcccaccgaggcacagttgaatgctgttgatgctttgattgactcc atgagcttggcaaagaaagatgagaagacagacacccttgaagacttgtttccaaccacc aaaatcccaaatcctcgatttcagagattatttcagtgtctgctgcacagagctttacat ccccgggagcctctacccccaattcagcagcatatttggaatatgctgaatcctcccgct gaggtgacaacaaaaagtcagattcctctctctaaaataaagaccctttttcctctgatt gaagccaagaaaaaggatcaagtgactgctcaggaaattttccaagacaaccatgaagat ggacctacagctaaaaaattaaagactgagcaagggggagcccacttcagcgtctccagt ctggctgaaggcagtgtcacctctgttggaagtgtgaatcctgctgaaaacttccgtgtt ctagtgaaacagaagaaggccagctttgaggaagcgagtaaccagctcataaatcacatc gaacagtttttggatactaatgaaacaccgtattttatgaagagcatagactgcatccga gccttccgggaagaagccattaagttttcagaagagcagcgctttaacaacttcctgaaa gcccttcaagagaaagtggaaattaaacaattaaatcatttctgggaaattgttgtccag gatggaattactctgatcaccaaagaggaagcctctggaagttctgtcacagctgaggaa gccaaaaagtttctggcccccaaagacaaaccaagtggagacacagcagctgtatttgaa gaaggtggtgatgtggacgatttattggacatgatatag |
Protein Sequence |
>7520 : length: 732 MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE EGGDVDDLLDMI |