| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8312 |
Name | AXIN1 |
Synonym | AXIN|PPP1R49;axin 1;AXIN1;axin 1 |
Definition | axin-1|axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of|protein phosphatase 1, regulatory subunit 49 |
Position | 16p13.3 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 138 |
TUSON P-value | 0.000115029 |
|
Pathways and Diseases |
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Pathway | Presenilin action in Notch and Wnt signaling;PID Curated;200052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Degradation of beta-catenin by the destruction complex;PID Reactome;500310 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | Canonical Wnt signaling pathway;PID Curated;200064 |
Pathway | multi-step regulation of transcription by pitx2;PID BioCarta;100074 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Signaling by Wnt;Reactome;REACT:11045 |
Pathway | N-cadherin signaling events;PID Curated;200180 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | wnt signaling pathway;PID BioCarta;100002 |
Pathway | segmentation clock;PID BioCarta;100146 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | C-MYC pathway;PID Curated;200093 |
Disease | Caudal duplication anomaly;OMIM |
Disease | Hepatocellular carcinoma, somatic;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Cancers of the digestive system;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 8312 |
Links to all GeneRIF Items | 8312 |
Links to iHOP | 8312 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>8312 : length: 2589 atgaatatccaagagcagggtttccccttggacctcggagcaagtttcaccgaagatgct ccccgacccccagtgcctggtgaggagggagaactggtgtccacagacccgaggcccgcc agctacagtttctgctccgggaaaggtgttggcattaaaggtgagacttcgacggccact ccgaggcgctcggatctggacctggggtatgagcctgagggcagtgcctcccccacccca ccatacttgaagtgggctgagtcactgcattccctgctggatgaccaagatgggataagc ctgttcaggactttcctgaagcaggagggctgtgccgacttgctggacttctggtttgcc tgcactggcttcaggaagctggagccctgtgactcgaacgaggagaagaggctgaagctg gcgagagccatctaccgaaagtacattcttgataacaatggcatcgtgtcccggcagacc aagccagccaccaagagcttcataaagggctgcatcatgaagcagctgatcgatcctgcc atgtttgaccaggcccagaccgaaatccaggccactatggaggaaaacacctatccctcc ttccttaagtctgatatttatttggaatatacgaggacaggctcggagagccccaaagtc tgtagtgaccagagctctgggtcagggacagggaagggcatatctggatacctgccgacc ttaaatgaagatgaggaatggaagtgtgaccaggacatggatgaggacgatggcagagac gctgctccccccggaagactccctcagaagctgctcctggagacagctgccccgagggtc tcctccagtagacggtacagcgaaggcagagagttcaggtatggatcctggcgggagcca gtcaacccctattatgtcaatgccggctatgccctggccccagccaccagtgccaacgac agcgagcagcagagcctgtccagcgatgcagacaccctgtccctcacggacagcagcgtg gatgggatccccccatacaggatccgtaagcagcaccgcagggagatgcaggagagcgtg caggtcaatgggcgggtgcccctacctcacattccccgcacgtaccgggtgccgaaggag gtccgcgtggagcctcagaagttcgcggaggagctcatccaccgcctggaggctgtgcag cgcacgcgggaggccgaggagaagctggaggagcggctgaagcgcgtgcgcatggaggag gaaggtgaggacggcgatccatcgtcagggcccccagggccgtgtcacaagctgcctccc gcccccgcttggcaccacttcccgccccgctgtgtggacatgggctgtgccgggctccgg gatgcacacgaggagaaccctgagagcatcctggacgagcacgtacagcgtgtgctgagg acacctggccgccagtcgcctgggcctggccatcgctccccggacagtgggcacgtggcc aagatgccagtggcactggggggtgccgcctcggggcacgggaagcacgtacccaagtca ggggcgaagctggacgcggccggcctgcaccaccaccgacacgtccaccaccacgtccac cacagcacagcccggcccaaggagcaggtggaggccgaggccacccgcagggcccagagc agcttcgcctggggcctggaaccacacagccatggggcaaggtcccgaggctactcagag agtgttggcgctgcccccaacgccagtgatggcctcgcccacagtgggaaggtgggcgtg gcgtgcaaaagaaatgccaagaaggctgagtcggggaagagcgccagcaccgaggtgcca ggtgcctcggaggatgcggagaagaaccagaaaatcatgcagtggatcattgagggggaa aaggagatcagcaggcaccgcaggaccggccacgggtcttcggggacgaggaagccacag ccccatgagaactccagacccttgtcccttgagcacccctgggccggccctcagctccgg acctccgtgcagccctcccacctcttcatccaagaccccaccatgccaccccacccagct cccaaccccctaacccagctggaggaggcgcgccgacgtctggaggaggaagaaaagaga gccagccgagcaccctccaagcagaggtatgtgcaggaggttatgcggcggggacgcgcc tgcgtcaggccagcgtgcgcgccggtgctgcacgtggtaccagccgtgtcggacatggag ctctccgagacagagacaagatcgcagaggaaggtgggcggcgggagtgcccagccgtgt gacagcatcgttgtggcgtactacttctgcggggaacccatcccctaccgcaccctggtg aggggccgcgctgtcaccctgggccagttcaaggagctgctgaccaaaaagggcagctac agatactacttcaagaaagtgagcgacgagtttgactgtggggtggtgtttgaggaggtt cgagaggacgaggccgtcctgcccgtctttgaggagaagatcatcggcaaagtggagaag gtggactga |
Protein Sequence |
>8312 : length: 862 MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPT LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP VNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESV QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEE EGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVH HSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQ PHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKR ASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPC DSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEV REDEAVLPVFEEKIIGKVEKVD |