Entrez Gene

Basic Information
Gene ID	8312
Name	AXIN1
Synonymous	axin 1;AXIN1;axin 1
Definition	axin-1\|axis inhibition protein 1\|axis inhibitor 1\|fused, mouse, homolog of\|protein phosphatase 1, regulatory subunit 49
Position	16p13.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.42.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.891G>C; p.W297C; 16:314671-314671	prostate	carcinoma	Substitution - Missense
c.273C>T; p.S91S; 16:346753-346753	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1566G>A; p.A522A; 16:297940-297940	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1885A>G; p.N629D; 16:297126-297126	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.255G>A; p.W85*; 16:346771-346771	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2484C>T; p.S828S; 16:288227-288227	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2484C>T; p.S828S; 16:288227-288227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2484C>T; p.S828S; 16:288227-288227	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.255G>A; p.W85*; 16:346771-346771	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1021delG; p.D341fs*73; 16:310068-310068	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.768C>T; p.D256D; 16:346258-346258	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.482A>C; p.K161T; 16:346544-346544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.373A>T; p.R125W; 16:346653-346653	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.941C>T; p.P314L; 16:314621-314621	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2539C>T; p.L847L; 16:288172-288172	skin	malignant_melanoma	Substitution - coding silent
c.1605C>A; p.V535V; 16:297901-297901	liver	other; hepatoblastoma	Substitution - coding silent
c.227C>T; p.A76V; 16:346799-346799	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.227C>T; p.A76V; 16:346799-346799	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2152G>A; p.E718K; 16:293522-293522	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1740G>C; p.E580D; 16:297766-297766	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1694G>A; p.G565D; 16:297812-297812	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.227C>T; p.A76V; 16:346799-346799	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2021G>A; p.W674*; 16:293653-293653	liver	carcinoma	Substitution - Nonsense
c.2021G>A; p.W674*; 16:293653-293653	liver	carcinoma	Substitution - Nonsense
c.727G>T; p.E243*; 16:346299-346299	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Nonsense
c.428C>A; p.A143D; 16:346598-346598	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.2404G>A; p.G802S; 16:289498-289498	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2404G>A; p.G802S; 16:289498-289498	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.960delC; p.D320fs*94; 16:314602-314602	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.2303C>A; p.S768*; 16:289599-289599	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.2057C>T; p.S686F; 16:293617-293617	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.223A>G; p.S75G; 16:346803-346803	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2057C>T; p.S686F; 16:293617-293617	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.223A>G; p.S75G; 16:346803-346803	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1984C>T; p.H662Y; 16:293690-293690	skin	malignant_melanoma	Substitution - Missense
c.2319C>T; p.G773G; 16:289583-289583	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1931G>A; p.S644N; 16:297080-297080	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2134C>T; p.R712*; 16:293540-293540	liver	carcinoma	Substitution - Nonsense
c.2134C>T; p.R712*; 16:293540-293540	liver	carcinoma	Substitution - Nonsense
c.1724C>T; p.S575F; 16:297782-297782	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1598G>A; p.R533Q; 16:297908-297908	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2521C>T; p.R841*; 16:288190-288190	skin	malignant_melanoma	Substitution - Nonsense
c.398A>G; p.N133S; 16:346628-346628	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.19G>A; p.G7S; 16:347007-347007	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1599_1600ins12; p.R533_H534insQVHH; 16:297906-297907	liver	carcinoma; hepatocellular_carcinoma	Insertion - In frame
c.891G>A; p.W297*; 16:314671-314671	liver	carcinoma	Substitution - Nonsense
c.891G>A; p.W297*; 16:314671-314671	liver	carcinoma	Substitution - Nonsense
c.971A>T; p.Q324L; 16:314591-314591	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1648G>A; p.V550M; 16:297858-297858	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.97G>A; p.V33M; 16:346929-346929	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.989C>T; p.A330V; 16:314573-314573	thyroid	carcinoma	Substitution - Missense
c.1955G>C; p.G652A; 16:297056-297056	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1905G>A; p.W635*; 16:297106-297106	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1390G>A; p.E464K; 16:298116-298116	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.118G>A; p.A40T; 16:346908-346908	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1298G>A; p.G433E; 16:298208-298208	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1235G>A; p.R412Q; 16:304323-304323	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1133C>T; p.P378L; 16:304425-304425	prostate	carcinoma	Substitution - Missense
c.58G>T; p.A20S; 16:346968-346968	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1005_1006insGTCCCTC; p.T336fs*17; 16:314556-314557	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.893G>T; p.R298L; 16:314669-314669	prostate	carcinoma	Substitution - Missense
c.1603G>A; p.V535I; 16:297903-297903	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.182C>T; p.P61L; 16:346844-346844	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2529C>T; p.D843D; 16:288182-288182	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1651G>T; p.E551*; 16:297855-297855	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.964G>A; p.E322K; 16:314598-314598	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1081_1082insGTGT; p.Q361fs*64; 16:310007-310008	liver	carcinoma	Insertion - Frameshift
c.540delC; p.M181fs*61; 16:346486-346486	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1025G>A; p.G342E; 16:310064-310064	skin	malignant_melanoma	Substitution - Missense
c.1665C>A; p.T555T; 16:297841-297841	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.226G>A; p.A76T; 16:346800-346800	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.226G>A; p.A76T; 16:346800-346800	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.226G>A; p.A76T; 16:346800-346800	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2223C>T; p.C741C; 16:291261-291261	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.226G>A; p.A76T; 16:346800-346800	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.638C>T; p.T213I; 16:346388-346388	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.921T>A; p.N307K; 16:314641-314641	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1798G>A; p.V600M; 16:297213-297213	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.638C>T; p.T213I; 16:346388-346388	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1615G>A; p.V539I; 16:297891-297891	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1615G>A; p.V539I; 16:297891-297891	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1732T>C; p.Y578H; 16:297774-297774	skin	malignant_melanoma	Substitution - Missense
c.1597C>T; p.R533*; 16:297909-297909	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1597C>T; p.R533*; 16:297909-297909	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.(1450-1464)del13; p.(R484)fs*?; 16:298056-298056	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.(1036-1050)del13; p.(Y346)fs*?; 16:310053-310053	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.2501G>A; p.G834E; 16:288210-288210	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1597C>T; p.R533*; 16:297909-297909	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1877C>T; p.A626V; 16:297134-297134	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.861C>T; p.S287S; 16:346165-346165	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186C>A; p.L396M; 16:304372-304372	large_intestine; colon	carcinoma	Substitution - Missense
c.964_964delG; p.E322fs*92; 16:314598-314598	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.232C>T; p.P78S; 16:346794-346794	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1747G>A; p.G583S; 16:297759-297759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.52G>T; p.E18*; 16:346974-346974	liver	carcinoma	Substitution - Nonsense
c.2317G>T; p.G773C; 16:289585-289585	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1576G>T; p.A526S; 16:297930-297930	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.735G>A; p.E245E; 16:346291-346291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.320_321AG>TA; p.K107>?; 16:346705-346706	large_intestine; rectum	carcinoma; adenocarcinoma	Complex
c.2410G>A; p.A804T; 16:289492-289492	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.915T>A; p.Y305*; 16:314647-314647	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.400G>A; p.E134K; 16:346626-346626	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1207C>T; p.R403W; 16:304351-304351	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.305delT; p.F102fs*5; 16:346721-346721	liver	carcinoma	Deletion - Frameshift
c.1207C>T; p.R403W; 16:304351-304351	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.998_999insGTCCCTC; p.T336fs*17; 16:314563-314564	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1371C>A; p.A457A; 16:298135-298135	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.519G>A; p.M173I; 16:346507-346507	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1912G>A; p.E638K; 16:297099-297099	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1670G>A; p.R557K; 16:297836-297836	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1125C>T; p.Y375Y; 16:304433-304433	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.639_639delA; p.G214fs*28; 16:346387-346387	oesophagus	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.2426A>G; p.Q809R; 16:289476-289476	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1336C>A; p.H446N; 16:298170-298170	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1784+26G>C; p.?; 16:297696-297696	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.2179A>T; p.K727*; 16:293495-293495	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2251C>T; p.H751Y; 16:291233-291233	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.980C>T; p.S327F; 16:314582-314582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2082C>T; p.T694T; 16:293592-293592	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2082C>T; p.T694T; 16:293592-293592	skin	malignant_melanoma	Substitution - coding silent
c.759G>A; p.M253I; 16:346267-346267	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2479_2479delG; p.V827fs*1; 16:288232-288232	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.2174C>T; p.P725L; 16:293500-293500	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.E246K; 16:346290-346290	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.70C>T; p.P24S; 16:346956-346956	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1725C>T; p.S575S; 16:297781-297781	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.652C>T; p.P218S; 16:346374-346374	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.652C>T; p.P218S; 16:346374-346374	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.652C>T; p.P218S; 16:346374-346374	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma; classic	Substitution - Missense
c.1843G>A; p.A615T; 16:297168-297168	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.683C>T; p.S228L; 16:346343-346343	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.751C>T; p.Q251*; 16:346275-346275	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1381G>A; p.D461N; 16:298125-298125	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2047G>A; p.V683M; 16:293627-293627	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1967C>T; p.T656M; 16:293707-293707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1967C>T; p.T656M; 16:293707-293707	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.793_794insC; p.G265fs*20; 16:346232-346233	stomach	carcinoma; intestinal_adenocarcinoma	Insertion - Frameshift
c.1703_1703delC; p.P568fs*137; 16:297803-297803	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1116+1G>A; p.?; 16:309972-309972	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1116+1G>A; p.?; 16:309972-309972	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1159A>T; p.K387*; 16:304399-304399	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1523delG; p.G508fs*197; 16:297983-297983	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2265C>T; p.A755A; 16:291219-291219	pancreas	carcinoma	Substitution - coding silent
c.1523delG; p.G508fs*197; 16:297983-297983	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1523delG; p.G508fs*197; 16:297983-297983	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1523delG; p.G508fs*197; 16:297983-297983	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2517G>T; p.E839D; 16:288194-288194	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.957C>T; p.N319N; 16:314605-314605	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1464G>T; p.G488G; 16:298042-298042	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1765A>G; p.S589G; 16:297741-297741	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.957C>T; p.N319N; 16:314605-314605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.191C>A; p.S64*; 16:346835-346835	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Nonsense
c.865_865delG; p.G289fs*125; 16:346161-346161	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.417G>T; p.K139N; 16:346609-346609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1576G>A; p.A526T; 16:297930-297930	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1153C>G; p.P385A; 16:304405-304405	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1868C>A; p.S623*; 16:297143-297143	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1868C>A; p.S623*; 16:297143-297143	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.259G>A; p.E87K; 16:346767-346767	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2503delG; p.V835fs*>28; 16:288208-288208	liver	carcinoma	Deletion - Frameshift
c.224G>A; p.S75N; 16:346802-346802	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.236C>T; p.T79I; 16:346790-346790	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.236C>T; p.T79I; 16:346790-346790	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.236C>T; p.T79I; 16:346790-346790	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.236C>T; p.T79I; 16:346790-346790	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1827T>C; p.A609A; 16:297184-297184	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1827T>C; p.A609A; 16:297184-297184	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1152_1177del26; p.E384fs*31; 16:304381-304406	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.462C>T; p.G154G; 16:346564-346564	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1130T>C; p.V377A; 16:304428-304428	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1254G>A; p.M418I; 16:304304-304304	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.308G>T; p.R103M; 16:346718-346718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1836_1836delG; p.K613fs*92; 16:297175-297175	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1472A>G; p.H491R; 16:298034-298034	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1500C>T; p.A500A; 16:298006-298006	skin	carcinoma; Merkel_cell_carcinoma	Substitution - coding silent
c.1216G>T; p.E406*; 16:304342-304342	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1216G>T; p.E406*; 16:304342-304342	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1475G>A; p.R492H; 16:298031-298031	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.762T>C; p.D254D; 16:346264-346264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.762T>C; p.D254D; 16:346264-346264	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.67C>T; p.P23S; 16:346959-346959	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.67C>T; p.P23S; 16:346959-346959	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.(1156_1167)del5; p.(386)fs*?; 16:304402-304402	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1045C>T; p.R349C; 16:310044-310044	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.792delC; p.G265fs*149; 16:346234-346234	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2534C>T; p.A845V; 16:288177-288177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.141G>A; p.G47G; 16:346885-346885	skin	malignant_melanoma	Substitution - coding silent
c.1958C>G; p.S653C; 16:293716-293716	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.793G>T; p.G265*; 16:346233-346233	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.991_991delG; p.D331fs*83; 16:314571-314571	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.991_991delG; p.D331fs*83; 16:314571-314571	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.2244G>A; p.P748P; 16:291240-291240	thyroid	carcinoma	Substitution - coding silent
c.139G>A; p.G47R; 16:346887-346887	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.991_991delG; p.D331fs*83; 16:314571-314571	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.618T>G; p.I206M; 16:346408-346408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1231_1232insT; p.E411fs*13; 16:304326-304327	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1745T>C; p.V582A; 16:297761-297761	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1231_1232insT; p.E411fs*13; 16:304326-304327	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.125A>G; p.Y42C; 16:346901-346901	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1943G>A; p.R648K; 16:297068-297068	skin	malignant_melanoma	Substitution - Missense
c.125A>G; p.Y42C; 16:346901-346901	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1945A>C; p.T649P; 16:297066-297066	pancreas	carcinoma	Substitution - Missense
c.2371G>T; p.G791W; 16:289531-289531	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2336C>T; p.P779L; 16:289566-289566	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1945A>C; p.T649P; 16:297066-297066	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2336C>T; p.P779L; 16:289566-289566	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1144C>T; p.R382C; 16:304414-304414	skin	malignant_melanoma	Substitution - Missense
c.1183C>T; p.R395C; 16:304375-304375	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1183C>T; p.R395C; 16:304375-304375	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1183C>T; p.R395C; 16:304375-304375	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1573G>A; p.D525N; 16:297933-297933	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1592A>G; p.H531R; 16:297914-297914	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.869G>A; p.R290K; 16:346157-346157	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1741_1742delAG; p.S581fs*9; 16:297764-297765	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1741_1742delAG; p.S581fs*9; 16:297764-297765	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.61C>T; p.P21S; 16:346965-346965	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2118G>A; p.Q706Q; 16:293556-293556	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1273G>A; p.G425S; 16:298233-298233	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2118G>A; p.Q706Q; 16:293556-293556	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1714G>A; p.G572R; 16:297792-297792	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2187-12G>A; p.?; 16:291309-291309	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Unknown
c.1714G>A; p.G572R; 16:297792-297792	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1714G>A; p.G572R; 16:297792-297792	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1714G>A; p.G572R; 16:297792-297792	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.437G>A; p.R146Q; 16:346589-346589	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.437G>A; p.R146Q; 16:346589-346589	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918delG; p.E640fs*65; 16:297093-297093	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.437G>A; p.R146Q; 16:346589-346589	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1918delG; p.E640fs*65; 16:297093-297093	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2430C>G; p.F810L; 16:289472-289472	urinary_tract; bladder	carcinoma	Substitution - Missense
c.364A>G; p.T122A; 16:346662-346662	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1540G>A; p.G514R; 16:297966-297966	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2090C>T; p.P697L; 16:293584-293584	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.362G>T; p.C121F; 16:346664-346664	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.827C>T; p.A276V; 16:346199-346199	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1164C>T; p.F388F; 16:304394-304394	skin	malignant_melanoma	Substitution - coding silent
c.1828G>T; p.E610*; 16:297183-297183	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.324G>T; p.Q108H; 16:346702-346702	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1460C>T; p.P487L; 16:298046-298046	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.128G>A; p.S43N; 16:346898-346898	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2294A>G; p.E765G; 16:291190-291190	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1020-9C>T; p.?; 16:310078-310078	skin; trunk	malignant_melanoma; nodular	Unknown
c.128G>A; p.S43N; 16:346898-346898	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.959A>G; p.D320G; 16:314603-314603	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - Missense
c.64delC; p.R22fs*62; 16:346962-346962	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1961C>T; p.S654L; 16:293713-293713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2187-2A>G; p.?; 16:291299-291299	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1542G>A; p.G514G; 16:297964-297964	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1116_1116delC; p.R373fs*41; 16:309973-309973	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma; classic	Deletion - Frameshift
c.1946C>T; p.T649I; 16:297065-297065	skin	malignant_melanoma	Substitution - Missense
c.192G>A; p.S64S; 16:346834-346834	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.192G>A; p.S64S; 16:346834-346834	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2382C>T; p.I794I; 16:289520-289520	skin	malignant_melanoma	Substitution - coding silent
c.1114C>T; p.P372S; 16:309975-309975	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1611C>T; p.H537H; 16:297895-297895	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1797C>T; p.G599G; 16:297214-297214	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1691G>A; p.W564*; 16:297815-297815	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Nonsense
c.2482A>G; p.S828G; 16:288229-288229	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1691G>A; p.W564*; 16:297815-297815	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Nonsense
c.2295-1G>A; p.?; 16:289608-289608	liver	carcinoma	Unknown
c.2295-1G>A; p.?; 16:289608-289608	liver	carcinoma	Unknown
c.1475G>T; p.R492L; 16:298031-298031	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.672G>C; p.Q224H; 16:346354-346354	breast	carcinoma	Substitution - Missense
c.746G>T; p.C249F; 16:346280-346280	breast	carcinoma	Substitution - Missense
c.556C>T; p.Q186*; 16:346470-346470	liver	carcinoma	Substitution - Nonsense
c.2487C>T; p.D829D; 16:288224-288224	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1581C>T; p.A527A; 16:297925-297925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1979_1983delAGCCC; p.Q660fs*2; 16:293691-293695	liver	carcinoma	Deletion - Frameshift
c.1922delA; p.K641fs*64; 16:297089-297089	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1922delA; p.K641fs*64; 16:297089-297089	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1463G>T; p.G488V; 16:298043-298043	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.12A>C; p.Q4H; 16:347014-347014	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1231_1232insA; p.R412fs*12; 16:304326-304327	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.1231_1232insA; p.R412fs*12; 16:304326-304327	liver	carcinoma; hepatocellular_carcinoma	Insertion - Frameshift
c.568C>T; p.Q190*; 16:346458-346458	liver	carcinoma	Substitution - Nonsense
c.568C>T; p.Q190*; 16:346458-346458	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.568C>T; p.Q190*; 16:346458-346458	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1134G>A; p.P378P; 16:304424-304424	thyroid	carcinoma	Substitution - coding silent
c.568C>T; p.Q190*; 16:346458-346458	liver	carcinoma	Substitution - Nonsense
c.2109C>T; p.P703P; 16:293565-293565	skin	malignant_melanoma	Substitution - coding silent
c.230C>T; p.S77F; 16:346796-346796	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.142A>C; p.K48Q; 16:346884-346884	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.230C>T; p.S77F; 16:346796-346796	skin	malignant_melanoma	Substitution - Missense
c.230C>T; p.S77F; 16:346796-346796	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.1135A>T; p.K379*; 16:304423-304423	ovary	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.317T>G; p.L106R; 16:346709-346709	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1619A>G; p.H540R; 16:297887-297887	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.137C>T; p.S46F; 16:346889-346889	skin	malignant_melanoma	Substitution - Missense
c.1914delG; p.E640fs*65; 16:297097-297097	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2069_2070insT; p.Q691fs*91; 16:293604-293605	liver	carcinoma	Insertion - Frameshift
c.1577C>T; p.A526V; 16:297929-297929	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.182C>A; p.P61Q; 16:346844-346844	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1433T>G; p.V478G; 16:298073-298073	skin	malignant_melanoma	Substitution - Missense
c.1017C>T; p.S339S; 16:314545-314545	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2077C>T; p.P693S; 16:293597-293597	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2077C>T; p.P693S; 16:293597-293597	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.179C>T; p.T60I; 16:346847-346847	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.268C>T; p.H90Y; 16:346758-346758	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.2200G>T; p.V734F; 16:291284-291284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.943G>A; p.A315T; 16:314619-314619	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1145G>T; p.R382L; 16:304413-304413	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1734C>A; p.Y578*; 16:297772-297772	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2390G>A; p.R797H; 16:289512-289512	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.787C>T; p.P263S; 16:346239-346239	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.248_248delT; p.L83fs*1; 16:346778-346778	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1295delC; p.P432fs*48; 16:298211-298211	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.217G>A; p.E73K; 16:346809-346809	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.234delC; p.T79fs*5; 16:346792-346792	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.436C>T; p.R146*; 16:346590-346590	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.292G>A; p.G98R; 16:346734-346734	skin; ankle	malignant_melanoma; acral_lentiginous	Substitution - Missense
c.272_273CC>TT; p.S91F; 16:346753-346754	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2525A>G; p.E842G; 16:288186-288186	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.436C>T; p.R146*; 16:346590-346590	liver	carcinoma	Substitution - Nonsense
c.436C>T; p.R146*; 16:346590-346590	liver	carcinoma	Substitution - Nonsense
c.605T>C; p.L202P; 16:346421-346421	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2218G>A; p.A740T; 16:291266-291266	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1359C>T; p.D453D; 16:298147-298147	skin	carcinoma; Merkel_cell_carcinoma	Substitution - coding silent
c.396G>A; p.S132S; 16:346630-346630	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.741G>A; p.W247*; 16:346285-346285	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.741G>A; p.W247*; 16:346285-346285	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2218G>A; p.A740T; 16:291266-291266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1359C>T; p.D453D; 16:298147-298147	skin	carcinoma; Merkel_cell_carcinoma	Substitution - coding silent
c.1183_1186delCGCC; p.R395fs*18; 16:304372-304375	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1034C>T; p.P345L; 16:310055-310055	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1982C>T; p.P661L; 16:293692-293692	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.69C>T; p.P23P; 16:346957-346957	skin	malignant_melanoma	Substitution - coding silent
c.1982C>T; p.P661L; 16:293692-293692	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1058G>A; p.R353H; 16:310031-310031	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1851C>G; p.T617T; 16:297160-297160	liver	carcinoma	Substitution - coding silent
c.1058G>A; p.R353H; 16:310031-310031	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1902G>T; p.Q634H; 16:297109-297109	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1851C>G; p.T617T; 16:297160-297160	liver	carcinoma	Substitution - coding silent
c.862G>T; p.E288*; 16:346164-346164	liver	carcinoma	Substitution - Nonsense
c.862G>T; p.E288*; 16:346164-346164	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.698G>A; p.G233D; 16:346328-346328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1184G>C; p.R395P; 16:304374-304374	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1493delA; p.H498fs*207; 16:298013-298013	liver	carcinoma	Deletion - Frameshift
c.1528G>A; p.A510T; 16:297978-297978	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.677C>G; p.S226C; 16:346349-346349	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1396A>T; p.N466Y; 16:298110-298110	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.(1327_1353)del25; p.(A443)fs*?; 16:298179-298179	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.1206G>A; p.T402T; 16:304352-304352	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.1939C>T; p.R647C; 16:297072-297072	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1117-?_1254+?del138; p.?; 16:304304-304441	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.2524G>A; p.E842K; 16:288187-288187	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1371_1372insC; p.G458fs*11; 16:298134-298135	liver	carcinoma	Insertion - Frameshift
c.1977A>C; p.P659P; 16:293697-293697	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.2543C>T; p.P848L; 16:288168-288168	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.64C>T; p.R22*; 16:346962-346962	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2108C>T; p.P703L; 16:293566-293566	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1627A>G; p.T543A; 16:297879-297879	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1591C>A; p.H531N; 16:297915-297915	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1627A>G; p.T543A; 16:297879-297879	liver	carcinoma	Substitution - Missense
c.1831T>C; p.S611P; 16:297180-297180	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.2012A>G; p.E671G; 16:293662-293662	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.2012A>G; p.E671G; 16:293662-293662	breast	carcinoma	Substitution - Missense
c.178A>T; p.T60S; 16:346848-346848	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.254G>A; p.W85*; 16:346772-346772	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.1453C>T; p.Q485*; 16:298053-298053	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.1384G>A; p.A462T; 16:298122-298122	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.254G>A; p.W85*; 16:346772-346772	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2555A>G; p.E852G; 16:288156-288156	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.254G>A; p.W85*; 16:346772-346772	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.254G>A; p.W85*; 16:346772-346772	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.792C>T; p.P264P; 16:346234-346234	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.254G>A; p.W85*; 16:346772-346772	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Nonsense
c.254G>A; p.W85*; 16:346772-346772	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.717G>A; p.P239P; 16:346309-346309	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.808A>T; p.K270*; 16:346218-346218	liver	carcinoma	Substitution - Nonsense
c.808A>T; p.K270*; 16:346218-346218	liver	carcinoma	Substitution - Nonsense
c.2086C>A; p.P696T; 16:293588-293588	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1833G>T; p.S611S; 16:297178-297178	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.259G>T; p.E87*; 16:346767-346767	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.828T>C; p.A276A; 16:346198-346198	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1471C>T; p.H491Y; 16:298035-298035	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.644C>T; p.S215L; 16:346382-346382	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.337G>A; p.D113N; 16:346689-346689	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1171G>T; p.E391*; 16:304387-304387	liver	carcinoma	Substitution - Nonsense
c.562G>A; p.E188K; 16:346464-346464	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1549G>A; p.V517I; 16:297957-297957	liver	carcinoma	Substitution - Missense
c.1233G>T; p.E411D; 16:304325-304325	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1284G>A; p.S428S; 16:298222-298222	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1564G>A; p.A522T; 16:297942-297942	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1284G>A; p.S428S; 16:298222-298222	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1284G>A; p.S428S; 16:298222-298222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284G>A; p.S428S; 16:298222-298222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284G>A; p.S428S; 16:298222-298222	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1564G>A; p.A522T; 16:297942-297942	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1790_1791insA; p.V598fs*13; 16:297220-297221	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.410G>A; p.R137K; 16:346616-346616	thyroid	carcinoma; anaplastic_carcinoma	Substitution - Missense
c.793G>A; p.G265R; 16:346233-346233	liver	carcinoma	Substitution - Missense
c.793G>A; p.G265R; 16:346233-346233	liver	carcinoma	Substitution - Missense
c.962G>A; p.S321N; 16:314600-314600	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1393G>T; p.E465*; 16:298113-298113	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.2027delG; p.G676fs*29; 16:293647-293647	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.2212G>A; p.G738R; 16:291272-291272	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.645G>A; p.S215S; 16:346381-346381	breast	carcinoma	Substitution - coding silent
c.2067C>T; p.F689F; 16:293607-293607	breast	carcinoma	Substitution - coding silent
c.2527G>A; p.D843N; 16:288184-288184	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1180C>A; p.H394N; 16:304378-304378	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1457C>A; p.S486*; 16:298049-298049	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.646G>T; p.E216*; 16:346380-346380	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.302T>C; p.L101P; 16:346724-346724	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.446T>C; p.I149T; 16:346580-346580	breast	carcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]