| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8651 |
Name | SOCS1 |
Synonym | CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3;suppressor of cytokine signaling 1;SOCS1;suppressor of cytokine signaling 1 |
Definition | JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1 |
Position | 16p13.13 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 15514 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | JAK/STAT signaling pathway;PANTHER;P00038 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Type II diabetes mellitus;KEGG PATHWAY;hsa04930 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Disease | IMMUNE;GAD |
Disease | Celiac Disease;GAD |
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External Links |
|
Links to Entrez Gene | 8651 |
Links to all GeneRIF Items | 8651 |
Links to iHOP | 8651 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>8651 : length: 636 atggtagcacacaaccaggtggcagccgacaatgcagtctccacagcagcagagccccga cggcggccagaaccttcctcctcttcctcctcctcgcccgcggcccccgcgcgcccgcgg ccgtgccccgcggtcccggccccggcccccggcgacacgcacttccgcacattccgttcg cacgccgattaccggcgcatcacgcgcgccagcgcgctcctggacgcctgcggattctac tgggggcccctgagcgtgcacggggcgcacgagcggctgcgcgccgagcccgtgggcacc ttcctggtgcgcgacagccgccagcggaactgctttttcgcccttagcgtgaagatggcc tcgggacccacgagcatccgcgtgcactttcaggccggccgctttcacctggatggcagc cgcgagagcttcgactgcctcttcgagctgctggagcactacgtggcggcgccgcgccgc atgctgggggccccgctgcgccagcgccgcgtgcggccgctgcaggagctgtgccgccag cgcatcgtggccaccgtgggccgcgagaacctggctcgcatccccctcaaccccgtcctc cgcgactacctgagctccttccccttccagatttga |
Protein Sequence |
>8651 : length: 211 MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ RIVATVGRENLARIPLNPVLRDYLSSFPFQI |