Entrez Gene

Basic Information
Gene ID	8651
Name	SOCS1
Synonymous	CIS1\|CISH1\|JAB\|SOCS-1\|SSI-1\|SSI1\|TIP3;suppressor of cytokine signaling 1;SOCS1;suppressor of cytokine signaling 1
Definition	JAK binding protein\|JAK-binding protein\|STAT induced SH3 protein 1\|STAT-induced STAT inhibitor 1\|TIP-3\|Tec-interacting protein 3\|cytokine-inducible SH2 protein 1
Position	16p13.13
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
SOCS-1(h) + tec(h) <==> SOCS-1(h):tec(h) (binding)
SOCS-1(h) + Jak2(h) <==> SOCS-1(h):Jak2(h) (binding)
IGF-1R(m.s.) + SOCS-1(h) <==> IGF-1R(m.s.):SOCS-1(h) (binding)
SOCS-1(h) --/ IFNgamma(h) (decrease of abundance)
Murr1(h) + SOCS-1(h) <==> Murr1(h):SOCS-1(h) (binding)
SOCS-1(h) --> SOCS-1(h) (translocation)
SOCS-1(h) --/ IFNGR(h){p} (inhibition; decrease of phosphorylation)
SOCS-1(h) --/ STAT1(h){pY701} (inhibition; decrease of phosphorylation)
RasGAP(h) + SOCS-1(h) <==> RasGAP(h):SOCS-1(h) (binding)
ASK1(h) + SOCS-1(h) <==> ASK1(h):SOCS-1(h) (binding)
SOCS1(h) --> SOCS-1(h) (expression).
SOCS-1(h) --> SOCS-1(h) (translocation)
IFNgamma(h) --> SOCS-1(h) (increase of abundance)
ErbB1-p170(h){pY998} + SOCS-1(h) <==> ErbB1-p170(h){pY998}:SOCS-1(h) (binding)
ErbB2(h){pY1221}{pY1222} + SOCS-1(h) <==> ErbB2(h){pY1221}{pY1222}:SOCS-1(h) (binding)
ErbB3-isoform1(h) + SOCS-1(h) <==> ErbB3-isoform1(h):SOCS-1(h) (binding)
InsR(h) + SOCS-1(h) <==> InsR(h):SOCS-1(h) (binding)
SOCS-1(h) --> IRS-1(r){p} (decrease of phosphorylation)
SOCS-1(h) + ASK1(m.s.) <==> SOCS-1(h):ASK1(m.s.) (binding)
SOCS-1(h) + elongin C(m.s.) + elongin B(m.s.) <==> SOCS-1(h):elongin B(m.s.):elongin C(m.s.) (binding)
SOCS1(h) --> SOCS-1(h) (expression).
SOCS1(h) --> SOCS1(h) (expression).
hsa-miR-19a --/ SOCS1(h) (translational repression).
hsa-miR-19b --/ SOCS1(h) (translational repression).

Post Transcriptional Modification [Top]
	There is no record for SOCS1