| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 867 |
Name | CBL |
Synonym | C-CBL|CBL2|FRA11B|NSLL|RNF55;Cbl proto-oncogene, E3 ubiquitin protein ligase;CBL;Cbl proto-oncogene, E3 ubiquitin protein ligase |
Definition | Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal tra |
Position | 11q23.3 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 1372 |
TUSON P-value | 0.080258015 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | EGFR downregulation;PID Reactome;500515 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Paxillin-dependent events mediated by a4b1;PID Curated;200117 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Internalization of ErbB1;PID Curated;200146 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Notch signaling pathway;PID Curated;200013 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Stroke;FunDO |
Disease | Leukemia;FunDO |
Disease | Esotropia;FunDO |
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External Links |
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Links to Entrez Gene | 867 |
Links to all GeneRIF Items | 867 |
Links to iHOP | 867 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>867 : length: 2721 atggccggcaacgtgaagaagagctctggggccgggggcggcagcggctccgggggctcg ggttcgggtggcctgattgggctcatgaaggacgccttccagccgcaccaccaccaccac caccacctcagcccccacccgccggggacggtggacaagaagatggtggagaagtgctgg aagctcatggacaaggtggtgcggttgtgtcagaacccaaagctggcgctaaagaatagc ccaccttatatcttagacctgctaccagatacctaccagcatctccgtactatcttgtca agatatgaggggaagatggagacacttggagaaaatgagtattttagggtgtttatggag aatttgatgaagaaaactaagcaaaccataagcctcttcaaggagggaaaagaaagaatg tatgaggagaattctcagcctaggcgaaacctaaccaaactgtccctcatcttcagccac atgctggcagaactaaaaggaatctttccaagtggactctttcagggagacacatttcgg attactaaagcagatgctgcggaattttggagaaaagcttttggggaaaagacaatagtc ccttggaagagctttcgacaggctctacatgaagtgcatcccatcagttctgggctggag gccatggctctgaaatccactattgatctgacctgcaatgattatatttcggtttttgaa tttgacatctttacccgactctttcagccctggtcctctttgctcaggaattggaacagc cttgctgtaactcatcctggctacatggcttttttgacgtatgacgaagtgaaagctcgg ctccagaaattcattcacaaacctggcagttatatcttccggctgagctgtactcgtctg ggtcagtgggctattgggtatgttactgctgatgggaacattctccagacaatccctcac aataaacctctcttccaagcactgattgatggcttcagggaaggcttctatttgtttcct gatggacgaaatcagaatcctgatctgactggcttatgtgaaccaactccccaagaccat atcaaagtgacccaggaacaatatgaattatactgtgagatgggctccacattccaacta tgtaaaatatgtgctgaaaatgataaggatgtaaagattgagccctgtggacacctcatg tgcacatcctgtcttacatcctggcaggaatcagaaggtcagggctgtcctttctgccga tgtgaaattaaaggtactgaacccatcgtggtagatccgtttgatcctagagggagtggc agcctgttgaggcaaggagcagagggagctccctccccaaattatgatgatgatgatgat gaacgagctgatgatactctcttcatgatgaaggaattggctggtgccaaggtggaacgg ccgccttctccattctccatggccccacaagcttcccttcccccggtgccaccacgactt gaccttctgccgcagcgagtatgtgttccctcaagtgcttctgctcttggaactgcttct aaggctgcttctggctcccttcataaagacaaaccattgccagtacctcccacacttcga gatcttccaccaccaccgcctccagaccggccatattctgttggagcagaatcccgacct caaagacgccccttgccttgtacaccaggcgactgtccctccagagacaaactgccccct gtcccctctagccgccttggagactcatggctgccccggccaatccccaaagtaccagta tctgccccaagttccagtgatccctggacaggaagagaattaaccaaccggcactcactt ccattttcattgccctcacaaatggagcccagaccagatgtgcctaggctcggaagcacg ttcagtctggatacctccatgagtatgaatagcagcccattagtaggtccagagtgtgac caccccaaaatcaaaccttcctcatctgccaatgccatttattctctggctgccagacct cttcctgtgccaaaactgccacctggggagcaatgtgagggtgaagaggacacagagtac atgactccctcttccaggcctctacggcctttggatacatcccagagttcacgagcatgt gattgcgaccagcagattgatagctgtacgtatgaagcaatgtataatattcagtcccag gcgccatctatcaccgagagcagcacctttggtgaagggaatttggccgcagcccatgcc aacactggtcccgaggagtcagaaaatgaggatgatgggtatgatgtcccaaagccacct gtgccggccgtgctggcccgccgaactctctcagatatctctaatgccagctcctccttt ggctggttgtctctggatggtgatcctacaacaaatgtcactgaaggttcccaagttccc gagaggcctccaaaaccattcccgcggagaatcaactctgaacggaaagctggcagctgt cagcaaggtagtggtcctgccgcctctgctgccaccgcctcacctcagctctccagtgag atcgagaacctcatgagtcaggggtactcctaccaggacatccagaaagctttggtcatt gcccagaacaacatcgagatggccaaaaacatcctccgggaatttgtttccatttcttct cctgcccatgtagctacctag |
Protein Sequence |
>867 : length: 906 MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCW KLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFME NLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFR ITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFE FDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRL GQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR CEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVER PPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLR DLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPV SAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECD HPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRAC DCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPP VPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSC QQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISS PAHVAT |