| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 867 |
Name | CBL |
Synonymous | C-CBL|CBL2|FRA11B|NSLL|RNF55;Cbl proto-oncogene, E3 ubiquitin protein ligase;CBL;Cbl proto-oncogene, E3 ubiquitin protein ligase |
Definition | Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal tra |
Position | 11q23.3 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
c-Cbl(h) + SLAP(m) <==> c-Cbl(h):SLAP(m) (binding) | c-Cbl(h) + ZAP-70(h){p} <==> c-Cbl(h):ZAP-70(h){p} (binding) | c-Cbl(h) + ATP --> c-Cbl(h){pY} + ADP (phosphorylation) | c-Cbl(h) + Grb-2(h) <==> c-Cbl(h):Grb-2(h) (binding) | c-Cbl(h) + Grb-2(m) <==> c-Cbl(h):Grb-2(m) (binding) | CAP(m) + c-Cbl(h) <==> CAP(m):c-Cbl(h) (binding) | InsR(m){p} + APS(r){pY} + c-Cbl(h) <==> InsR(m){p}:APS(r){pY}:c-Cbl(h) (binding) | RANK(m) + c-Cbl(h) <==> RANK(m):c-Cbl(h) (binding) | c-Cbl(h) + UbcH7(h) <==> c-Cbl(h):UbcH7(h) (binding) | c-Cbl(h) + Sprouty2(h) <==> c-Cbl(h):Sprouty2(h) (binding) | c-Cbl(h) + Sprouty2(h){pY55} <==> c-Cbl(h):Sprouty2(h){pY55} (binding) | c-Cbl(h) + CIN85(h) <==> c-Cbl(h):CIN85(h) (binding) | 2 c-Cbl(h) + CIN85(h) <==> (c-Cbl(h))2:CIN85(h) (binding) | ErbB1(h) + c-Cbl(h) <==> ErbB1(h):c-Cbl(h) (binding) | c-Cbl(h) + CIN85(h):endophilin 1(h) <==> c-Cbl(h):CIN85(h):endophilin 1(h) (binding) | Fyn(m) + c-Cbl(h) <==> Fyn(m):c-Cbl(h) (binding) | c-Cbl(h) + ATP --Fyn(r)--> c-Cbl(h){pY731} + ADP (phosphorylation) | Lck(m) + c-Cbl(h) <==> Lck(m):c-Cbl(h) (binding) | c-Cbl(h) + ATP --> c-Cbl(h){pT} + ADP (phosphorylation) | EPHB6(h) + c-Cbl(h) <==> EPHB6(h):c-Cbl(h) (binding) | EPHB6(h) + c-Cbl(h) <==> EPHB6(h):c-Cbl(h) (increase of dephosphorylation; binding) | c-Cbl(h) --> Syk(m.s.){ub} (decrease of abundance; increase of ubiquitination) | c-Cbl(h) + NTP --SykA(m.s.)--> c-Cbl(h){pY700}{pY731}{pY774} + NDP (phosphorylation) | c-Cbl(h) + NTP --SykB(m.s.)--> c-Cbl(h){pY700}{pY731}{pY774} + NDP (phosphorylation) | CrkL(h){pY} + c-Cbl(h) <==> CrkL(h){pY}:c-Cbl(h) (binding) | c-Cbl(h) + CrkL(h) <==> c-Cbl(h):CrkL(h) (binding) | crk(h) + c-Cbl(h) <==> crk(h):c-Cbl(h) (binding) | c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation) | c-Cbl(h) + PKCalpha(h) <==> c-Cbl(h):PKCalpha(h) (binding) | c-Cbl(h) + ATP --PKCtheta(h)--> c-Cbl(h){p} + ADP (phosphorylation) | PKCtheta(h) + c-Cbl(h) <==> PKCtheta(h):c-Cbl(h) (binding) | c-Cbl(h) + SLP-76(h) <==> c-Cbl(h):SLP-76(h) (binding) | c-Cbl(h) + Cool-1(h) <==> c-Cbl(h):Cool-1(h) (binding) | c-Cbl(h) + CrkL(m.s.) <==> c-Cbl(h):CrkL(m.s.) (binding) | crkII(h) + c-Cbl(h) <==> crkII(h):c-Cbl(h) (binding) | Crk-II(m.s.) + c-Cbl(h) <==> Crk-II(m.s.):c-Cbl(h) (binding) | c-Cbl(h) + p85(h) <==> c-Cbl(h):p85(h) (binding) | c-Cbl(h) + Fyn(h) <==> c-Cbl(h):Fyn(h) (binding) | Fyn-isoform1(h) + c-Cbl(h) <==> Fyn-isoform1(h):c-Cbl(h) (binding) | c-Cbl(h) + Fyn-isoform2(m) <==> c-Cbl(h):Fyn-isoform2(m) (binding) | ErbB1(h){pY} + c-Cbl(h) <==> ErbB1(h){pY}:c-Cbl(h) (binding) | c-Cbl(h) + p85(m.s.) <==> c-Cbl(h):p85(m.s.) (binding) | c-Cbl(h) + Src(h) <==> c-Cbl(h):Src(h) (binding) | c-Cbl(h) --> c-Cbl(h) (translocation) | c-Cbl(h) + 2 ATP --> c-Cbl(h){pY}2 + 2 ADP (phosphorylation) | c-Cbl(h) + CrkL(h) + Grb-2(h) <==> c-Cbl(h):CrkL(h):Grb-2(h) (binding) | c-Cbl(h) + n ATP --> c-Cbl(h){pY}n + n ADP (phosphorylation) | NCK(h) + c-Cbl(h) <==> NCK(h):c-Cbl(h) (binding) | c-Cbl(h) --> c-Cbl(h) (translocation) | alk(h) + c-Cbl(h) <==> alk(h):c-Cbl(h) (binding) | c-Cbl(h) + ATP --> c-Cbl(h){pY774} + ADP (phosphorylation) | c-Cbl(h) + Sts2(m.s.) <==> c-Cbl(h):Sts2(m.s.) (binding) | Nck-1(m.s.) + c-Cbl(h) <==> Nck-1(m.s.):c-Cbl(h) (binding) | c-Cbl(h) + ATP --> c-Cbl(h){pY731} + ADP (phosphorylation) | c-Cbl(h) + Rac1(h) <==> c-Cbl(h):Rac1(h) (binding) | CBL(h) --> c-Cbl(h) (expression). | NEDD4-1(m.s.) --> c-Cbl(h) (decrease of abundance) | EGF(m.s.) --/ c-Cbl(h) (decrease of abundance) | c-Cbl(h) --> c-Cbl(h) (translocation) | c-Cbl(h){pY}2 --> c-Cbl(h) + 2 ATP (dephosphorylation) | c-Cbl(h){pY} --> c-Cbl(h) + ATP (dephosphorylation) | c-Cbl(h) --> c-Cbl(h) (translocation) | ErbB1(h) + ubiquitin(h) --c-Cbl(h),UbcH7(h)--> ErbB1(h){ub} (ubiquitination) | fgfr1(h) + ubiquitin(h) --c-Cbl(h)--> fgfr1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | CIN85(h) + ubiquitin(v.s.) --c-Cbl(h)--> CIN85(h){ub(1)} (ubiquitination) | PDGFRbeta(v.s.) + ubiquitin(v.s.) --c-Cbl(h)--> PDGFRbeta(v.s.){ub(1)}{ub(1)} (ubiquitination) | ErbB1(h) + 2 ubiquitin(v.s.) --c-Cbl(h)--> ErbB1(h){ub(1)}{ub(1)} (ubiquitination) | FcgammaRIIA(h) + ubiquitin(h) --c-Cbl(h)--> FcgammaRIIA(h){ub} (ubiquitination) | c-Cbl(h) + ATP --PKCtheta(h)--> c-Cbl(h){p} + ADP (phosphorylation) | c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation) | PKCalpha(h) + c-Cbl(h) <==> PKCalpha(h):c-Cbl(h) (binding) | PKCtheta(h) + c-Cbl(h) <==> PKCtheta(h):c-Cbl(h) (binding) | C3G(h) + c-Cbl(h) <==> C3G(h):c-Cbl(h) (binding) | c-Cbl(h) + ErbB1(mo) <==> c-Cbl(h):ErbB1(mo) (binding) | 2 c-Cbl(h) <==> (c-Cbl(h))2 (binding; oligomerization) | Cbl-b(m.s.) + c-Cbl(h) <==> Cbl-b(m.s.):c-Cbl(h) (binding) | c-Cbl(h) + ATP --> c-Cbl(h){pY} + ADP (phosphorylation) | STS-1(m.s.) + c-Cbl(h) <==> STS-1(m.s.):c-Cbl(h) (binding) | Sts2(m.s.) + c-Cbl(h) <==> Sts2(m.s.):c-Cbl(h) (binding) | c-Cbl(h) + c-Kit(h){pY568}{pY936} <==> c-Cbl(h):c-Kit(h){pY568}{pY936} (binding) | c-Cbl(h) + c-Kit(h) <==> c-Cbl(h):c-Kit(h) (binding) | c-Cbl(h) + Grb-2(m) <==> c-Cbl(h):Grb-2(m) (binding) | FRS2alpha(m){pY196} + c-Cbl(h) <==> FRS2alpha(m){pY196}:c-Cbl(h) (binding) | CBL(h) --> c-Cbl(h) (expression). | ErbB1(h) + ubiquitin(h) --c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --c-Cbl(h),Ubc5B(h),E1(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --E1(h),Ubc5C(h),c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | c-Met(m.s.) + ubiquitin(h) --c-Cbl(h)--> c-Met(m.s.){ub} (ubiquitination) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
371 | Phosphotyrosine (by INSR). | Swiss-Prot 53.0 | 552 | Phosphotyrosine. | Swiss-Prot 53.0 | 667 | Phosphoserine. | Swiss-Prot 53.0 | 669 | Phosphoserine. | Swiss-Prot 53.0 | 674 | Phosphotyrosine. | Swiss-Prot 53.0 | 675 | Phosphoserine. | Swiss-Prot 53.0 | 700 | Phosphotyrosine. | Swiss-Prot 53.0 | 774 | Phosphotyrosine. | Swiss-Prot 53.0 | 900 | Phosphoserine. | Swiss-Prot 53.0 | 731 | Phosphotyrosine (Fyn;Lck;Syk;) | 9525940;10934191;9890970;12604776 | Phospho.ELM 6.0 | 700 | Phosphotyrosine (Fyn;Lck;Abl;) | 9525940;9102067;12522270;11997497;10829062 | Phospho.ELM 6.0 | 371 | Phosphotyrosine (EGFR;InsR) | 10635327;11997497 | Phospho.ELM 6.0 | 774 | Phosphotyrosine (Fyn;Lck;Abl;) | 12522270;12604776;10829062 | Phospho.ELM 6.0 | 774 | Phosphotyrosine (Fyn;Syk;Yes) | 9525940;12522270 | Phospho.ELM 6.0 | 674 | Phosphotyrosine | 12522270;15144186;15592455 | Phospho.ELM 6.0 | 669 | Phosphoserine | 12522270;15144186 | Phospho.ELM 6.0 | 337 | Phosphotyrosine | 10608804 | Phospho.ELM 6.0 | 667 | Phosphoserine | 16094384 | Phospho.ELM 6.0 | 675 | Phosphoserine | 16094384 | Phospho.ELM 6.0 | 368 | Phosphotyrosine | 15117950 | Phospho.ELM 6.0 | 552 | Phosphotyrosine | 15951569 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr11 |
Promoter: 118580700 - 118582700 | Agilent_014791 |
chr11 |
Promoter: 118580700 - 118582700 | GSE27584 |
chr11 |
Promoter: 118580700 - 118582700 | Agilent_014791_44K |