Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9021

Name

SOCS3

Synonym

ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3;suppressor of cytokine signaling 3;SOCS3;suppressor of cytokine signaling 3

Definition

STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3

Position

17q25.3

Gene Type

protein-coding

TSG scores

Description

TUSON ranking

15516

TUSON P-value

1

Pathways and Diseases

Pathway

Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920

Pathway

Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

IL4-mediated signaling events;PID Curated;200018

Pathway

il-2 receptor beta chain in t cell activation;PID BioCarta;100129

Pathway

EPO signaling pathway;PID Curated;200157

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120

Pathway

il22 soluble receptor signaling pathway;PID BioCarta;100131

Pathway

IL23-mediated signaling events;PID Curated;200131

Pathway

Interferon-gamma signaling pathway;PANTHER;P00035

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

IL6-mediated signaling events;PID Curated;200124

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

ATF-2 transcription factor network;PID Curated;200116

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Type II diabetes mellitus;KEGG PATHWAY;hsa04930

Disease

Tuberculosis;FunDO

Disease

Prostate cancer;FunDO

Disease

Metastasis to lymph nodes;FunDO

Disease

Dermatitis, atopic, susceptibility to, 4;OMIM

Disease

Liver tumor;FunDO

Disease

Polycystic ovary syndrome;FunDO

Disease

Lung cancer;FunDO

Disease

Obesity;FunDO

Disease

Leukemia;FunDO

Disease

Melanoma;FunDO

Disease

Polyarthritis;FunDO

Disease

Uveitis;FunDO

Disease

Breast cancer;FunDO

Disease

Adenovirus infection;FunDO

Disease

Cervical cancer;FunDO

Disease

Ulcerative colitis;FunDO

Disease

Cholangiocarcinoma;FunDO

External Links

Links to Entrez Gene

9021

Links to all GeneRIF Items

9021

Links to iHOP

9021

Sequence Information

The sequences provided here are only the longest representative sequences, not covering all the isoforms.

Nucleotide Sequence

>9021 : length: 678
atggtcacccacagcaagtttcccgccgccgggatgagccgccccctggacaccagcctg
cgcctcaagaccttcagctccaagagcgagtaccagctggtggtgaacgcagtgcgcaag
ctgcaggagagcggcttctactggagcgcagtgaccggcggcgaggcgaacctgctgctc
agtgccgagcccgccggcacctttctgatccgcgacagctcggaccagcgccacttcttc
acgctcagcgtcaagacccagtctgggaccaagaacctgcgcatccagtgtgaggggggc
agcttctctctgcagagcgatccccggagcacgcagcccgtgccccgcttcgactgcgtg
ctcaagctggtgcaccactacatgccgccccctggagccccctccttcccctcgccacct
actgaaccctcctccgaggtgcccgagcagccgtctgcccagccactccctgggagtccc
cccagaagagcctattacatctactccgggggcgagaagatccccctggtgttgagccgg
cccctctcctccaacgtggccactcttcagcatctctgtcggaagaccgtcaacggccac
ctggactcctatgagaaagtcacccagctgccggggcccattcgggagttcctggaccag
tacgatgccccgctttaa

Protein Sequence

>9021 : length: 225
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL



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