Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9021

Name

SOCS3

Synonymous

ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3;suppressor of cytokine signaling 3;SOCS3;suppressor of cytokine signaling 3

Definition

STAT-induced STAT inhibitor 3|cytokine-inducible SH2 protein 3

Position

17q25.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 EPORNCI_NATURE;

in same component

 EPONCI_NATURE;

in same component

 IL12BNCI_NATURE;

in same component

 IL12RB1NCI_NATURE;

in same component

 IL23ANCI_NATURE;

in same component

 IL23RNCI_NATURE;

in same component

 IL2RBNCI_NATURE;

in same component

 IL6RNCI_NATURE;

in same component

 IL6NCI_NATURE;

in same component

 IL6STNCI_NATURE;

in same component

 JAK1NCI_NATURE;

in same component

 JAK2NCI_NATURE;

in same component

 LCKNCI_NATURE;

in same component

 RASA1NCI_NATURE;

in same component

 SOCS2NCI_NATURE;

in same component

 TYK2NCI_NATURE;

interacts with

 BCL10HPRD;

interacts with

 CSF1RBIOGRID;

interacts with

 CSF3RHPRD;

interacts with

 CSNK1EHPRD;

interacts with

 CXCR4BIOGRID;

interacts with

 CXCR4HPRD;

interacts with

 EGFRBIOGRID;

interacts with

 EGFRCELL_MAP;

interacts with

 EGFRHPRD;

interacts with

 EPORBIOGRID;

interacts with

 EPORHPRD;

interacts with

 EPORMINT;

interacts with

 GHRBIOGRID;

interacts with

 GHRHPRD;

interacts with

 IGF1RBIOGRID;

interacts with

 IGF1RHPRD;

interacts with

 IL12RB2MINT;

interacts with

 IL2RBHPRD;

interacts with

 IL6STBIOGRID;

interacts with

 IL6STHPRD;

interacts with

 INSRBIOGRID;

interacts with

 INSRHPRD;

interacts with

 IRS1HPRD;

interacts with

 IRS2HPRD;

interacts with

 JAK1HPRD;

interacts with

 JAK2BIOGRID;

interacts with

 JAK2HPRD;

interacts with

 JAK2MINT;

interacts with

 JAK3HPRD;

interacts with

 LEPRBIOGRID;

interacts with

 LEPRHPRD;

interacts with

 MAP1SMINT;

interacts with

 MAP3K5BIOGRID;

interacts with

 MAP3K7BIOGRID;

interacts with

 NONOBIOGRID;

interacts with

 PIN1BIOGRID;

interacts with

 PIN1HPRD;

interacts with

 PIN1MINT;

interacts with

 PPP3CBHPRD;

interacts with

 PRLRBIOGRID;

interacts with

 PRLRHPRD;

interacts with

 PTK2BBIOGRID;

interacts with

 PTPN11BIOGRID;

interacts with

 PTPN11HPRD;

interacts with

 RASA1BIOGRID;

interacts with

 RASA1CELL_MAP;

interacts with

 RASA1HPRD;

interacts with

 RASA1MINT;

interacts with

 SOCS2HPRD;

interacts with

 TCEB1HPRD;

interacts with

 TCEB2HPRD;

interacts with

 TRAF6BIOGRID;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 ATF2NCI_NATURE;

metabolic catalysis

 IL2RANCI_NATURE;

metabolic catalysis

 IL2RBNCI_NATURE;

metabolic catalysis

 IL2RGNCI_NATURE;

metabolic catalysis

 IL2NCI_NATURE;

metabolic catalysis

 JAK1NCI_NATURE;

metabolic catalysis

 JAK2NCI_NATURE;

metabolic catalysis

 JAK3NCI_NATURE;

metabolic catalysis

 LCKNCI_NATURE;

metabolic catalysis

 LEPRNCI_NATURE;

metabolic catalysis

 MAPK14NCI_NATURE;

metabolic catalysis

 STAT3NCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 EPORNCI_NATURE;

reacts with

 EPONCI_NATURE;

reacts with

 IL12BNCI_NATURE;

reacts with

 IL12RB1NCI_NATURE;

reacts with

 IL23ANCI_NATURE;

reacts with

 IL23RNCI_NATURE;

reacts with

 IL2RBNCI_NATURE;

reacts with

 IL6RNCI_NATURE;

reacts with

 IL6NCI_NATURE;

reacts with

 IL6STNCI_NATURE;

reacts with

 JAK1NCI_NATURE;

reacts with

 JAK2NCI_NATURE;

reacts with

 LCKNCI_NATURE;

reacts with

 RASA1NCI_NATURE;

reacts with

 SOCS2NCI_NATURE;

reacts with

 SOCS3NCI_NATURE;

reacts with

 SOCS3REACTOME;

reacts with

 TYK2NCI_NATURE;

state change

 IL2RANCI_NATURE;

state change

 IL2RBNCI_NATURE;

state change

 IL2RGNCI_NATURE;

state change

 IL2NCI_NATURE;

state change

 JAK1NCI_NATURE;

state change

 JAK3NCI_NATURE;

state change

 LCKNCI_NATURE;

state change

 PTPN6NCI_NATURE;

state change

 SH2B3NCI_NATURE;

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