Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1634

Name

DCN

Synonymous

decorin;DCN;decorin

Definition

PG-S2|bone proteoglycan II|decorin proteoglycan|dermatan sulphate proteoglycans II|proteoglycan core protein|small leucine-rich protein 1B

Position

12q21.33

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.14.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.661C>T; p.P221S; 12:91153181-91153181

 skinmalignant_melanomaSubstitution - Missense

c.661C>T; p.P221S; 12:91153181-91153181

 skinmalignant_melanomaSubstitution - Missense

c.2T>C; p.M1T; 12:91178551-91178551

 skin; armmalignant_melanomaSubstitution - Missense

c.296G>A; p.G99E; 12:91164633-91164633

 skinmalignant_melanomaSubstitution - Missense

c.1066G>A; p.G356R; 12:91146072-91146072

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1066G>A; p.G356R; 12:91146072-91146072

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.616C>T; p.R206C; 12:91157111-91157111

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.46G>A; p.A16T; 12:91178507-91178507

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.593G>A; p.G198E; 12:91157134-91157134

 skinmalignant_melanomaSubstitution - Missense

c.699C>T; p.I233I; 12:91153143-91153143

 skinmalignant_melanomaSubstitution - coding silent

c.673G>A; p.E225K; 12:91153169-91153169

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.447C>T; p.P149P; 12:91158387-91158387

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.442_443insA; p.M148fs*12; 12:91158391-91158392

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.486C>T; p.I162I; 12:91158348-91158348

 skinmalignant_melanomaSubstitution - coding silent

c.532G>A; p.V178I; 12:91158302-91158302

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.623C>T; p.A208V; 12:91157104-91157104

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.765C>A; p.N255K; 12:91151774-91151774

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.653-2A>G; p.?; 12:91153191-91153191

 livercarcinoma; hepatocellular_carcinomaUnknown

c.49G>A; p.G17R; 12:91178504-91178504

 skinmalignant_melanomaSubstitution - Missense

c.420G>T; p.Q140H; 12:91158414-91158414

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 skinmalignant_melanomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.283G>A; p.E95K; 12:91164646-91164646

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.195C>T; p.V65V; 12:91178358-91178358

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.693C>T; p.N231N; 12:91153149-91153149

 central_nervous_system; braingliomaSubstitution - coding silent

c.138C>T; p.F46F; 12:91178415-91178415

 skinmalignant_melanomaSubstitution - coding silent

c.923G>C; p.G308A; 12:91146215-91146215

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.449A>C; p.K150T; 12:91158385-91158385

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.497G>A; p.R166Q; 12:91158337-91158337

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.29T>C; p.L10P; 12:91178524-91178524

 skinmalignant_melanomaSubstitution - Missense

c.127G>T; p.D43Y; 12:91178426-91178426

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.205G>A; p.D69N; 12:91178348-91178348

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.860G>A; p.G287E; 12:91151679-91151679

 skinmalignant_melanomaSubstitution - Missense

c.541C>A; p.L181M; 12:91157186-91157186

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.397C>T; p.R133*; 12:91158437-91158437

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.397C>T; p.R133*; 12:91158437-91158437

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Nonsense

c.1048C>T; p.R350C; 12:91146090-91146090

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.630C>A; p.T210T; 12:91157097-91157097

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.641G>A; p.S214N; 12:91157086-91157086

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.974C>T; p.S325L; 12:91146164-91146164

 skinmalignant_melanomaSubstitution - Missense

c.244G>C; p.D82H; 12:91164685-91164685

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.612C>T; p.Y204Y; 12:91157115-91157115

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1011G>A; p.W337*; 12:91146127-91146127

 skinmalignant_melanomaSubstitution - Nonsense

c.1003C>T; p.Q335*; 12:91146135-91146135

 skinmalignant_melanomaSubstitution - Nonsense

c.671C>T; p.T224M; 12:91153171-91153171

 central_nervous_system; braingliomaSubstitution - Missense

c.671C>T; p.T224M; 12:91153171-91153171

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.671C>T; p.T224M; 12:91153171-91153171

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.514G>A; p.G172R; 12:91158320-91158320

 skinmalignant_melanomaSubstitution - Missense

c.324+1G>T; p.?; 12:91164604-91164604

 lungcarcinoma; adenocarcinomaUnknown

c.427G>A; p.E143K; 12:91158407-91158407

 skinmalignant_melanomaSubstitution - Missense

c.901A>G; p.N301D; 12:91146237-91146237

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1032C>G; p.F344L; 12:91146106-91146106

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1032C>G; p.F344L; 12:91146106-91146106

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1029C>T; p.T343T; 12:91146109-91146109

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1007A>T; p.Y336F; 12:91146131-91146131

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.399A>G; p.R133R; 12:91158435-91158435

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.399A>G; p.R133R; 12:91158435-91158435

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.399A>G; p.R133R; 12:91158435-91158435

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.882C>T; p.I294I; 12:91151657-91151657

 skinmalignant_melanomaSubstitution - coding silent

c.187C>T; p.R63*; 12:91178366-91178366

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.426G>T; p.K142N; 12:91158408-91158408

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.597G>T; p.M199I; 12:91157130-91157130

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.3G>A; p.M1I; 12:91178550-91178550

 skinmalignant_melanomaSubstitution - Missense

c.878A>G; p.Y293C; 12:91151661-91151661

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.606C>A; p.L202L; 12:91157121-91157121

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.912C>T; p.I304I; 12:91146226-91146226

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.131G>A; p.R44H; 12:91178422-91178422

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.706G>T; p.V236F; 12:91153136-91153136

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.706G>T; p.V236F; 12:91153136-91153136

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.912C>A; p.I304I; 12:91146226-91146226

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.640A>T; p.S214C; 12:91157087-91157087

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.650A>G; p.Q217R; 12:91157077-91157077

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.650A>G; p.Q217R; 12:91157077-91157077

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1032C>T; p.F344F; 12:91146106-91146106

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.466C>T; p.R156C; 12:91158368-91158368

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1048C>A; p.R350S; 12:91146090-91146090

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.322C>T; p.H108Y; 12:91164607-91164607

 skinmalignant_melanomaSubstitution - Missense

c.24_26delTCT; p.L10delL; 12:91178527-91178529

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - In frame

c.265C>T; p.Q89*; 12:91164664-91164664

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.833A>G; p.N278S; 12:91151706-91151706

 skinmalignant_melanomaSubstitution - Missense

c.76G>T; p.D26Y; 12:91178477-91178477

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.288C>A; p.I96I; 12:91164641-91164641

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.1045G>A; p.V349M; 12:91146093-91146093

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.860G>T; p.G287V; 12:91151679-91151679

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.52C>T; p.P18S; 12:91178501-91178501

 skinmalignant_melanomaSubstitution - Missense

c.1077_1080delGTAA; p.K359fs?; 12:91146058-91146061

 endometriumcarcinoma; endometrioid_carcinomaDeletion - Frameshift

c.665C>T; p.S222F; 12:91153177-91153177

 skinmalignant_melanomaSubstitution - Missense

c.1049G>A; p.R350H; 12:91146089-91146089

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.530T>C; p.I177T; 12:91158304-91158304

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.530T>C; p.I177T; 12:91158304-91158304

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.731T>C; p.L244P; 12:91153111-91153111

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.569G>A; p.G190E; 12:91157158-91157158

 breastcarcinomaSubstitution - Missense

c.135C>G; p.D45E; 12:91178418-91178418

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.425A>C; p.K142T; 12:91158409-91158409

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.176A>G; p.Q59R; 12:91178377-91178377

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.502G>A; p.V168I; 12:91158332-91158332

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.523C>T; p.Q175*; 12:91158311-91158311

 skinmalignant_melanomaSubstitution - Nonsense

c.121C>T; p.P41S; 12:91178432-91178432

 skinmalignant_melanomaSubstitution - Missense

c.662C>A; p.P221H; 12:91153180-91153180

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.325G>A; p.A109T; 12:91158509-91158509

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; chronic_myeloid_leukaemiaSubstitution - Missense

c.325G>A; p.A109T; 12:91158509-91158509

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; chronic_myeloid_leukaemiaSubstitution - Missense

c.51A>C; p.G17G; 12:91178502-91178502

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.852A>G; p.V284V; 12:91151687-91151687

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.912C>G; p.I304M; 12:91146226-91146226

 breastcarcinomaSubstitution - Missense

c.534C>T; p.V178V; 12:91158300-91158300

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.659C>A; p.P220H; 12:91153183-91153183

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.430T>A; p.L144M; 12:91158404-91158404

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.149T>A; p.L50Q; 12:91178404-91178404

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.300C>A; p.D100E; 12:91164629-91164629

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.283G>T; p.E95*; 12:91164646-91164646

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaSubstitution - Nonsense

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