Entrez Gene

Basic Information
Gene ID	219699
Name	UNC5B
Synonymous	unc-5 homolog B (C. elegans);UNC5B;unc-5 homolog B (C. elegans)
Definition	netrin receptor UNC5B\|p53-regulated receptor for death and life protein 1\|protein unc-5 homolog 2\|protein unc-5 homolog B\|transmembrane receptor Unc5H2\|unc-5 homolog 2
Position	10q22.1
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1735G>A; p.E579K; 10:71292517-71292517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.684G>C; p.K228N; 10:71286820-71286820	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.844G>A; p.G282R; 10:71287708-71287708	lung; left_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1029C>T; p.L343L; 10:71288695-71288695	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2088G>T; p.Q696H; 10:71293846-71293846	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1265A>C; p.H422P; 10:71291080-71291080	breast	carcinoma	Substitution - Missense
c.1291C>T; p.P431S; 10:71291106-71291106	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2433C>T; p.C811C; 10:71296685-71296685	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.817T>G; p.C273G; 10:71287681-71287681	central_nervous_system; brain	glioma	Substitution - Missense
c.1121C>T; p.A374V; 10:71290936-71290936	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1621C>A; p.P541T; 10:71291758-71291758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1621C>A; p.P541T; 10:71291758-71291758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2415delG; p.E805fs*66; 10:71296667-71296667	skin; neck	malignant_melanoma	Deletion - Frameshift
c.1621C>A; p.P541T; 10:71291758-71291758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.749_750CC>TT; p.S250F; 10:71287613-71287614	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2101G>A; p.A701T; 10:71293859-71293859	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.428G>A; p.R143Q; 10:71284843-71284843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2274C>T; p.L758L; 10:71295909-71295909	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.173A>G; p.Y58C; 10:71279914-71279914	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.776C>A; p.S259Y; 10:71287640-71287640	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1290G>A; p.R430R; 10:71291105-71291105	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2176-4A>G; p.?; 10:71295807-71295807	liver	carcinoma	Unknown
c.684G>A; p.K228K; 10:71286820-71286820	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.2176-4A>G; p.?; 10:71295807-71295807	liver	carcinoma	Unknown
c.684G>A; p.K228K; 10:71286820-71286820	thyroid	carcinoma; anaplastic_carcinoma	Substitution - coding silent
c.2094C>G; p.A698A; 10:71293852-71293852	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284G>C; p.T428T; 10:71291099-71291099	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.351G>A; p.V117V; 10:71284766-71284766	skin	malignant_melanoma	Substitution - coding silent
c.678G>A; p.V226V; 10:71286814-71286814	skin	malignant_melanoma	Substitution - coding silent
c.1847G>A; p.R616H; 10:71293479-71293479	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1811C>T; p.S604L; 10:71293443-71293443	skin	malignant_melanoma	Substitution - Missense
c.262C>T; p.Q88*; 10:71280003-71280003	liver	carcinoma	Substitution - Nonsense
c.829G>A; p.A277T; 10:71287693-71287693	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.829G>A; p.A277T; 10:71287693-71287693	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.758C>T; p.A253V; 10:71287622-71287622	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1545C>T; p.F515F; 10:71291682-71291682	skin	malignant_melanoma	Substitution - coding silent
c.2823C>T; p.T941T; 10:71299262-71299262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1479G>C; p.G493G; 10:71291616-71291616	breast	carcinoma	Substitution - coding silent
c.2823C>T; p.T941T; 10:71299262-71299262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1134G>T; p.A378A; 10:71290949-71290949	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2475T>C; p.H825H; 10:71296727-71296727	thyroid	other; neoplasm	Substitution - coding silent
c.1345G>A; p.A449T; 10:71291482-71291482	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.876G>T; p.K292N; 10:71287740-71287740	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2375G>C; p.C792S; 10:71296627-71296627	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.170C>T; p.A57V; 10:71279911-71279911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2718C>T; p.I906I; 10:71299157-71299157	skin	malignant_melanoma	Substitution - coding silent
c.339G>A; p.S113S; 10:71284754-71284754	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2305A>G; p.K769E; 10:71295940-71295940	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.339G>A; p.S113S; 10:71284754-71284754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2232G>T; p.P744P; 10:71295867-71295867	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.741C>T; p.G247G; 10:71287605-71287605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1114G>T; p.G372W; 10:71290929-71290929	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.878C>T; p.T293I; 10:71287742-71287742	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2582C>T; p.S861F; 10:71298000-71298000	skin	malignant_melanoma	Substitution - Missense
c.2100C>T; p.F700F; 10:71293858-71293858	skin	malignant_melanoma	Substitution - coding silent
c.171C>A; p.A57A; 10:71279912-71279912	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2100C>T; p.F700F; 10:71293858-71293858	skin	malignant_melanoma	Substitution - coding silent
c.1905T>A; p.F635L; 10:71293537-71293537	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1787G>A; p.G596E; 10:71293419-71293419	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.612C>T; p.L204L; 10:71286748-71286748	breast	carcinoma	Substitution - coding silent
c.1879G>A; p.E627K; 10:71293511-71293511	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1594C>T; p.Q532*; 10:71291731-71291731	skin	malignant_melanoma	Substitution - Nonsense
c.2184G>A; p.L728L; 10:71295819-71295819	skin	malignant_melanoma	Substitution - coding silent
c.1122G>A; p.A374A; 10:71290937-71290937	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1731C>A; p.F577L; 10:71292513-71292513	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2449delG; p.E818fs*53; 10:71296701-71296701	skin	malignant_melanoma	Deletion - Frameshift
c.2731G>A; p.E911K; 10:71299170-71299170	skin; neck	malignant_melanoma	Substitution - Missense
c.871C>T; p.Q291*; 10:71287735-71287735	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1505T>A; p.L502Q; 10:71291642-71291642	liver	carcinoma	Substitution - Missense
c.2785G>A; p.E929K; 10:71299224-71299224	skin	malignant_melanoma	Substitution - Missense
c.1505T>A; p.L502Q; 10:71291642-71291642	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.372G>A; p.E124E; 10:71284787-71284787	skin	malignant_melanoma	Substitution - coding silent
c.2065C>A; p.R689S; 10:71293823-71293823	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.965G>T; p.R322L; 10:71288631-71288631	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2336T>G; p.F779C; 10:71296588-71296588	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.465C>T; p.F155F; 10:71285342-71285342	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.360C>A; p.L120L; 10:71284775-71284775	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1739T>A; p.M580K; 10:71292521-71292521	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2160G>A; p.T720T; 10:71293918-71293918	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1914G>C; p.K638N; 10:71293546-71293546	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2160G>A; p.T720T; 10:71293918-71293918	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - coding silent
c.166G>A; p.D56N; 10:71279907-71279907	skin	malignant_melanoma	Substitution - Missense
c.1210C>G; p.R404G; 10:71291025-71291025	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.812G>A; p.R271Q; 10:71287676-71287676	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.237C>A; p.F79L; 10:71279978-71279978	skin	malignant_melanoma	Substitution - Missense
c.1633G>A; p.V545I; 10:71291770-71291770	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2739G>A; p.L913L; 10:71299178-71299178	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1210C>G; p.R404G; 10:71291025-71291025	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1633G>A; p.V545I; 10:71291770-71291770	stomach	adenocarcinoma	Substitution - Missense
c.782G>T; p.R261L; 10:71287646-71287646	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1563C>T; p.F521F; 10:71291700-71291700	skin	malignant_melanoma	Substitution - coding silent
c.1563C>T; p.F521F; 10:71291700-71291700	skin	malignant_melanoma	Substitution - coding silent
c.1563C>T; p.F521F; 10:71291700-71291700	skin	malignant_melanoma	Substitution - coding silent
c.1638C>T; p.S546S; 10:71291775-71291775	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2429T>A; p.I810N; 10:71296681-71296681	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1267C>T; p.P423S; 10:71291082-71291082	skin	malignant_melanoma	Substitution - Missense
c.424C>T; p.R142C; 10:71284839-71284839	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1137G>A; p.G379G; 10:71290952-71290952	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.531G>A; p.P177P; 10:71285408-71285408	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1892G>A; p.R631H; 10:71293524-71293524	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1324C>T; p.P442S; 10:71291461-71291461	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2628G>A; p.R876R; 10:71298046-71298046	skin	malignant_melanoma	Substitution - coding silent
c.2212T>G; p.L738V; 10:71295847-71295847	skin	malignant_melanoma	Substitution - Missense
c.288C>T; p.G96G; 10:71280029-71280029	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.288C>T; p.G96G; 10:71280029-71280029	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2626C>T; p.R876W; 10:71298044-71298044	large_intestine; rectum	NS	Substitution - Missense
c.2790G>A; p.M930I; 10:71299229-71299229	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.238A>G; p.K80E; 10:71279979-71279979	skin	malignant_melanoma	Substitution - Missense
c.2790G>A; p.M930I; 10:71299229-71299229	skin	malignant_melanoma	Substitution - Missense
c.917C>T; p.T306M; 10:71288583-71288583	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1827C>G; p.P609P; 10:71293459-71293459	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1827C>G; p.P609P; 10:71293459-71293459	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.2772G>A; p.A924A; 10:71299211-71299211	liver	carcinoma	Substitution - coding silent
c.1733A>G; p.Y578C; 10:71292515-71292515	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2460G>C; p.Q820H; 10:71296712-71296712	thyroid	other; neoplasm	Substitution - Missense
c.1572G>A; p.L524L; 10:71291709-71291709	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2586C>T; p.I862I; 10:71298004-71298004	skin	malignant_melanoma	Substitution - coding silent
c.2020C>T; p.L674L; 10:71293778-71293778	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2263C>T; p.R755C; 10:71295898-71295898	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Missense
c.1051G>T; p.G351W; 10:71288717-71288717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2263C>T; p.R755C; 10:71295898-71295898	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1653C>T; p.C551C; 10:71291790-71291790	skin	malignant_melanoma	Substitution - coding silent
c.776C>T; p.S259F; 10:71287640-71287640	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.873G>A; p.Q291Q; 10:71287737-71287737	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.965G>A; p.R322H; 10:71288631-71288631	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2646G>A; p.M882I; 10:71298064-71298064	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.619G>A; p.D207N; 10:71286755-71286755	skin	malignant_melanoma	Substitution - Missense
c.721G>A; p.V241I; 10:71286857-71286857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1001G>A; p.G334E; 10:71288667-71288667	skin	malignant_melanoma	Substitution - Missense
c.526C>T; p.P176S; 10:71285403-71285403	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1124C>T; p.A375V; 10:71290939-71290939	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2221G>T; p.E741*; 10:71295856-71295856	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1047A>C; p.T349T; 10:71288713-71288713	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1828A>T; p.T610S; 10:71293460-71293460	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.301A>T; p.T101S; 10:71280042-71280042	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1741T>C; p.Y581H; 10:71292523-71292523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1804A>G; p.S602G; 10:71293436-71293436	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.764G>A; p.W255*; 10:71287628-71287628	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.2399G>T; p.S800I; 10:71296651-71296651	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.365G>T; p.G122V; 10:71284780-71284780	prostate	carcinoma	Substitution - Missense
c.2404G>A; p.A802T; 10:71296656-71296656	skin; acral	malignant_melanoma	Substitution - Missense
c.1574G>A; p.R525H; 10:71291711-71291711	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1259G>A; p.G420D; 10:71291074-71291074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1774C>T; p.P592S; 10:71293406-71293406	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.1258G>C; p.G420R; 10:71291073-71291073	breast	carcinoma	Substitution - Missense
c.2474A>T; p.H825L; 10:71296726-71296726	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.860G>A; p.G287D; 10:71287724-71287724	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1540G>A; p.D514N; 10:71291677-71291677	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.358C>A; p.L120I; 10:71284773-71284773	breast	carcinoma	Substitution - Missense
c.1436G>A; p.S479N; 10:71291573-71291573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2553G>T; p.L851L; 10:71297971-71297971	skin	malignant_melanoma	Substitution - coding silent
c.811C>T; p.R271W; 10:71287675-71287675	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.879C>T; p.T293T; 10:71287743-71287743	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.337T>A; p.S113T; 10:71284752-71284752	parathyroid	adenoma	Substitution - Missense
c.414C>T; p.T138T; 10:71284829-71284829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.169G>A; p.A57T; 10:71279910-71279910	breast	carcinoma	Substitution - Missense
c.414C>T; p.T138T; 10:71284829-71284829	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.169G>A; p.A57T; 10:71279910-71279910	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.860G>T; p.G287V; 10:71287724-71287724	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1510G>T; p.G504W; 10:71291647-71291647	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1156G>A; p.V386M; 10:71290971-71290971	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2300G>A; p.R767K; 10:71295935-71295935	thyroid	carcinoma	Substitution - Missense
c.1199G>A; p.R400H; 10:71291014-71291014	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1573C>T; p.R525C; 10:71291710-71291710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.733+1G>T; p.?; 10:71286870-71286870	breast	carcinoma	Unknown
c.428G>T; p.R143L; 10:71284843-71284843	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.647G>A; p.R216H; 10:71286783-71286783	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.86A>C; p.D29A; 10:71279827-71279827	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1270G>A; p.V424I; 10:71291085-71291085	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.647G>A; p.R216H; 10:71286783-71286783	pancreas	carcinoma	Substitution - Missense
c.408G>A; p.A136A; 10:71284823-71284823	thyroid	other; neoplasm	Substitution - coding silent
c.1676C>A; p.P559H; 10:71291813-71291813	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.408G>A; p.A136A; 10:71284823-71284823	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2176G>A; p.E726K; 10:71295811-71295811	skin	malignant_melanoma	Substitution - Missense
c.92G>A; p.G31D; 10:71279833-71279833	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2064C>T; p.S688S; 10:71293822-71293822	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.1258G>A; p.G420S; 10:71291073-71291073	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2487A>G; p.A829A; 10:71296739-71296739	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2217G>T; p.V739V; 10:71295852-71295852	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.862C>T; p.Q288*; 10:71287726-71287726	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.637C>T; p.R213C; 10:71286773-71286773	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1340C>A; p.A447D; 10:71291477-71291477	pancreas	carcinoma	Substitution - Missense
c.1340C>A; p.A447D; 10:71291477-71291477	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.247G>T; p.G83C; 10:71279988-71279988	prostate	adenoma	Substitution - Missense
c.319G>T; p.E107*; 10:71284734-71284734	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2271C>T; p.S757S; 10:71295906-71295906	skin	malignant_melanoma	Substitution - coding silent
c.319G>T; p.E107*; 10:71284734-71284734	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Nonsense
c.506A>T; p.E169V; 10:71285383-71285383	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1612C>T; p.P538S; 10:71291749-71291749	stomach	adenocarcinoma	Substitution - Missense
c.1256G>C; p.G419A; 10:71291071-71291071	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.924G>A; p.W308*; 10:71288590-71288590	skin	malignant_melanoma	Substitution - Nonsense
c.2587C>T; p.R863C; 10:71298005-71298005	skin	malignant_melanoma	Substitution - Missense
c.1674C>G; p.I558M; 10:71291811-71291811	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2414A>G; p.E805G; 10:71296666-71296666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1632C>A; p.S544R; 10:71291769-71291769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2331C>T; p.I777I; 10:71296583-71296583	skin	malignant_melanoma	Substitution - coding silent
c.1347C>T; p.A449A; 10:71291484-71291484	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.856G>A; p.E286K; 10:71287720-71287720	prostate	carcinoma	Substitution - Missense
c.700C>T; p.R234C; 10:71286836-71286836	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2451G>C; p.G817G; 10:71296703-71296703	skin	malignant_melanoma	Substitution - coding silent
c.1269C>A; p.P423P; 10:71291084-71291084	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1022C>T; p.T341M; 10:71288688-71288688	pancreas	carcinoma	Substitution - Missense
c.2405C>G; p.A802G; 10:71296657-71296657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2102C>T; p.A701V; 10:71293860-71293860	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1412C>T; p.S471F; 10:71291549-71291549	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1469C>T; p.T490M; 10:71291606-71291606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.316C>T; p.R106C; 10:71284731-71284731	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.1181T>G; p.V394G; 10:71290996-71290996	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1469C>T; p.T490M; 10:71291606-71291606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.671C>T; p.T224I; 10:71286807-71286807	skin	malignant_melanoma	Substitution - Missense
c.402C>T; p.S134S; 10:71284817-71284817	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.402C>T; p.S134S; 10:71284817-71284817	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1507C>T; p.L503L; 10:71291644-71291644	breast	carcinoma	Substitution - coding silent
c.1113A>G; p.S371S; 10:71290928-71290928	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1302G>A; p.P434P; 10:71291439-71291439	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.567G>T; p.K189N; 10:71286703-71286703	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.413C>T; p.T138I; 10:71284828-71284828	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.404C>T; p.S135F; 10:71284819-71284819	skin	malignant_melanoma	Substitution - Missense
c.2580G>C; p.L860L; 10:71297998-71297998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2792G>A; p.G931D; 10:71299231-71299231	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1130A>G; p.Y377C; 10:71290945-71290945	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2365G>A; p.A789T; 10:71296617-71296617	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1189G>T; p.V397L; 10:71291004-71291004	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1549C>T; p.R517W; 10:71291686-71291686	central_nervous_system; brain	glioma; oligodendroglioma_Grade_III	Substitution - Missense
c.2671C>T; p.R891W; 10:71298089-71298089	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2671C>T; p.R891W; 10:71298089-71298089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.861C>T; p.G287G; 10:71287725-71287725	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1432C>T; p.P478S; 10:71291569-71291569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2808G>T; p.L936L; 10:71299247-71299247	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2063C>G; p.S688C; 10:71293821-71293821	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1526G>T; p.G509V; 10:71291663-71291663	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2659C>T; p.L887F; 10:71298077-71298077	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.2361G>A; p.Q787Q; 10:71296613-71296613	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.690C>T; p.I230I; 10:71286826-71286826	skin	malignant_melanoma	Substitution - coding silent
c.2479A>G; p.T827A; 10:71296731-71296731	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2708C>T; p.T903M; 10:71299147-71299147	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2708C>T; p.T903M; 10:71299147-71299147	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.642G>T; p.Q214H; 10:71286778-71286778	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.912G>A; p.A304A; 10:71288578-71288578	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.530C>T; p.P177L; 10:71285407-71285407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.912G>A; p.A304A; 10:71288578-71288578	breast	carcinoma	Substitution - coding silent
c.1361G>A; p.G454E; 10:71291498-71291498	skin	malignant_melanoma	Substitution - Missense
c.1496G>A; p.G499E; 10:71291633-71291633	skin	malignant_melanoma	Substitution - Missense
c.1285G>A; p.A429T; 10:71291100-71291100	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1494T>C; p.D498D; 10:71291631-71291631	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1361G>A; p.G454E; 10:71291498-71291498	skin	malignant_melanoma	Substitution - Missense
c.715G>A; p.A239T; 10:71286851-71286851	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1285G>A; p.A429T; 10:71291100-71291100	prostate	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]